Compile Data Set for Download or QSAR
Report error Found 27 Enz. Inhib. hit(s) with all data for entry = 50012361
TargetEpidermal growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50118009((6,7-Diethoxy-quinazolin-4-yl)-(3-thiazol-2-yl-phe...)
Affinity DataIC50: 2nMAssay Description:Inhibition of (EGFR) epidermal growth factor receptor tyrosine kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50117952((6,7-Diethoxy-quinazolin-4-yl)-(3-furan-2-yl-pheny...)
Affinity DataIC50: 3nMAssay Description:Inhibition of (EGFR) epidermal growth factor receptor tyrosine kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50095256((6,7-Dimethoxy-quinazolin-4-yl)-(3-ethynyl-4-fluor...)
Affinity DataIC50: 4nMAssay Description:Inhibition of (EGFR) epidermal growth factor receptor tyrosine kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50117983((6,7-Diethoxy-quinazolin-4-yl)-(3-thiazol-5-yl-phe...)
Affinity DataIC50: 11nMAssay Description:Inhibition of (EGFR) epidermal growth factor receptor tyrosine kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50117986((6,7-Diethoxy-quinazolin-4-yl)-[3-(1H-pyrazol-3-yl...)
Affinity DataIC50: 11nMAssay Description:Inhibition of (EGFR) epidermal growth factor receptor tyrosine kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50117970((6,7-Diethoxy-quinazolin-4-yl)-(3-thiazol-4-yl-phe...)
Affinity DataIC50: 18nMAssay Description:Inhibition of (EGFR) epidermal growth factor receptor tyrosine kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetFructose-1,6-bisphosphatase 1(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50117957({4-[3-(6,7-Diethoxy-quinazolin-4-ylamino)-phenyl]-...)
Affinity DataIC50: 340nMAssay Description:Concentration required for 50% Inhibition against (F16BP) Fructose-1,6-bisphosphatase in rat double mutant (Gln50Lys Gln55His) enzyme using malachite...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50117961((6,7-Diethoxy-quinazolin-4-yl)-[3-(1H-[1,2,4]triaz...)
Affinity DataIC50: 390nMAssay Description:Inhibition of (EGFR) epidermal growth factor receptor tyrosine kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetFructose-1,6-bisphosphatase 1(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50117955(4-[3-(6,7-Diethoxy-quinazolin-4-ylamino)-phenyl]-t...)
Affinity DataIC50: 520nMAssay Description:Concentration required for 50% Inhibition against (F16BP) Fructose-1,6-bisphosphatase in rat double mutant (Gln50Lys Gln55His) enzyme using malachite...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50118010([3-(2-Amino-thiazol-4-yl)-phenyl]-(6,7-diethoxy-qu...)
Affinity DataIC50: 560nMAssay Description:Inhibition of (EGFR) epidermal growth factor receptor tyrosine kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50117985((6,7-Diethoxy-quinazolin-4-yl)-(3-oxazol-4-yl-phen...)
Affinity DataIC50: 720nMAssay Description:Inhibition of (EGFR) epidermal growth factor receptor tyrosine kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetFructose-1,6-bisphosphatase 1(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50117947((6,7-Diethoxy-quinazolin-4-yl)-[3-(2-methyl-thiazo...)
Affinity DataIC50: 790nMAssay Description:Concentration required for 50% Inhibition against (F16BP) Fructose-1,6-bisphosphatase in rat double mutant (Gln50Lys Gln55His) enzyme using malachite...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50117992((6,7-Diethoxy-quinazolin-4-yl)-(3-pyrimidin-5-yl-p...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of (EGFR) epidermal growth factor receptor tyrosine kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetFructose-1,6-bisphosphatase 1(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50117957({4-[3-(6,7-Diethoxy-quinazolin-4-ylamino)-phenyl]-...)
Affinity DataIC50: 2.90E+3nMAssay Description:Concentration required for 50% Inhibition against (F16BP) Fructose-1,6-bisphosphatase in rat single mutant (Gln55His) enzyme using malachite green as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetFructose-1,6-bisphosphatase 1(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50117955(4-[3-(6,7-Diethoxy-quinazolin-4-ylamino)-phenyl]-t...)
