Compile Data Set for Download or QSAR
Report error Found 15 Enz. Inhib. hit(s) with all data for entry = 50013191
TargetGlutamate carboxypeptidase 2(Human)
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM17659(pentanedioic acid analogue, (RS)-1 | 2-(phosphonom...)
Affinity DataKi:  0.200nMAssay Description:In vitro inhibitory activity against glutamate carboxypeptidase II (GCP II) using N-acetyl-L-aspartyl-[3H]L-glutamate as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate carboxypeptidase 2(Human)
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM17659(pentanedioic acid analogue, (RS)-1 | 2-(phosphonom...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of N-acetyl-L-aspartyl-[3H]L-glutamate binding to glutamate carboxypeptidase II (GCP II)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate carboxypeptidase 2(Human)
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50109593(SQ-14603 | 2-Mercaptomethyl-3-phenyl-propionic aci...)
Affinity DataKi:  11nMAssay Description:In vitro inhibitory activity against glutamate carboxypeptidase II (GCP II) using N-acetyl-L-aspartyl-[3H]L-glutamate as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM17755(pentanedioic acid analogue, (RS)-3 | CHEMBL303352 ...)
Affinity DataIC50: 90nMAssay Description:Inhibition of N-acetyl-L-aspartyl-[3H]L-glutamate binding to glutamate carboxypeptidase II (GCP II)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50127617(2-(2-Mercapto-ethyl)-pentanedioic acid | CHEMBL292...)
Affinity DataIC50: 580nMAssay Description:Inhibition of N-acetyl-L-aspartyl-[3H]L-glutamate binding to glutamate carboxypeptidase II (GCP II)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50127612(2-(4-Mercapto-butyl)-pentanedioic acid | CHEMBL603...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of N-acetyl-L-aspartyl-[3H]L-glutamate binding to glutamate carboxypeptidase II (GCP II)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50127615(2-(2-Phosphonooxy-ethyl)-pentanedioic acid | CHEMB...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of N-acetyl-L-aspartyl-[3H]L-glutamate binding to glutamate carboxypeptidase II (GCP II)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50127620(2-Phosphonooxy-pentanedioic acid | CHEMBL302413)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of N-acetyl-L-aspartyl-[3H]L-glutamate binding to glutamate carboxypeptidase II (GCP II)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50127619(5-Mercapto-pentanoic acid | CHEMBL294565)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of N-acetyl-L-aspartyl-[3H]L-glutamate binding to glutamate carboxypeptidase II (GCP II)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50127611(2-Mercapto-pentanedioic acid | CHEMBL304885)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of N-acetyl-L-aspartyl-[3H]L-glutamate binding to glutamate carboxypeptidase II (GCP II)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50127621(2-(5-Mercapto-pentyl)-pentanedioic acid | CHEMBL61...)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of N-acetyl-L-aspartyl-[3H]L-glutamate binding to glutamate carboxypeptidase II (GCP II)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50127618(2-[3-(4,6-Dicarboxy-hexyldisulfanyl)-propyl]-penta...)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of N-acetyl-L-aspartyl-[3H]L-glutamate binding to glutamate carboxypeptidase II (GCP II)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50127614(2-Mercaptomethyl-pentanedioic acid | CHEMBL60941)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of N-acetyl-L-aspartyl-[3H]L-glutamate binding to glutamate carboxypeptidase II (GCP II)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50127616(2-(3-Methylsulfanyl-propyl)-pentanedioic acid | CH...)
Affinity DataIC50: 6.50E+3nMAssay Description:Inhibition of N-acetyl-L-aspartyl-[3H]L-glutamate binding to glutamate carboxypeptidase II (GCP II)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50127613(2-(3-Tritylsulfanyl-propyl)-pentanedioic acid | CH...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-acetyl-L-aspartyl-[3H]L-glutamate binding to glutamate carboxypeptidase II (GCP II)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed