Compile Data Set for Download or QSAR
Report error Found 75 Enz. Inhib. hit(s) with all data for entry = 50035307
TargetNeutrophil collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129986(2-(((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-...)
Affinity DataIC50: 0.560nMAssay Description:Inhibition of matrix metalloprotease-8More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50090259((4-Benzyl-benzyl)-[2-((S)-2,2-dimethyl-1-methylcar...)
Affinity DataIC50: 0.770nMAssay Description:Inhibition of matrix metalloprotease-8More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129986(2-(((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of matrix metalloprotease-12More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129994(2-(((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-...)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of matrix metalloprotease-8More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129987(2-(((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-...)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of matrix metalloprotease-8More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129986(2-(((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-...)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of matrix metalloprotease-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM8465(CGS 27023 | CHEMBL514138 | hydroxamate analogue 1 ...)
Affinity DataIC50: 3nMAssay Description:Inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129994(2-(((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-...)
Affinity DataIC50: 4nMAssay Description:Inhibition of matrix metalloprotease-12More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129990((4-Benzyl-benzyl)-[2-((S)-2,2-dimethyl-1-methylcar...)
Affinity DataIC50: 4.30nMAssay Description:Inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129987(2-(((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-...)
Affinity DataIC50: 4.5nMAssay Description:Inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129987(2-(((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-...)
Affinity DataIC50: 5nMAssay Description:Inhibition of matrix metalloprotease-12More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129987(2-(((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-...)
Affinity DataIC50: 6.60nMAssay Description:Inhibition of matrix metalloprotease-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129994(2-(((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-...)
Affinity DataIC50: 6.60nMAssay Description:Inhibition of matrix metalloprotease-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129994(2-(((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-...)
Affinity DataIC50: 7nMAssay Description:Inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50130006((4-Benzyl-benzyl)-[2-((S)-2,2-dimethyl-1-methylcar...)
Affinity DataIC50: 7.70nMAssay Description:Inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129998((4-Benzyl-benzyl)-[2-((S)-2,2-dimethyl-1-methylcar...)
Affinity DataIC50: 7.70nMAssay Description:Inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50090259((4-Benzyl-benzyl)-[2-((S)-2,2-dimethyl-1-methylcar...)
Affinity DataIC50: 8.20nMAssay Description:Inhibition of matrix metalloprotease-12More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129986(2-(((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-...)
Affinity DataIC50: 8.30nMAssay Description:Inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50130007((4-Benzyl-benzyl)-[4-(4-bromo-phenyl)-2-((S)-2,2-d...)
Affinity DataIC50: 9.40nMAssay Description:Inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129999((4-Benzyl-benzyl)-[2-((S)-2,2-dimethyl-1-methylcar...)
Affinity DataIC50: 10nMAssay Description:Inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50090259((4-Benzyl-benzyl)-[2-((S)-2,2-dimethyl-1-methylcar...)
Affinity DataIC50: 10nMAssay Description:Inhibition of matrix metalloprotease-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129991([2-((S)-2,2-Dimethyl-1-methylcarbamoyl-propylcarba...)
Affinity DataIC50: 11nMAssay Description:Inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129993(Benzyl-[2-((S)-2,2-dimethyl-1-methylcarbamoyl-prop...)
Affinity DataIC50: 12nMAssay Description:Inhibition of matrix metalloprotease-8More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50130000((4-Benzyl-benzyl)-[2-((S)-2,2-dimethyl-1-methylcar...)
Affinity DataIC50: 13nMAssay Description:Inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50130002([2-((S)-2,2-Dimethyl-1-methylcarbamoyl-propylcarba...)
Affinity DataIC50: 13nMAssay Description:Inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129984([4-(2-Chloro-benzyl)-benzyl]-[2-((S)-2,2-dimethyl-...)
Affinity DataIC50: 17nMAssay Description:Inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129989([2-((S)-2,2-Dimethyl-1-methylcarbamoyl-propylcarba...)
Affinity DataIC50: 18nMAssay Description:Inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM8465(CGS 27023 | CHEMBL514138 | hydroxamate analogue 1 ...)
Affinity DataIC50: 18nMAssay Description:Inhibitory activity against matrix metalloprotease-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129992((4-Benzyl-benzyl)-[2-((S)-2,2-dimethyl-1-methylcar...)
Affinity DataIC50: 19nMAssay Description:Inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50090259((4-Benzyl-benzyl)-[2-((S)-2,2-dimethyl-1-methylcar...)
Affinity DataIC50: 21nMAssay Description:Inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129997([2-((S)-2,2-Dimethyl-1-methylcarbamoyl-propylcarba...)
Affinity DataIC50: 24nMAssay Description:Inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50130004([2-((S)-2,2-Dimethyl-1-methylcarbamoyl-propylcarba...)
Affinity DataIC50: 29nMAssay Description:Inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129988((4-Benzyl-benzyl)-[2-((S)-2,2-dimethyl-1-methylcar...)
Affinity DataIC50: 30nMAssay Description:Inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129995([2-((S)-2,2-Dimethyl-1-methylcarbamoyl-propylcarba...)
Affinity DataIC50: 31nMAssay Description:Inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129996([2-((S)-2,2-Dimethyl-1-methylcarbamoyl-propylcarba...)
Affinity DataIC50: 37nMAssay Description:Inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50130001([2-((S)-2,2-Dimethyl-1-methylcarbamoyl-propylcarba...)
Affinity DataIC50: 43nMAssay Description:Inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50130008([2-((S)-2,2-Dimethyl-1-methylcarbamoyl-propylcarba...)
Affinity DataIC50: 44nMAssay Description:Inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129985([2-((S)-2,2-Dimethyl-1-methylcarbamoyl-propylcarba...)
Affinity DataIC50: 54nMAssay Description:Inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50130003([2-((S)-2,2-Dimethyl-1-methylcarbamoyl-propylcarba...)
Affinity DataIC50: 58nMAssay Description:Inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129983((4-Benzyl-benzyl)-{2-[(S)-2-(4-methoxy-phenyl)-1-m...)
Affinity DataIC50: 70nMAssay Description:Inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129993(Benzyl-[2-((S)-2,2-dimethyl-1-methylcarbamoyl-prop...)
Affinity DataIC50: 93nMAssay Description:Inhibition of matrix metalloprotease-12More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129993(Benzyl-[2-((S)-2,2-dimethyl-1-methylcarbamoyl-prop...)
Affinity DataIC50: 110nMAssay Description:Inhibition of matrix metalloprotease-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129990((4-Benzyl-benzyl)-[2-((S)-2,2-dimethyl-1-methylcar...)
Affinity DataIC50: 120nMAssay Description:Inhibitory activity against matrix metalloprotease-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129993(Benzyl-[2-((S)-2,2-dimethyl-1-methylcarbamoyl-prop...)
Affinity DataIC50: 210nMAssay Description:Inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129999((4-Benzyl-benzyl)-[2-((S)-2,2-dimethyl-1-methylcar...)
Affinity DataIC50: 280nMAssay Description:Inhibitory activity against matrix metalloprotease-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50130005((4-Benzyl-benzyl)-[2-((S)-2,2-dimethyl-1-methylcar...)
Affinity DataIC50: 300nMAssay Description:Inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50130002([2-((S)-2,2-Dimethyl-1-methylcarbamoyl-propylcarba...)
Affinity DataIC50: 350nMAssay Description:Inhibitory activity against matrix metalloprotease-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129984([4-(2-Chloro-benzyl)-benzyl]-[2-((S)-2,2-dimethyl-...)
Affinity DataIC50: 430nMAssay Description:Inhibitory activity against matrix metalloprotease-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50130000((4-Benzyl-benzyl)-[2-((S)-2,2-dimethyl-1-methylcar...)
Affinity DataIC50: 530nMAssay Description:Inhibitory activity against matrix metalloprotease-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129991([2-((S)-2,2-Dimethyl-1-methylcarbamoyl-propylcarba...)
Affinity DataIC50: 540nMAssay Description:Inhibitory activity against matrix metalloprotease-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
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