Compile Data Set for Download or QSAR
Report error Found 13 Enz. Inhib. hit(s) with all data for entry = 2145
LigandPNGBDBM17327((2S)-2-({1-[benzyl(1,3-thiazol-5-ylmethyl)carbamoy...)
Affinity DataIC50: 0.560nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2007
Entry Details Article
PubMed
LigandPNGBDBM17328((2S)-2-[(1-{[3-cyclohexyl-1-(1,3-thiazol-5-yl)prop...)
Affinity DataIC50: 0.710nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2007
Entry Details Article
PubMed
LigandPNGBDBM17335(1-[(2R)-2-{[(4-cyanophenyl)methyl](methyl)amino}-3...)
Affinity DataIC50: 0.920nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2007
Entry Details Article
PubMed
LigandPNGBDBM17325(CHEMBL29982 | (2S)-2-[(4-{[butyl(2-cyclohexylethyl...)
Affinity DataIC50: 1.10nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2007
Entry Details Article
PubMed
LigandPNGBDBM17333(1-[(2R)-2-{[(4-cyanophenyl)methyl]amino}-3-(1-meth...)
Affinity DataIC50: 1.20nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2007
Entry Details Article
PubMed
LigandPNGBDBM17326((2S)-2-[(1-{2-[benzyl(1,3-thiazol-5-ylmethyl)amino...)
Affinity DataIC50: 2.5nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2007
Entry Details Article
PubMed
LigandPNGBDBM17334(1-[(2S)-2-{[(4-cyanophenyl)methyl]amino}-3-(1-meth...)
Affinity DataIC50: 130nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2007
Entry Details Article
PubMed
LigandPNGBDBM17331(1-[(2R)-3-(4-cyanophenyl)-2-{[(1-methyl-1H-imidazo...)
Affinity DataIC50: 240nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2007
Entry Details Article
PubMed
LigandPNGBDBM17330(1-(2-{benzyl[(1-methyl-1H-imidazol-5-yl)methyl]ami...)
Affinity DataIC50: 280nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2007
Entry Details Article
PubMed
LigandPNGBDBM17332(1-[(2S)-3-(4-cyanophenyl)-2-{[(1-methyl-1H-imidazo...)
Affinity DataIC50: 310nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2007
Entry Details Article
PubMed
LigandPNGBDBM17329(1-(2-{[(4-cyanophenyl)methyl][(1-methyl-1H-imidazo...)
Affinity DataIC50: 560nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2007
Entry Details Article
PubMed
LigandPNGBDBM17335(1-[(2R)-2-{[(4-cyanophenyl)methyl](methyl)amino}-3...)
Affinity DataIC50: 1.60E+3nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting GGTase-1 was determined by measuring the transfer of [3H]-geranylgeranylpyrophosphate to substrate Ha-R...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2007
Entry Details Article
PubMed
LigandPNGBDBM17333(1-[(2R)-2-{[(4-cyanophenyl)methyl]amino}-3-(1-meth...)
Affinity DataIC50: 3.50E+3nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting GGTase-1 was determined by measuring the transfer of [3H]-geranylgeranylpyrophosphate to substrate Ha-R...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2007
Entry Details Article
PubMed