Compile Data Set for Download or QSAR
Report error Found 41 Enz. Inhib. hit(s) with all data for entry = 50037099
TargetATP-dependent translocase ABCB1(Human)
Bulgarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50012278(VINBLASTINE SULFATE | (2ALPHA,2''BETA,3BETA,4ALPHA...)
Affinity DataKi:  100nMAssay Description:High affinity constant at binding site of human P-Glycoprotein (P-gp) in two-affinity modelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Bulgarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50121978(2-(6-Amino-3-imino-3H-xanthen-9-yl)-benzoic acid m...)
Affinity DataKi:  100nMAssay Description:High affinity constant at binding site of human P-Glycoprotein (P-gp) in two-affinity modelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Bulgarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50017712(Apoplon | 3,4,5-trimethoxybenzoyl methyl reserpate...)
Affinity DataKi:  100nMAssay Description:Concentration giving half of the maximal ATPase activity calculated for the high-affinity binding site of the CHO P-Glycoprotein (P-gp) in two-affini...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Bulgarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM20607((2-{4-[(1Z)-1,2-diphenylbut-1-en-1-yl]phenoxy}ethy...)
Affinity DataKi:  100nMAssay Description:Concentration giving half of the maximal ATPase activity calculated for the high-affinity binding site of the CHO P-Glycoprotein (P-gp) in two-affini...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Bulgarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  200nMAssay Description:High affinity constant at binding site of human P-Glycoprotein (P-gp) in two-affinity modelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Bulgarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50005628(verapamil-S | 2-(3,4-Dimethoxy-phenyl)-5-{[2-(3,4-...)
Affinity DataKi:  300nMAssay Description:High affinity constant at binding site of human P-Glycoprotein (P-gp) in two-affinity modelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Bulgarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50121978(2-(6-Amino-3-imino-3H-xanthen-9-yl)-benzoic acid m...)
Affinity DataIC50: 500nMAssay Description:Concentration required for 50% inhibition at binding site of human P-Glycoprotein (P-gp) in one-affinity modelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Bulgarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50001888([3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-...)
Affinity DataKi:  600nMAssay Description:High affinity constant at binding site of human P-Glycoprotein (P-gp) in two-affinity modelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Bulgarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM31768(Nizoral | CHEMBL295698 | Panfungol | Ketoconazole)
Affinity DataKi:  1.20E+3nMAssay Description:High affinity constant at binding site of human P-Glycoprotein (P-gp) in two-affinity modelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Bulgarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50012278(VINBLASTINE SULFATE | (2ALPHA,2''BETA,3BETA,4ALPHA...)
Affinity DataKi:  1.30E+3nMAssay Description:Concentration giving half of the maximal ATPase activity calculated for the high-affinity binding site of the CHO P-Glycoprotein (P-gp) in two-affini...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Bulgarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50005628(verapamil-S | 2-(3,4-Dimethoxy-phenyl)-5-{[2-(3,4-...)
Affinity DataIC50: 1.48E+3nMAssay Description:Concentration required for 50% inhibition at binding site of human P-Glycoprotein (P-gp) in one-affinity modelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Bulgarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50338982((R)-5-((3,4-dimethoxyphenethyl)(methyl)amino)-2-(3...)
Affinity DataKi:  1.60E+3nMAssay Description:Concentration giving half of the maximal ATPase activity calculated for the high-affinity binding site of the CHO P-Glycoprotein (P-gp) in two-affini...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Bulgarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50005628(verapamil-S | 2-(3,4-Dimethoxy-phenyl)-5-{[2-(3,4-...)
Affinity DataIC50: 2.09E+3nMAssay Description:Concentration required for 50% inhibition at binding site of human P-Glycoprotein (P-gp) in one-affinity modelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Bulgarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50005628(verapamil-S | 2-(3,4-Dimethoxy-phenyl)-5-{[2-(3,4-...)
Affinity DataIC50: 2.11E+3nMAssay Description:Concentration required for 50% inhibition (racemic) at binding site of human P-Glycoprotein (P-gp) in one-affinity modelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Bulgarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50338982((R)-5-((3,4-dimethoxyphenethyl)(methyl)amino)-2-(3...)
Affinity DataIC50: 2.37E+3nMAssay Description:Concentration required for 50% inhibition at binding site of human P-Glycoprotein (P-gp) in one-affinity modelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Bulgarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50005628(verapamil-S | 2-(3,4-Dimethoxy-phenyl)-5-{[2-(3,4-...)
Affinity DataKi:  2.50E+3nMAssay Description:Concentration giving half of the maximal ATPase activity calculated for the high-affinity binding site of the CHO P-Glycoprotein (P-gp) in two-affini...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Bulgarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50121975((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...)
Affinity DataKi:  2.60E+3nMAssay Description:High affinity constant at binding site of human P-Glycoprotein (P-gp) in two-affinity modelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Bulgarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM18957((2-{4-[(2-butyl-1-benzofuran-3-yl)carbonyl]-2,6-di...)
Affinity DataKi:  3.20E+3nMAssay Description:Concentration giving half of the maximal ATPase activity calculated for the high-affinity binding site of the CHO P-Glycoprotein (P-gp) in two-affini...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Bulgarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50067133(CHEMBL631 | 1-[2-(2-Hydroxy-3-propylamino-propoxy)...)
Affinity DataKi:  4.20E+3nMAssay Description:Concentration giving half of the maximal ATPase activity calculated for the high-affinity binding site of the CHO P-Glycoprotein (P-gp) in two-affini...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Bulgarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50121977(Norverapamil (6%) | 2-(3,4-Dimethoxy-phenyl)-5-[2-...)
Affinity DataIC50: 4.24E+3nMAssay Description:Concentration required for 50% inhibition at binding site of human P-Glycoprotein (P-gp) in one-affinity modelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Bulgarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50121975((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...)
Affinity DataKi:  5.00E+3nMAssay Description:Concentration giving half of the maximal ATPase activity calculated for the high-affinity binding site of the CHO P-Glycoprotein (P-gp) in two-affini...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Bulgarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataIC50: 5.30E+3nMAssay Description:Concentration required for 50% inhibition at binding site of human P-Glycoprotein (P-gp) in one-affinity modelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Bulgarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50121973(CHEMBL152371 | 1-{2-[4-(2-Hydroxy-3-isopropylamino...)
Affinity DataKi:  5.50E+3nMAssay Description:High affinity constant at binding site of human P-Glycoprotein (P-gp) in two-affinity modelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Bulgarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM79181(cid_2913535 | TRIFLUOPERAZINE | SMR000059133 | MLS...)
Affinity DataKi:  6.50E+3nMAssay Description:Concentration giving half of the maximal ATPase activity calculated for the high-affinity binding site of the CHO P-Glycoprotein (P-gp) in two-affini...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Bulgarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50367247(Quinamm | Quinsan | QUININE | cid_3034034)
Affinity DataKi:  1.20E+4nMAssay Description:High affinity constant at binding site of human P-Glycoprotein (P-gp) in two-affinity modelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Bulgarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50001888([3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-...)
Affinity DataKi:  1.22E+4nMAssay Description:Concentration giving half of the maximal ATPase activity calculated for the high-affinity binding site of the CHO P-Glycoprotein (P-gp) in two-affini...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Bulgarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM31768(Nizoral | CHEMBL295698 | Panfungol | Ketoconazole)
Affinity DataIC50: 1.30E+4nMAssay Description:Concentration required for 50% inhibition at binding site of human P-Glycoprotein (P-gp) in one-affinity modelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Bulgarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM67544(TRIFLUPROMAZINE | SR-01000000224-4 | N,N-dimethyl-...)
Affinity DataKi:  1.57E+4nMAssay Description:Concentration giving half of the maximal ATPase activity calculated for the high-affinity binding site of the CHO P-Glycoprotein (P-gp) in two-affini...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Bulgarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50012278(VINBLASTINE SULFATE | (2ALPHA,2''BETA,3BETA,4ALPHA...)
Affinity DataIC50: 3.40E+4nMAssay Description:Concentration required for 50% inhibition at binding site of human P-Glycoprotein (P-gp) in one-affinity modelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Bulgarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM25761(Propanolol,(+/-) | PROPRANOLOL, l- | PROPRANOLOL,(...)
Affinity DataKi:  4.80E+4nMAssay Description:High affinity constant at binding site of human P-Glycoprotein (P-gp) in two-affinity modelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Bulgarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50241343(H-168/68 | 5-methoxy-2-(2-(4-methoxy-3,5-dimethylp...)
Affinity DataIC50: 8.90E+4nMAssay Description:Concentration required for 50% inhibition at binding site of human P-Glycoprotein (P-gp) in one-affinity modelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Bulgarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50241343(H-168/68 | 5-methoxy-2-(2-(4-methoxy-3,5-dimethylp...)
Affinity DataIC50: 9.12E+4nMAssay Description:Concentration required for 50% inhibition at binding site of human P-Glycoprotein (P-gp) in one-affinity modelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Bulgarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50241343(H-168/68 | 5-methoxy-2-(2-(4-methoxy-3,5-dimethylp...)
Affinity DataIC50: 9.72E+4nMAssay Description:Concentration required for 50% inhibition at binding site of human P-Glycoprotein (P-gp) in one-affinity modelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Bulgarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50246936(S-(-)-propanolol | (-)-(S)-Propranolol | [2-Hydrox...)
Affinity DataKi:  1.70E+5nMAssay Description:Concentration giving half of the maximal ATPase activity calculated for the high-affinity binding site of the CHO P-Glycoprotein (P-gp) in two-affini...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Bulgarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM25756(Betalok | Spesikor | {2-hydroxy-3-[4-(2-methoxyeth...)
Affinity DataKi:  2.00E+5nMAssay Description:High affinity constant at binding site of human P-Glycoprotein (P-gp) in two-affinity modelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Bulgarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50121975((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...)
Affinity DataIC50: 3.40E+5nMAssay Description:Concentration required for 50% inhibition at binding site of human P-Glycoprotein (P-gp) in one-affinity modelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Bulgarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50367247(Quinamm | Quinsan | QUININE | cid_3034034)
Affinity DataIC50: 4.30E+5nMAssay Description:Concentration required for 50% inhibition at binding site of human P-Glycoprotein (P-gp) in one-affinity modelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Bulgarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM25761(Propanolol,(+/-) | PROPRANOLOL, l- | PROPRANOLOL,(...)
Affinity DataIC50: 5.73E+5nMAssay Description:Concentration required for 50% inhibition at binding site of human P-Glycoprotein (P-gp) in one-affinity modelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Bulgarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50246936(S-(-)-propanolol | (-)-(S)-Propranolol | [2-Hydrox...)
Affinity DataIC50: 5.74E+5nMAssay Description:Concentration required for 50% inhibition at binding site of human P-Glycoprotein (P-gp) in one-affinity modelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Bulgarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM36108((R)-propranolol)
Affinity DataIC50: 5.83E+5nMAssay Description:Concentration required for 50% inhibition at binding site of human P-Glycoprotein (P-gp) in one-affinity modelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Bulgarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM25756(Betalok | Spesikor | {2-hydroxy-3-[4-(2-methoxyeth...)
Affinity DataIC50: 1.30E+6nMAssay Description:Concentration required for 50% inhibition at binding site of human P-Glycoprotein (P-gp) in one-affinity modelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed