Compile Data Set for Download or QSAR
Report error Found 36 Enz. Inhib. hit(s) with all data for entry = 50037189
TargetHistamine H3 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM22904(CHEMBL268229 | Alpha-Methylhistane-R | (2R)-1-(1H-...)
Affinity DataKi:  0.700nMAssay Description:Binding affinity to the human histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Rat)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM22566(CHEMBL129198 | 5-chloro-2-[(4-methylpiperazin-1-yl...)
Affinity DataKi:  2.40nMAssay Description:Binding affinity of compound towards rat histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Rat)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50133004((7-amino-1H-indol-2-yl)(4-methylpiperazin-1-yl)met...)
Affinity DataKi:  3.30nMAssay Description:Binding affinity of compound towards rat histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM22566(CHEMBL129198 | 5-chloro-2-[(4-methylpiperazin-1-yl...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]- histamine from the recombinant human histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50133018((4,5-dichloro-1H-indol-2-yl)(4-methylpiperazin-1-y...)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]- histamine from the recombinant human histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50132999((7-Methyl-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)...)
Affinity DataKi:  7nMAssay Description:Displacement of [3H]- histamine from the recombinant human histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50133005((5-bromo-1H-indol-2-yl)(4-methylpiperazin-1-yl)met...)
Affinity DataKi:  8nMAssay Description:Displacement of [3H]- histamine from the recombinant human histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50133004((7-amino-1H-indol-2-yl)(4-methylpiperazin-1-yl)met...)
Affinity DataKi:  8nMAssay Description:Displacement of [3H]- histamine from the recombinant human histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50133011((5,7-Dichloro-1H-indol-2-yl)-(4-methyl-piperazin-1...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]- histamine from the recombinant human histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM22884(2-[3-(1H-imidazol-5-yl)propyl]-1-(2-{[(5-methyl-1H...)
Affinity DataKi:  12.3nMAssay Description:Binding affinity to the human histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50133019((5,7-difluoro-1H-indol-2-yl)(4-methylpiperazin-1-y...)
Affinity DataKi:  14nMAssay Description:Displacement of [3H]- histamine from the recombinant human histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50133001((5-Amino-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-...)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]- histamine from the recombinant human histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50132996((5-Fluoro-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)...)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]- histamine from the recombinant human histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50133020((1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone |...)
Affinity DataKi:  17nMAssay Description:Displacement of [3H]- histamine from the recombinant human histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50133016((7-Chloro-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)...)
Affinity DataKi:  19nMAssay Description:Displacement of [3H]- histamine from the recombinant human histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50133007((5-hydroxy-1H-indol-2-yl)(4-methylpiperazin-1-yl)m...)
Affinity DataKi:  23nMAssay Description:Displacement of [3H]- histamine from the recombinant human histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)
Affinity DataKi:  25nMAssay Description:Binding affinity to the human histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50133003(UCL-2138 | CHEMBL129257 | 4-(3-Piperidin-1-yl-prop...)
Affinity DataKi:  25nMAssay Description:Binding affinity to the human histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)
Affinity DataKi:  27nMAssay Description:Binding affinity to the human histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50133008((5,7-Dimethyl-1H-indol-2-yl)-(4-methyl-piperazin-1...)
Affinity DataKi:  31nMAssay Description:Displacement of [3H]- histamine from the recombinant human histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50133009((4-bromo-1H-indol-2-yl)(4-methylpiperazin-1-yl)met...)
Affinity DataKi:  32nMAssay Description:Displacement of [3H]- histamine from the recombinant human histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50133002((1H-Indol-2-yl)-piperazin-1-yl-methanone | (1H-ind...)
Affinity DataKi:  38nMAssay Description:Displacement of [3H]- histamine from the recombinant human histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50133017((5-methyl-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)...)
Affinity DataKi:  46nMAssay Description:Displacement of [3H]- histamine from the recombinant human histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50133015((7-bromo-1H-indol-2-yl)(4-methylpiperazin-1-yl)met...)
Affinity DataKi:  61nMAssay Description:Displacement of [3H]- histamine from the recombinant human histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM22884(2-[3-(1H-imidazol-5-yl)propyl]-1-(2-{[(5-methyl-1H...)
Affinity DataKi:  67nMAssay Description:Binding affinity to the human histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM22888(1-[4-(1H-imidazol-5-yl)butyl]-3-methylthiourea | C...)
Affinity DataKi:  84nMAssay Description:Binding affinity to the human histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM22904(CHEMBL268229 | Alpha-Methylhistane-R | (2R)-1-(1H-...)
Affinity DataKi:  146nMAssay Description:Binding affinity to the human histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50133006((6-Bromo-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-...)
Affinity DataKi:  147nMAssay Description:Displacement of [3H]- histamine from the recombinant human histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM22888(1-[4-(1H-imidazol-5-yl)butyl]-3-methylthiourea | C...)
Affinity DataKi:  180nMAssay Description:Binding affinity to the human histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50133010((1H-Indol-2-yl)-(3-methyl-piperazin-1-yl)-methanon...)
Affinity DataKi:  202nMAssay Description:Displacement of [3H]- histamine from the recombinant human histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50133012((4-Ethyl-piperazin-1-yl)-(1H-indol-2-yl)-methanone...)
Affinity DataKi:  260nMAssay Description:Displacement of [3H]- histamine from the recombinant human histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50132997((5-Methoxy-1H-indol-2-yl)-(4-methyl-piperazin-1-yl...)
Affinity DataKi:  3.00E+3nMAssay Description:Displacement of [3H]- histamine from the recombinant human histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50133013((1H-Indol-2-yl)-(4-phenethyl-piperazin-1-yl)-metha...)
Affinity DataKi:  7.00E+3nMAssay Description:Displacement of [3H]- histamine from the recombinant human histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50133003(UCL-2138 | CHEMBL129257 | 4-(3-Piperidin-1-yl-prop...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to the human histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50133014((1-Methyl-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]- histamine from the recombinant human histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50132998(2-(4-Methyl-piperazin-1-ylmethyl)-1H-indole | CHEM...)
Affinity DataKi:  1.00E+4nMAssay Description:Displacement of [3H]- histamine from the recombinant human histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed