Compile Data Set for Download or QSAR
Report error Found 33 Enz. Inhib. hit(s) with all data for entry = 50013525
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50131549(4-Amino-3-bromo-5-cyano-2-hydroxy-benzoic acid | C...)
Affinity DataKd:  9.10E+5nMAssay Description:Protein-tyrosine phosphatase 1B (PTP 1B) site 2 Ligands were identified using [13C]-labeled protein and their Dissociation Constants were determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50131554(5-Hydroxy-6,8-dimethyl-quinoline-2-carboxylic acid...)
Affinity DataKd:  1.56E+7nMAssay Description:Protein-tyrosine phosphatase 1B (PTP 1B) site 2 Ligands were identified using [13C]-labeled protein and their Dissociation Constants were determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM48319(ISONICOTINIC ACID HYDRAZIDE P-AMINOSALICYLATE SALT...)
Affinity DataKd:  1.20E+6nMAssay Description:Protein-tyrosine phosphatase 1B (PTP 1B) site 2 Ligands were identified using [13C]-labeled protein and their Dissociation Constants were determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50131550((S)-4-((S)-1-amino-3-(4-(difluoro(phosphono)methyl...)
Affinity DataKi:  2.40nMAssay Description:Inhibitory activity against protein-tyrosine phosphatase 1B (PTP 1B) was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM13976(CHEMBL116605 | Aminobenzoic acid analog 5)
Affinity DataKi:  18nMAssay Description:Inhibitory activity against Protein-tyrosine phosphatase 1B (PTP 1B) was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase alpha(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50131550((S)-4-((S)-1-amino-3-(4-(difluoro(phosphono)methyl...)
Affinity DataKi:  24nMAssay Description:Inhibitory constant against T cell protein tyrosine phosphataseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50131547(2-[4-(2-Acetylamino-3-{4-[(2-carboxy-phenyl)-oxaly...)
Affinity DataKi:  40nMAssay Description:Inhibitory activity against Protein-tyrosine phosphatase 1B (PTP 1B) was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50131555(2-(4-(2-acetamido-3-(4-(1-carboxy-N-(2-carboxyphen...)
Affinity DataKi:  42nMAssay Description:Inhibitory activity against Protein-tyrosine phosphatase 1B (PTP 1B) was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase alpha(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM13976(CHEMBL116605 | Aminobenzoic acid analog 5)
Affinity DataKi:  65nMAssay Description:Inhibitory constant against T cell protein tyrosine phosphataseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase alpha(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50131555(2-(4-(2-acetamido-3-(4-(1-carboxy-N-(2-carboxyphen...)
Affinity DataKi:  73nMAssay Description:Inhibitory constant against T cell protein tyrosine phosphataseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM15819(1:1 mixture of diastereomers | CHEMBL55243 | 2-[(4...)
Affinity DataKi:  76nMAssay Description:Inhibitory activity against protein-tyrosine phosphatase 1B (PTP 1B) was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50131545((S)-2-(N-(4-(2-(allyloxycarbonylamino)-3-(4-(3-hyd...)
Affinity DataKi:  120nMAssay Description:Inhibitory activity against Protein-tyrosine phosphatase 1B (PTP 1B) was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase alpha(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50131553(2-[(4-{2-Acetylamino-2-[4-(3-hydroxy-2-nitro-pheno...)
Affinity DataKi:  120nMAssay Description:Inhibitory constant against T cell protein tyrosine phosphataseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50131553(2-[(4-{2-Acetylamino-2-[4-(3-hydroxy-2-nitro-pheno...)
Affinity DataKi:  130nMAssay Description:Inhibitory activity against Protein-tyrosine phosphatase 1B (PTP 1B) was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase alpha(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50131547(2-[4-(2-Acetylamino-3-{4-[(2-carboxy-phenyl)-oxaly...)
Affinity DataKi:  230nMAssay Description:Inhibitory constant against T cell protein tyrosine phosphataseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50131546(2-[(4-{2-Acetylamino-2-[4-(3-hydroxy-2-methylcarba...)
Affinity DataKi:  370nMAssay Description:Inhibitory activity against Protein-tyrosine phosphatase 1B (PTP 1B) was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase alpha(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM15819(1:1 mixture of diastereomers | CHEMBL55243 | 2-[(4...)
