Compile Data Set for Download or QSAR
Report error Found 18 Enz. Inhib. hit(s) with all data for entry = 724
TargetEpidermal growth factor receptor(Human)
Glaxosmithkline

LigandPNGBDBM5446(Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...)
Affinity DataIC50: 1nMpH: 7.5 T: 2°CAssay Description:Enzymatic reactions were initiated by adding kinase to the reaction mixture containing ATP, [gamma-33P] ATP, peptide substrate and test inhibitor com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2005
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
Glaxosmithkline

LigandPNGBDBM5447(ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...)
Affinity DataIC50: 1nMpH: 7.5 T: 2°CAssay Description:Enzymatic reactions were initiated by adding kinase to the reaction mixture containing ATP, [gamma-33P] ATP, peptide substrate and test inhibitor com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2005
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
Glaxosmithkline

LigandPNGBDBM5443(N-[4-(benzyloxy)-3-chlorophenyl]-6-(2-{[(2-methane...)
Affinity DataIC50: 8nMpH: 7.5 T: 2°CAssay Description:Enzymatic reactions were initiated by adding kinase to the reaction mixture containing ATP, [gamma-33P] ATP, peptide substrate and test inhibitor com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2005
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Glaxosmithkline

LigandPNGBDBM5445(N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...)
Affinity DataIC50: 9nMpH: 7.5 T: 2°CAssay Description:Enzymatic reactions were initiated by adding kinase to the reaction mixture containing ATP, [gamma-33P] ATP, peptide substrate and test inhibitor com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2005
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Glaxosmithkline

LigandPNGBDBM5444(N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...)
Affinity DataIC50: 10nMpH: 7.5 T: 2°CAssay Description:Enzymatic reactions were initiated by adding kinase to the reaction mixture containing ATP, [gamma-33P] ATP, peptide substrate and test inhibitor com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2005
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Glaxosmithkline

LigandPNGBDBM5445(N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...)
Affinity DataIC50: 10nMpH: 7.5 T: 2°CAssay Description:Enzymatic reactions were initiated by adding kinase to the reaction mixture containing ATP, [gamma-33P] ATP, peptide substrate and test inhibitor com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2005
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Glaxosmithkline

LigandPNGBDBM5444(N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...)
Affinity DataIC50: 14nMpH: 7.5 T: 2°CAssay Description:Enzymatic reactions were initiated by adding kinase to the reaction mixture containing ATP, [gamma-33P] ATP, peptide substrate and test inhibitor com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2005
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Glaxosmithkline

LigandPNGBDBM5443(N-[4-(benzyloxy)-3-chlorophenyl]-6-(2-{[(2-methane...)
Affinity DataIC50: 14nMpH: 7.5 T: 2°CAssay Description:Enzymatic reactions were initiated by adding kinase to the reaction mixture containing ATP, [gamma-33P] ATP, peptide substrate and test inhibitor com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2005
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Glaxosmithkline

LigandPNGBDBM5441(N-(1-benzyl-1H-indazol-5-yl)-6-(2-{[(2-methanesulf...)
Affinity DataIC50: 28nMpH: 7.5 T: 2°CAssay Description:Enzymatic reactions were initiated by adding kinase to the reaction mixture containing ATP, [gamma-33P] ATP, peptide substrate and test inhibitor com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2005
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Glaxosmithkline

LigandPNGBDBM5439(N-(3-chloro-4-fluorophenyl)-6-(2-{[(2-methanesulfo...)
Affinity DataIC50: 35nMpH: 7.5 T: 2°CAssay Description:Enzymatic reactions were initiated by adding kinase to the reaction mixture containing ATP, [gamma-33P] ATP, peptide substrate and test inhibitor com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2005
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Glaxosmithkline

LigandPNGBDBM5440(N-[4-(benzyloxy)phenyl]-6-(2-{[(2-methanesulfonyle...)
Affinity DataIC50: 48nMpH: 7.5 T: 2°CAssay Description:Enzymatic reactions were initiated by adding kinase to the reaction mixture containing ATP, [gamma-33P] ATP, peptide substrate and test inhibitor com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2005
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Glaxosmithkline

LigandPNGBDBM5441(N-(1-benzyl-1H-indazol-5-yl)-6-(2-{[(2-methanesulf...)
Affinity DataIC50: 71nMpH: 7.5 T: 2°CAssay Description:Enzymatic reactions were initiated by adding kinase to the reaction mixture containing ATP, [gamma-33P] ATP, peptide substrate and test inhibitor com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2005
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Glaxosmithkline

LigandPNGBDBM5440(N-[4-(benzyloxy)phenyl]-6-(2-{[(2-methanesulfonyle...)
Affinity DataIC50: 82nMpH: 7.5 T: 2°CAssay Description:Enzymatic reactions were initiated by adding kinase to the reaction mixture containing ATP, [gamma-33P] ATP, peptide substrate and test inhibitor com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2005
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Glaxosmithkline

LigandPNGBDBM5439(N-(3-chloro-4-fluorophenyl)-6-(2-{[(2-methanesulfo...)
Affinity DataIC50: 200nMpH: 7.5 T: 2°CAssay Description:Enzymatic reactions were initiated by adding kinase to the reaction mixture containing ATP, [gamma-33P] ATP, peptide substrate and test inhibitor com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2005
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Glaxosmithkline

LigandPNGBDBM5447(ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...)
Affinity DataIC50: 240nMpH: 7.5 T: 2°CAssay Description:Enzymatic reactions were initiated by adding kinase to the reaction mixture containing ATP, [gamma-33P] ATP, peptide substrate and test inhibitor com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2005
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Glaxosmithkline

LigandPNGBDBM5442(6-(2-{[(2-methanesulfonylethyl)amino]methyl}-1,3-t...)
Affinity DataIC50: 540nMpH: 7.5 T: 2°CAssay Description:Enzymatic reactions were initiated by adding kinase to the reaction mixture containing ATP, [gamma-33P] ATP, peptide substrate and test inhibitor com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2005
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Glaxosmithkline

LigandPNGBDBM5442(6-(2-{[(2-methanesulfonylethyl)amino]methyl}-1,3-t...)
Affinity DataIC50: 550nMpH: 7.5 T: 2°CAssay Description:Enzymatic reactions were initiated by adding kinase to the reaction mixture containing ATP, [gamma-33P] ATP, peptide substrate and test inhibitor com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2005
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Glaxosmithkline

LigandPNGBDBM5446(Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...)
Affinity DataIC50: 760nMpH: 7.5 T: 2°CAssay Description:Enzymatic reactions were initiated by adding kinase to the reaction mixture containing ATP, [gamma-33P] ATP, peptide substrate and test inhibitor com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2005
Entry Details Article
PubMed