Affinity DataIC50: 3.00E+3nMAssay Description:Concentration required for 50% Inhibition against (F16BP) Fructose-1,6-bisphosphatase in rat single mutant (Gln55His) enzyme using malachite green as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetFructose-1,6-bisphosphatase 1(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50117947((6,7-Diethoxy-quinazolin-4-yl)-[3-(2-methyl-thiazo...)
Affinity DataIC50: 3.80E+3nMAssay Description:Concentration required for 50% Inhibition against (F16BP) Fructose-1,6-bisphosphatase in rat single mutant(Gln55His) enzyme using malachite green ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50117947((6,7-Diethoxy-quinazolin-4-yl)-[3-(2-methyl-thiazo...)
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of Epidermal growth factor receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50117960((6,7-Diethoxy-2-methyl-quinazolin-4-yl)-[3-(2-meth...)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of (EGFR) epidermal growth factor receptor tyrosine kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50117940((6,7-Diethoxy-2-ethyl-quinazolin-4-yl)-[3-(2-methy...)
Affinity DataIC50: 9.30E+3nMAssay Description:Inhibition of (EGFR) epidermal growth factor receptor tyrosine kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetFructose-1,6-bisphosphatase 1(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50117989(4-[3-(2-Dimethylaminomethyl-6,7-diethoxy-quinazoli...)
Affinity DataIC50: 9.50E+3nMAssay Description:Concentration required for 50% Inhibition against recombinant wild type pig enzyme (F16BP) Fructose-1,6-bisphosphataseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50117984((6,7-Diethoxy-quinazolin-4-yl)-[3-(2-methyl-oxazol...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of (EGFR) epidermal growth factor receptor tyrosine kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetFructose-1,6-bisphosphatase 1(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50117947((6,7-Diethoxy-quinazolin-4-yl)-[3-(2-methyl-thiazo...)
Affinity DataIC50: 1.00E+4nMAssay Description:Concentration required for 50% Inhibition against (F16BP) Fructose-1,6-bisphosphatase in rat wild type enzyme using malachite green assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetFructose-1,6-bisphosphatase 1(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50117957({4-[3-(6,7-Diethoxy-quinazolin-4-ylamino)-phenyl]-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Concentration required for 50% Inhibition against (F16BP) Fructose-1,6-bisphosphatase in rat wild type enzyme using malachite green assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetFructose-1,6-bisphosphatase 1(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50117947((6,7-Diethoxy-quinazolin-4-yl)-[3-(2-methyl-thiazo...)
Affinity DataIC50: 1.00E+4nMAssay Description:Concentration required for 50% Inhibition against (F16BP) Fructose-1,6-bisphosphatase in rat single mutant (Gln50Lys) enzyme using malachite green as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetFructose-1,6-bisphosphatase 1(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50117957({4-[3-(6,7-Diethoxy-quinazolin-4-ylamino)-phenyl]-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Concentration required for 50% Inhibition against (F16BP) Fructose-1,6-bisphosphatase in rat single mutant (Gln50Lys) enzyme using malachite green as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetFructose-1,6-bisphosphatase 1(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50117955(4-[3-(6,7-Diethoxy-quinazolin-4-ylamino)-phenyl]-t...)
Affinity DataIC50: 1.00E+4nMAssay Description:Concentration required for 50% Inhibition against (F16BP) Fructose-1,6-bisphosphatase in rat wild type enzyme using malachite green assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetFructose-1,6-bisphosphatase 1(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50117955(4-[3-(6,7-Diethoxy-quinazolin-4-ylamino)-phenyl]-t...)
Affinity DataIC50: 1.00E+4nMAssay Description:Concentration required for 50% Inhibition against (F16BP) Fructose-1,6-bisphosphatase in rat single mutant (Gln50Lys) enzyme using malachite green as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed