Compile Data Set for Download or QSAR
Report error Found 9 Enz. Inhib. hit(s) with all data for entry = 2794
TargetAcetylcholinesterase(Human)
University of North Carolina at Chapel Hill

LigandPNGBDBM8961(CHEMBL95 | Cognex | cid_1935 | CHEMBL1337960 | 1,2...)
Affinity DataKi:  6.90nM ΔG°:  -46.1kJ/molepH: 7.4 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Estimates of the competitive inhibition constants (Ki) were ob...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2008
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAcetylcholinesterase(Human)
University of North Carolina at Chapel Hill

LigandPNGBDBM24710(6-chloro-2-methoxyacridin-9-amine | 9-Amino-6-Chlo...)
Affinity DataKi:  49nM ΔG°:  -41.3kJ/molepH: 7.4 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Estimates of the competitive inhibition constants (Ki) were ob...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2008
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of North Carolina at Chapel Hill

LigandPNGBDBM24709(CHEMBL94007 | 7-ethoxyacridine-3,9-diamine | 6,9-D...)
Affinity DataKi:  490nM ΔG°:  -35.7kJ/molepH: 7.4 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Estimates of the competitive inhibition constants (Ki) were ob...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2008
Entry Details Article
PubMed
TargetLiver carboxylesterase 1(Human)
University of North Carolina at Chapel Hill

LigandPNGBDBM24710(6-chloro-2-methoxyacridin-9-amine | 9-Amino-6-Chlo...)
Affinity DataKi:  5.80E+3nM ΔG°:  -29.6kJ/molepH: 7.4 T: 2°CAssay Description:Inhibition constants were calculated by assessment of the reduction in the formation of o-nitrophenol, as monitored by a spectrophotometric assay at ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2008
Entry Details Article
PubMed
TargetLiver carboxylesterase 1(Human)
University of North Carolina at Chapel Hill

LigandPNGBDBM24709(CHEMBL94007 | 7-ethoxyacridine-3,9-diamine | 6,9-D...)
Affinity DataKi:  1.71E+4nM ΔG°:  -26.9kJ/molepH: 7.4 T: 2°CAssay Description:Inhibition constants were calculated by assessment of the reduction in the formation of o-nitrophenol, as monitored by a spectrophotometric assay at ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2008
Entry Details Article
PubMed
TargetLiver carboxylesterase 1(Human)
University of North Carolina at Chapel Hill

LigandPNGBDBM8961(CHEMBL95 | Cognex | cid_1935 | CHEMBL1337960 | 1,2...)
Affinity DataKi: >1.00E+5nM ΔG°: >-22.6kJ/molepH: 7.4 T: 2°CAssay Description:Inhibition constants were calculated by assessment of the reduction in the formation of o-nitrophenol, as monitored by a spectrophotometric assay at ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2008
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCoagulation factor XII(Human)
University of North Carolina at Chapel Hill

LigandPNGBDBM8961(CHEMBL95 | Cognex | cid_1935 | CHEMBL1337960 | 1,2...)
Affinity DataKi: >1.00E+5nM ΔG°: >-22.6kJ/molepH: 7.4 T: 2°CAssay Description:Inhibition constants were calculated by assessment of the reduction in the formation of o-nitrophenol, as monitored by a spectrophotometric assay at ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2008
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
University of North Carolina at Chapel Hill

LigandPNGBDBM24709(CHEMBL94007 | 7-ethoxyacridine-3,9-diamine | 6,9-D...)
Affinity DataKi: >1.00E+5nM ΔG°: >-22.6kJ/molepH: 7.4 T: 2°CAssay Description:Inhibition constants were calculated by assessment of the reduction in the formation of o-nitrophenol, as monitored by a spectrophotometric assay at ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2008
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
University of North Carolina at Chapel Hill

LigandPNGBDBM24710(6-chloro-2-methoxyacridin-9-amine | 9-Amino-6-Chlo...)
Affinity DataKi: >1.00E+5nM ΔG°: >-22.6kJ/molepH: 7.4 T: 2°CAssay Description:Inhibition constants were calculated by assessment of the reduction in the formation of o-nitrophenol, as monitored by a spectrophotometric assay at ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2008
Entry Details Article
PubMed