Compile Data Set for Download or QSAR
Report error Found 45 Enz. Inhib. hit(s) with all data for entry = 50013701
TargetProthrombin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50133524(N-(2-Aminomethyl-5-chloro-benzyl)-2-{6-chloro-3-[2...)
Affinity DataKi:  0.00340nMAssay Description:Inhibitory constant evaluated against thrombin (Factor IIa)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50133529(N-(2-Aminomethyl-5-chloro-benzyl)-2-(6-methyl-2-ox...)
Affinity DataKi:  0.0460nMAssay Description:Inhibitory constant evaluated against thrombin (Factor IIa)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50133521(N-[2-(2-Amino-ethyl)-5-chloro-benzyl]-2-(6-methyl-...)
Affinity DataKi:  0.0500nMAssay Description:Inhibitory constant evaluated against thrombin (Factor IIa)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50133520(N-(2-Aminomethyl-5-chloro-benzyl)-2-(6-methyl-2-ox...)
Affinity DataKi:  0.130nMAssay Description:Inhibitory constant evaluated against thrombin (Factor IIa)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50067796(L-374087 | N-(6-Amino-2-methyl-pyridin-3-ylmethyl)...)
Affinity DataKi:  0.5nMAssay Description:Inhibitory constant evaluated against thrombin (Factor IIa)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50069190(N-(1-Carbamimidoyl-piperidin-4-ylmethyl)-2-(6-meth...)
Affinity DataKi:  0.5nMAssay Description:Inhibitory constant evaluated against thrombin (Factor IIa)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50067797(N-(6-Amino-2-methyl-pyridin-3-ylmethyl)-2-(6-methy...)
Affinity DataKi:  0.800nMAssay Description:Inhibitory constant evaluated against thrombin (Factor IIa)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50133517((S)-1-((R)-2-Amino-3-phenyl-propionyl)-pyrrolidine...)
Affinity DataKi:  3.30nMAssay Description:Inhibitory constant evaluated against thrombin (Factor IIa)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50133528(3-(4-Aminomethyl-phenyl)-N-cyclopentyl-N-methyl-2-...)
Affinity DataKi:  3.30nMAssay Description:Inhibitory constant evaluated against thrombin (Factor IIa)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50133519(N-[2-(2-Amino-ethyl)-benzyl]-2-(6-methyl-2-oxo-3-p...)
Affinity DataKi:  4.10nMAssay Description:Inhibitory constant evaluated against thrombin (Factor IIa)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50133525(N-(4-Amino-cyclohexylmethyl)-2-(6-methyl-2-oxo-3-p...)
Affinity DataKi:  4.60nMAssay Description:Inhibitory constant evaluated against thrombin (Factor IIa)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50133526(N-(2-Aminomethyl-benzyl)-2-(6-methyl-2-oxo-3-pheny...)
Affinity DataKi:  5.20nMAssay Description:Inhibitory constant evaluated against thrombin (Factor IIa)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50133516(3-(4-Aminomethyl-phenyl)-N-cyclopentyl-2-(6-methox...)
Affinity DataKi:  6.60nMAssay Description:Inhibitory constant evaluated against thrombin (Factor IIa)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122184(N-(3-Chloro-benzyl)-2-(6-methyl-2-oxo-3-phenylmeth...)
Affinity DataKi:  7.10nMAssay Description:Inhibitory constant evaluated against thrombin (Factor IIa)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50133532((S)-1-((R)-2-Amino-3,3-diphenyl-propionyl)-pyrroli...)
Affinity DataKi:  39nMAssay Description:Inhibitory constant evaluated against thrombin (Factor IIa)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50133522(N-(4-Aminomethyl-benzyl)-2-(6-methyl-2-oxo-3-pheny...)
Affinity DataKi:  49nMAssay Description:Inhibitory constant evaluated against thrombin (Factor IIa)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50133527((S)-1-((R)-2-Amino-3-phenyl-propionyl)-pyrrolidine...)
Affinity DataKi:  62nMAssay Description:Inhibitory constant evaluated against thrombin (Factor IIa)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50133515(N-Benzyl-2-(6-methyl-2-oxo-3-phenylmethanesulfonyl...)
Affinity DataKi:  130nMAssay Description:Inhibitory constant evaluated against thrombin (Factor IIa)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50133531(1-((S)-2-Amino-1-(R)-oxo-3-phenyl-propyl)-pyrrolid...)
Affinity DataKi:  250nMAssay Description:Inhibitory constant evaluated against thrombin (Factor IIa)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50133533((S)-1-((R)-2-Amino-3-phenyl-propionyl)-pyrrolidine...)
Affinity DataKi:  313nMAssay Description:Inhibitory constant evaluated against thrombin (Factor IIa)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50133524(N-(2-Aminomethyl-5-chloro-benzyl)-2-{6-chloro-3-[2...)
Affinity DataKi:  415nMAssay Description:Inhibitory constant evaluated against trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50133530(N-(2-Amino-benzyl)-2-(6-methyl-2-oxo-3-phenylmetha...)
Affinity DataKi:  470nMAssay Description:Inhibitory constant evaluated against thrombin (Factor IIa)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50133523(N-(3-Aminomethyl-benzyl)-2-(6-methyl-2-oxo-3-pheny...)
Affinity DataKi:  490nMAssay Description:Inhibitory constant evaluated against thrombin (Factor IIa)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50069190(N-(1-Carbamimidoyl-piperidin-4-ylmethyl)-2-(6-meth...)
Affinity DataKi:  570nMAssay Description:Inhibitory constant evaluated against trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50133522(N-(4-Aminomethyl-benzyl)-2-(6-methyl-2-oxo-3-pheny...)
Affinity DataKi:  1.30E+3nMAssay Description:Inhibitory constant evaluated against trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50133520(N-(2-Aminomethyl-5-chloro-benzyl)-2-(6-methyl-2-ox...)
Affinity DataKi:  1.60E+3nMAssay Description:Inhibitory constant evaluated against trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50067797(N-(6-Amino-2-methyl-pyridin-3-ylmethyl)-2-(6-methy...)
Affinity DataKi:  1.80E+3nMAssay Description:Inhibitory constant evaluated against trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50133529(N-(2-Aminomethyl-5-chloro-benzyl)-2-(6-methyl-2-ox...)
Affinity DataKi:  1.85E+3nMAssay Description:Inhibitory constant evaluated against trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50133525(N-(4-Amino-cyclohexylmethyl)-2-(6-methyl-2-oxo-3-p...)
Affinity DataKi:  3.00E+3nMAssay Description:Inhibitory constant evaluated against trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50067796(L-374087 | N-(6-Amino-2-methyl-pyridin-3-ylmethyl)...)
Affinity DataKi:  3.20E+3nMAssay Description:Inhibitory constant evaluated against trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50133518((S)-1-((R)-2-Amino-3-phenyl-propionyl)-pyrrolidine...)
Affinity DataKi:  4.60E+3nMAssay Description:Inhibitory constant evaluated against thrombin (Factor IIa)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50133517((S)-1-((R)-2-Amino-3-phenyl-propionyl)-pyrrolidine...)
Affinity DataKi:  6.20E+3nMAssay Description:Inhibitory constant evaluated against trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50133528(3-(4-Aminomethyl-phenyl)-N-cyclopentyl-N-methyl-2-...)
Affinity DataKi:  6.30E+3nMAssay Description:Inhibitory constant evaluated against trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50133516(3-(4-Aminomethyl-phenyl)-N-cyclopentyl-2-(6-methox...)
Affinity DataKi:  1.42E+4nMAssay Description:Inhibitory constant evaluated against trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122184(N-(3-Chloro-benzyl)-2-(6-methyl-2-oxo-3-phenylmeth...)
Affinity DataKi:  2.00E+4nMAssay Description:Inhibitory constant evaluated against trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50133523(N-(3-Aminomethyl-benzyl)-2-(6-methyl-2-oxo-3-pheny...)
Affinity DataKi:  2.30E+4nMAssay Description:Inhibitory constant evaluated against trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50133521(N-[2-(2-Amino-ethyl)-5-chloro-benzyl]-2-(6-methyl-...)
Affinity DataKi:  3.70E+4nMAssay Description:Inhibitory constant evaluated against trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50133526(N-(2-Aminomethyl-benzyl)-2-(6-methyl-2-oxo-3-pheny...)
Affinity DataKi:  6.70E+4nMAssay Description:Inhibitory constant evaluated against trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50133531(1-((S)-2-Amino-1-(R)-oxo-3-phenyl-propyl)-pyrrolid...)
Affinity DataKi:  8.90E+4nMAssay Description:Inhibitory constant evaluated against trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50133533((S)-1-((R)-2-Amino-3-phenyl-propionyl)-pyrrolidine...)
Affinity DataKi:  1.06E+5nMAssay Description:Inhibitory constant evaluated against trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50133527((S)-1-((R)-2-Amino-3-phenyl-propionyl)-pyrrolidine...)
Affinity DataKi:  2.52E+5nMAssay Description:Inhibitory constant evaluated against trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50133519(N-[2-(2-Amino-ethyl)-benzyl]-2-(6-methyl-2-oxo-3-p...)
Affinity DataKi:  4.37E+5nMAssay Description:Inhibitory constant evaluated against trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50133515(N-Benzyl-2-(6-methyl-2-oxo-3-phenylmethanesulfonyl...)
Affinity DataKi:  4.66E+5nMAssay Description:Inhibitory constant evaluated against trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50133518((S)-1-((R)-2-Amino-3-phenyl-propionyl)-pyrrolidine...)
Affinity DataKi: >1.00E+6nMAssay Description:Inhibitory constant evaluated against trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50133530(N-(2-Amino-benzyl)-2-(6-methyl-2-oxo-3-phenylmetha...)
Affinity DataKi: >1.00E+6nMAssay Description:Inhibitory constant evaluated against trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed