Compile Data Set for Download or QSAR
Report error Found 94 Enz. Inhib. hit(s) with all data for entry = 747
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5666(N-(2,6-Difluorophenyl)-N-[5-[[[5-tert-butyl-2-oxaz...)
Affinity DataIC50: 2nMAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5708(N-(5-{[(2-tert-butyl-1,3-oxazol-5-yl)methyl]sulfan...)
Affinity DataIC50: 3nMAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5667(3-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfan...)
Affinity DataIC50: 3nMAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5668(N-[5-[[[5-tert-Butyl-2-oxazolyl]methyl]thio]-2-thi...)
Affinity DataIC50: 3nMAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5661(N-[5-[[[5-(Cyclohexylmethyl)-2-oxazolyl]methyl]thi...)
Affinity DataIC50: 4nMAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5669(N-[5-[[(5-Ethyl-2-oxazolyl)methyl]thio]-2-thiazoly...)
Affinity DataIC50: 5nMAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5670(N-[5-[[(5-Ethyl-2-oxazolyl)methyl]thio]-2-thiazoly...)
Affinity DataIC50: 5nMAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5660(N-[5-[[(5-tert-Butyl-2-oxazolyl)methyl]thio]-2-thi...)
Affinity DataIC50: 5nMAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5662(N-[5-[[[5-tert-Butyl-2-oxazolyl]methyl]thio]-2-thi...)
Affinity DataIC50: 5nMAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5684((2R)-N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]s...)
Affinity DataIC50: 6nMAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5659(N-[5-[[[5-Isopropyl-2-oxazolyl]methyl]thio]-2-thia...)
Affinity DataIC50: 6nMAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5666(N-(2,6-Difluorophenyl)-N-[5-[[[5-tert-butyl-2-oxaz...)
Affinity DataIC50: 10nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5665(N-[5-[[[5-tert-Butyl-2-oxazolyl]methyl]thio]-2-thi...)
Affinity DataIC50: 11nMAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5663(N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfan...)
Affinity DataIC50: 17nMAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5664(propan-2-yl N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)m...)
Affinity DataIC50: 18nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5665(N-[5-[[[5-tert-Butyl-2-oxazolyl]methyl]thio]-2-thi...)
Affinity DataIC50: 19nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5658(N-[5-[[(5-Ethyl-2-oxazolyl)methyl]thio]-2-thiazoly...)
Affinity DataIC50: 20nMAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5664(propan-2-yl N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)m...)
Affinity DataIC50: 25nMAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5683(2-amino-5-thio-substituted thiazole 31 | N-[5-[[[5...)
Affinity DataIC50: 26nMAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5668(N-[5-[[[5-tert-Butyl-2-oxazolyl]methyl]thio]-2-thi...)
Affinity DataIC50: 30nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5662(N-[5-[[[5-tert-Butyl-2-oxazolyl]methyl]thio]-2-thi...)
Affinity DataIC50: 30nMAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5655(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)
Affinity DataIC50: 30nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5661(N-[5-[[[5-(Cyclohexylmethyl)-2-oxazolyl]methyl]thi...)
Affinity DataIC50: 30nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5662(N-[5-[[[5-tert-Butyl-2-oxazolyl]methyl]thio]-2-thi...)
Affinity DataIC50: 30nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5667(3-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfan...)
Affinity DataIC50: 30nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5660(N-[5-[[(5-tert-Butyl-2-oxazolyl)methyl]thio]-2-thi...)
Affinity DataIC50: 40nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5656(tert-butyl 2-[(2-acetamido-1,3-thiazol-5-yl)sulfan...)
Affinity DataIC50: 50nMAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5689(1-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfan...)
Affinity DataIC50: 50nMAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5669(N-[5-[[(5-Ethyl-2-oxazolyl)methyl]thio]-2-thiazoly...)
Affinity DataIC50: 60nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5685((2S)-N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]s...)
Affinity DataIC50: 60nMAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5659(N-[5-[[[5-Isopropyl-2-oxazolyl]methyl]thio]-2-thia...)
Affinity DataIC50: 60nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5670(N-[5-[[(5-Ethyl-2-oxazolyl)methyl]thio]-2-thiazoly...)
Affinity DataIC50: 80nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5681(N-[5-[[(5-Methyl-2-oxazolyl)methyl]thio]-2-thiazol...)
Affinity DataIC50: 90nMAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5663(N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfan...)
Affinity DataIC50: 90nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5668(N-[5-[[[5-tert-Butyl-2-oxazolyl]methyl]thio]-2-thi...)
Affinity DataIC50: 100nMAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5671(N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methane]sulfi...)
Affinity DataIC50: 140nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5671(N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methane]sulfi...)
Affinity DataIC50: 140nMAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5686(benzyl N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl...)
Affinity DataIC50: 150nMAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5654(ethyl 2-[(2-acetamido-1,3-thiazol-5-yl)sulfanyl]ac...)
Affinity DataIC50: 170nMAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5679(N-[5-[[(4-Ethyl-2-oxazolyl)methyl]thio]-2-thiazoly...)
Affinity DataIC50: 200nMAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5672(N-[5-[[(5-tert-Butyl-2-oxazolyl)methyl]sulfonyl]-2...)
Affinity DataIC50: 250nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5672(N-[5-[[(5-tert-Butyl-2-oxazolyl)methyl]sulfonyl]-2...)
Affinity DataIC50: 250nMAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5658(N-[5-[[(5-Ethyl-2-oxazolyl)methyl]thio]-2-thiazoly...)
Affinity DataIC50: 300nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5657(benzyl 2-[(2-acetamido-1,3-thiazol-5-yl)sulfanyl]a...)
Affinity DataIC50: 340nMAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5682(N-[5-[[[5-Phenyl-2-oxazolyl]methyl]thio]-2-thiazol...)
Affinity DataIC50: 350nMAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5680(N-(5-{[(4,5-dimethyl-1,3-oxazol-2-yl)methyl]sulfan...)
Affinity DataIC50: 360nMAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5666(N-(2,6-Difluorophenyl)-N-[5-[[[5-tert-butyl-2-oxaz...)
Affinity DataIC50: 390nMAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5656(tert-butyl 2-[(2-acetamido-1,3-thiazol-5-yl)sulfan...)
Affinity DataIC50: 440nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5661(N-[5-[[[5-(Cyclohexylmethyl)-2-oxazolyl]methyl]thi...)
Affinity DataIC50: 640nMAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5694(N-{5-[(pyridin-3-ylmethyl)sulfanyl]-1,3-thiazol-2-...)
Affinity DataIC50: 680nMAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed
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