Affinity DataKi:  380nMAssay Description:Inhibitory constant against T cell protein tyrosine phosphataseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50131544(6-[4-(2-Acetylamino-3-{4-[(2-carboxy-phenyl)-oxaly...)
Affinity DataKi:  390nMAssay Description:Inhibitory activity against Protein-tyrosine phosphatase 1B (PTP 1B) was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase alpha(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50131545((S)-2-(N-(4-(2-(allyloxycarbonylamino)-3-(4-(3-hyd...)
Affinity DataKi:  470nMAssay Description:Inhibitory constant against T cell protein tyrosine phosphataseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50131548(4-[4-(2-Acetylamino-3-{4-[(2-carboxy-phenyl)-oxaly...)
Affinity DataKi:  560nMAssay Description:Inhibitory activity against Protein-tyrosine phosphatase 1B (PTP 1B) was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase alpha(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50131546(2-[(4-{2-Acetylamino-2-[4-(3-hydroxy-2-methylcarba...)
Affinity DataKi:  830nMAssay Description:Inhibitory constant against T cell protein tyrosine phosphataseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase alpha(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50131548(4-[4-(2-Acetylamino-3-{4-[(2-carboxy-phenyl)-oxaly...)
Affinity DataKi:  840nMAssay Description:Inhibitory constant against T cell protein tyrosine phosphataseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase alpha(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50131551(2-carboxy(2-ethyl-4-{2-methylcarboxamido-2-[4-(2-m...)
Affinity DataKi:  860nMAssay Description:Inhibitory constant against T cell protein tyrosine phosphataseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50131551(2-carboxy(2-ethyl-4-{2-methylcarboxamido-2-[4-(2-m...)
Affinity DataKi:  1.60E+3nMAssay Description:Inhibitory activity against Protein-tyrosine phosphatase 1B (PTP 1B) was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase alpha(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50131544(6-[4-(2-Acetylamino-3-{4-[(2-carboxy-phenyl)-oxaly...)
Affinity DataKi:  2.60E+3nMAssay Description:Inhibitory constant against T cell protein tyrosine phosphataseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein phosphatase 3 catalytic subunit alpha(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50131547(2-[4-(2-Acetylamino-3-{4-[(2-carboxy-phenyl)-oxaly...)
Affinity DataKi: >3.00E+3nMAssay Description:Inhibitory activity against (calcineurin) was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase C(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50131547(2-[4-(2-Acetylamino-3-{4-[(2-carboxy-phenyl)-oxaly...)
Affinity DataKi: >3.00E+3nMAssay Description:Inhibitory activity against CD45 tyrosine phosphatase was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase F(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50131547(2-[4-(2-Acetylamino-3-{4-[(2-carboxy-phenyl)-oxaly...)
Affinity DataKi: >3.00E+3nMAssay Description:Inhibitory activity against SH-domain containing phosphotyrosine phosphatase-2 (Tyrosine phosphatase SHP2) was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetM-phase inducer phosphatase 3(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50131547(2-[4-(2-Acetylamino-3-{4-[(2-carboxy-phenyl)-oxaly...)
Affinity DataKi: >3.00E+3nMAssay Description:Inhibitory activity against cell division cycle 25 degree C (Cdc25 C) was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase F(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50131545((S)-2-(N-(4-(2-(allyloxycarbonylamino)-3-(4-(3-hyd...)
Affinity DataKi:  9.60E+4nMAssay Description:Inhibitory activity against SH-domain containing phosphotyrosine phosphatase-2 (Tyrosine phosphatase SHP2) was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetM-phase inducer phosphatase 3(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50131545((S)-2-(N-(4-(2-(allyloxycarbonylamino)-3-(4-(3-hyd...)
Affinity DataKi:  1.78E+5nMAssay Description:Inhibitory activity against Cell division cycle 25 degree C was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein phosphatase 3 catalytic subunit alpha(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50131545((S)-2-(N-(4-(2-(allyloxycarbonylamino)-3-(4-(3-hyd...)
Affinity DataKi: >2.00E+5nMAssay Description:Inhibitory activity against (calcineurin) was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase C(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50131545((S)-2-(N-(4-(2-(allyloxycarbonylamino)-3-(4-(3-hyd...)
Affinity DataKi: >2.00E+5nMAssay Description:Inhibitory activity against CD45 tyrosine phosphatase was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed