Compile Data Set for Download or QSAR
Report error Found 38 Enz. Inhib. hit(s) with all data for entry = 50037090
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18268(5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...)
Affinity DataIC50: 5.10nMAssay Description:Inhibitory activity against Toxoplasma gondii (tg) Dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Escherichia coli)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18050(MTX | cid_126941 | Methotrexate | 2-[(4-{[(2,4-dia...)
Affinity DataIC50: 6nMAssay Description:Inhibitory activity against Escherichia coli (ec) Dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Escherichia coli)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18268(5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...)
Affinity DataIC50: 7nMAssay Description:Inhibitory activity against Escherichia coli (ec) Dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18268(5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...)
Affinity DataIC50: 10nMAssay Description:Inhibitory activity against pneumocystis carinii Dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18268(5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...)
Affinity DataIC50: 18nMAssay Description:Inhibitory activity against recombinant human Dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Escherichia coli)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18069(CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...)
Affinity DataIC50: 20nMAssay Description:Inhibitory activity against Escherichia coli (ec) Dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18050(MTX | cid_126941 | Methotrexate | 2-[(4-{[(2,4-dia...)
Affinity DataIC50: 22nMAssay Description:Inhibitory activity against recombinant human Dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Escherichia coli)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50120979(2-[4-(2,4-Diamino-7,8-dihydro-5H-1,3,6,9-tetraaza-...)
Affinity DataIC50: 900nMAssay Description:Inhibitory activity against Escherichia coli (ec) Dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50120979(2-[4-(2,4-Diamino-7,8-dihydro-5H-1,3,6,9-tetraaza-...)
Affinity DataIC50: 900nMAssay Description:Inhibitory activity against Toxoplasma gondii (tg) Dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50120975(6-(2,4-Dichloro-benzyl)-5,6,7,8-tetrahydro-1,3,6,9...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibitory activity against recombinant human Dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50120974(6-Benzyl-5,6,7,8-tetrahydro-1,3,6,9-tetraaza-anthr...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibitory activity against Toxoplasma gondii (tg) Dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50120979(2-[4-(2,4-Diamino-7,8-dihydro-5H-1,3,6,9-tetraaza-...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibitory activity against pneumocystis carinii Dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50120975(6-(2,4-Dichloro-benzyl)-5,6,7,8-tetrahydro-1,3,6,9...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibitory activity against Toxoplasma gondii (tg) Dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50120976(6-(3,5-Dimethoxy-benzyl)-5,6,7,8-tetrahydro-1,3,6,...)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibitory activity against Toxoplasma gondii (tg) Dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50120977(6-(4-Methoxy-benzyl)-5,6,7,8-tetrahydro-1,3,6,9-te...)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibitory activity against Toxoplasma gondii (tg) Dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Escherichia coli)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50120976(6-(3,5-Dimethoxy-benzyl)-5,6,7,8-tetrahydro-1,3,6,...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibitory activity against Escherichia coli (ec) Dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Escherichia coli)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50120973(2,4-Diamino-7,8-dihydro-5H-1,3,6,9-tetraaza-anthra...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibitory activity against Escherichia coli (ec) Dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Escherichia coli)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50120975(6-(2,4-Dichloro-benzyl)-5,6,7,8-tetrahydro-1,3,6,9...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibitory activity against Escherichia coli (ec) Dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Escherichia coli)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50120978(6-(3,4-Dichloro-benzyl)-5,6,7,8-tetrahydro-1,3,6,9...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibitory activity against Escherichia coli (ec) Dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18069(CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibitory activity against Toxoplasma gondii (tg) Dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50120975(6-(2,4-Dichloro-benzyl)-5,6,7,8-tetrahydro-1,3,6,9...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibitory activity against pneumocystis carinii Dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50120978(6-(3,4-Dichloro-benzyl)-5,6,7,8-tetrahydro-1,3,6,9...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibitory activity against pneumocystis carinii Dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50120978(6-(3,4-Dichloro-benzyl)-5,6,7,8-tetrahydro-1,3,6,9...)
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibitory activity against Toxoplasma gondii (tg) Dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50120979(2-[4-(2,4-Diamino-7,8-dihydro-5H-1,3,6,9-tetraaza-...)
Affinity DataIC50: 5.40E+3nMAssay Description:Inhibitory activity against recombinant human Dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Escherichia coli)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50120977(6-(4-Methoxy-benzyl)-5,6,7,8-tetrahydro-1,3,6,9-te...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibitory activity against Escherichia coli (ec) Dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Escherichia coli)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50120974(6-Benzyl-5,6,7,8-tetrahydro-1,3,6,9-tetraaza-anthr...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibitory activity against Escherichia coli (ec) Dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50120976(6-(3,5-Dimethoxy-benzyl)-5,6,7,8-tetrahydro-1,3,6,...)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibitory activity against pneumocystis carinii Dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50120973(2,4-Diamino-7,8-dihydro-5H-1,3,6,9-tetraaza-anthra...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibitory activity against pneumocystis carinii Dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18069(CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibitory activity against pneumocystis carinii Dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50120977(6-(4-Methoxy-benzyl)-5,6,7,8-tetrahydro-1,3,6,9-te...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibitory activity against pneumocystis carinii Dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50120974(6-Benzyl-5,6,7,8-tetrahydro-1,3,6,9-tetraaza-anthr...)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibitory activity against pneumocystis carinii Dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50120976(6-(3,5-Dimethoxy-benzyl)-5,6,7,8-tetrahydro-1,3,6,...)
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibitory activity against recombinant human Dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50120973(2,4-Diamino-7,8-dihydro-5H-1,3,6,9-tetraaza-anthra...)
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibitory activity against Toxoplasma gondii (tg) Dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50120978(6-(3,4-Dichloro-benzyl)-5,6,7,8-tetrahydro-1,3,6,9...)
Affinity DataIC50: 2.60E+4nMAssay Description:Inhibitory activity against recombinant human Dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50120977(6-(4-Methoxy-benzyl)-5,6,7,8-tetrahydro-1,3,6,9-te...)
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibitory activity against recombinant human Dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50120973(2,4-Diamino-7,8-dihydro-5H-1,3,6,9-tetraaza-anthra...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibitory activity against recombinant human Dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50120974(6-Benzyl-5,6,7,8-tetrahydro-1,3,6,9-tetraaza-anthr...)
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibitory activity against recombinant human Dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18069(CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...)
Affinity DataIC50: 3.40E+5nMAssay Description:Inhibitory activity against recombinant human Dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)