Compile Data Set for Download or QSAR
Report error Found 140 Enz. Inhib. hit(s) with all data for entry = 50012085
TargetCoagulation factor X(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM12751(CHEMBL152854 | 1-(3-carbamimidoylphenyl)-3-methyl-...)
Affinity DataKi:  0.0130nMAssay Description:Tested for binding affinity against human Coagulation factor Xa (trypsin-like serine protease)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114453(2-(6-Chloro-naphthalen-2-yl)-5-trifluoromethyl-2H-...)
Affinity DataIC50: 4nMAssay Description:Inhibitory activity against coagulation factor XaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114434(2-(3-Fluoro-naphthalen-2-yl)-5-methyl-2H-pyrazole-...)
Affinity DataKi:  5.70nMAssay Description:Tested for inhibitory activity against Coagulation factor Xa (trypsin-like serine protease) of the compoundMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114435(2-(3-Cyano-naphthalen-2-yl)-5-methyl-2H-pyrazole-3...)
Affinity DataIC50: 6nMAssay Description:Inhibitory activity against coagulation factor XaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114434(2-(3-Fluoro-naphthalen-2-yl)-5-methyl-2H-pyrazole-...)
Affinity DataIC50: 9nMAssay Description:Inhibitory activity against coagulation factor XaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114436(2-(6-Chloro-naphthalen-2-yl)-5-methyl-2H-pyrazole-...)
Affinity DataIC50: 11nMAssay Description:Inhibitory activity against coagulation factor XaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM12751(CHEMBL152854 | 1-(3-carbamimidoylphenyl)-3-methyl-...)
Affinity DataKi:  16nMAssay Description:Tested for the binding affinity against trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114439(2-(6-Bromo-naphthalen-2-yl)-5-methyl-2H-pyrazole-3...)
Affinity DataIC50: 18nMAssay Description:Inhibitory activity against coagulation factor XaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114450(2-(3-Carbamimidoyl-naphthalen-2-yl)-5-methyl-2H-py...)
Affinity DataIC50: 21nMAssay Description:Inhibitory activity against coagulation factor XaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114437(2-(3-Carbamoyl-naphthalen-2-yl)-5-methyl-2H-pyrazo...)
Affinity DataIC50: 24nMAssay Description:Inhibitory activity against coagulation factor XaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114443(5-Methyl-2-(3-sulfamoyl-naphthalen-2-yl)-2H-pyrazo...)
Affinity DataIC50: 24nMAssay Description:Inhibitory activity against coagulation factor XaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114451(2-(3-Fluoro-naphthalen-2-yl)-5-trifluoromethyl-2H-...)
Affinity DataIC50: 27nMAssay Description:Inhibitory activity against coagulation factor XaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114444(2-(3-Aminomethyl-naphthalen-2-yl)-5-methyl-2H-pyra...)
Affinity DataIC50: 38nMAssay Description:Inhibitory activity against coagulation factor XaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114433(2-(3-Methanesulfonyl-naphthalen-2-yl)-5-methyl-2H-...)
Affinity DataIC50: 45nMAssay Description:Inhibitory activity against coagulation factor XaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114446(5-Methyl-2-naphthalen-2-yl-2H-pyrazole-3-carboxyli...)
Affinity DataIC50: 104nMAssay Description:Inhibitory activity against coagulation factor XaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114438(2-(3-Bromo-naphthalen-2-yl)-5-methyl-2H-pyrazole-3...)
Affinity DataIC50: 143nMAssay Description:Inhibitory activity against coagulation factor XaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM12751(CHEMBL152854 | 1-(3-carbamimidoylphenyl)-3-methyl-...)
Affinity DataKi:  300nMAssay Description:Tested for the binding affinity against thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114447(3-[3-Methyl-5-(2'-sulfamoyl-biphenyl-4-ylcarbamoyl...)
Affinity DataIC50: 376nMAssay Description:Inhibitory activity against coagulation factor XaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114432(2-(3-Hydroxymethyl-naphthalen-2-yl)-5-methyl-2H-py...)
Affinity DataIC50: 483nMAssay Description:Inhibitory activity against coagulation factor XaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114449(3-[3-Methyl-5-(2'-sulfamoyl-biphenyl-4-ylcarbamoyl...)
Affinity DataIC50: 545nMAssay Description:Inhibitory activity against coagulation factor XaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114452(2-[3-(N,N-Dimethyl-carbamimidoyl)-naphthalen-2-yl]...)
Affinity DataIC50: 1.65E+3nMAssay Description:Inhibitory activity against coagulation factor XaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114441(2-(6-Methoxy-naphthalen-2-yl)-5-methyl-2H-pyrazole...)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibitory activity against coagulation factor XaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114445(2-(6-Hydroxy-naphthalen-2-yl)-5-methyl-2H-pyrazole...)
Affinity DataIC50: 3.51E+3nMAssay Description:Inhibitory activity against coagulation factor XaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114448(2-[3-(4,5-Dihydro-1H-imidazol-2-yl)-naphthalen-2-y...)
Affinity DataIC50: 7.82E+3nMAssay Description:Inhibitory activity against coagulation factor XaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKallikrein-1(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114433(2-(3-Methanesulfonyl-naphthalen-2-yl)-5-methyl-2H-...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibitory activity against kallikreinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114452(2-[3-(N,N-Dimethyl-carbamimidoyl)-naphthalen-2-yl]...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibitory activity against trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlasminogen(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114452(2-[3-(N,N-Dimethyl-carbamimidoyl)-naphthalen-2-yl]...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibitory activity against plasminMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114450(2-(3-Carbamimidoyl-naphthalen-2-yl)-5-methyl-2H-py...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibitory activity against trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlasminogen(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114437(2-(3-Carbamoyl-naphthalen-2-yl)-5-methyl-2H-pyrazo...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibitory activity against plasminMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlasminogen(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114447(3-[3-Methyl-5-(2'-sulfamoyl-biphenyl-4-ylcarbamoyl...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibitory activity against plasminMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114439(2-(6-Bromo-naphthalen-2-yl)-5-methyl-2H-pyrazole-3...)
Affinity DataIC50: 1.10E+4nMAssay Description:Tested for the binding affinity against thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKallikrein-1(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114437(2-(3-Carbamoyl-naphthalen-2-yl)-5-methyl-2H-pyrazo...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibitory activity against kallikreinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKallikrein-1(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114445(2-(6-Hydroxy-naphthalen-2-yl)-5-methyl-2H-pyrazole...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibitory activity against kallikreinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114445(2-(6-Hydroxy-naphthalen-2-yl)-5-methyl-2H-pyrazole...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibitory activity against trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKallikrein-1(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114452(2-[3-(N,N-Dimethyl-carbamimidoyl)-naphthalen-2-yl]...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibitory activity against kallikreinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVitamin K-dependent protein C(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114442(2-(3-Hydroxy-naphthalen-2-yl)-5-methyl-2H-pyrazole...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibitory activity against activated protein CMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKallikrein-1(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114450(2-(3-Carbamimidoyl-naphthalen-2-yl)-5-methyl-2H-py...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibitory activity against kallikreinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114442(2-(3-Hydroxy-naphthalen-2-yl)-5-methyl-2H-pyrazole...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibitory activity against trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlasminogen(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114432(2-(3-Hydroxymethyl-naphthalen-2-yl)-5-methyl-2H-py...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibitory activity against plasminMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlasminogen(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114434(2-(3-Fluoro-naphthalen-2-yl)-5-methyl-2H-pyrazole-...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibitory activity against tissue plasminogen activatorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114437(2-(3-Carbamoyl-naphthalen-2-yl)-5-methyl-2H-pyrazo...)
Affinity DataIC50: 1.10E+4nMAssay Description:Tested for the binding affinity against thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKallikrein-1(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114449(3-[3-Methyl-5-(2'-sulfamoyl-biphenyl-4-ylcarbamoyl...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibitory activity against kallikreinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKallikrein-1(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114448(2-[3-(4,5-Dihydro-1H-imidazol-2-yl)-naphthalen-2-y...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibitory activity against kallikreinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVitamin K-dependent protein C(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114446(5-Methyl-2-naphthalen-2-yl-2H-pyrazole-3-carboxyli...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibitory activity against activated protein CMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKallikrein-1(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114443(5-Methyl-2-(3-sulfamoyl-naphthalen-2-yl)-2H-pyrazo...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibitory activity against kallikreinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlasminogen(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114446(5-Methyl-2-naphthalen-2-yl-2H-pyrazole-3-carboxyli...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibitory activity against plasminMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlasminogen(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114449(3-[3-Methyl-5-(2'-sulfamoyl-biphenyl-4-ylcarbamoyl...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibitory activity against plasminMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114442(2-(3-Hydroxy-naphthalen-2-yl)-5-methyl-2H-pyrazole...)
Affinity DataIC50: 1.10E+4nMAssay Description:Tested for the binding affinity against thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlasminogen(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114448(2-[3-(4,5-Dihydro-1H-imidazol-2-yl)-naphthalen-2-y...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibitory activity against plasminMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlasminogen(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114443(5-Methyl-2-(3-sulfamoyl-naphthalen-2-yl)-2H-pyrazo...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibitory activity against plasminMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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