Compile Data Set for Download or QSAR
Report error Found 22 Enz. Inhib. hit(s) with all data for entry = 50000291
TargetIntegrin alpha-IIb/beta-3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50004058(N-(butylsulfonyl)-O-(4-piperidin-4-ylbutyl)-L-tyro...)
Affinity DataIC50: 5nMAssay Description:Inhibition of [125I]fibrinogen binding to fibrinogen receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50004058(N-(butylsulfonyl)-O-(4-piperidin-4-ylbutyl)-L-tyro...)
Affinity DataIC50: 11nMAssay Description:In vitro inhibition of ADP-mediated human gel filtered platelet aggregation.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50004071(CHEMBL420966 | (S)-2-Phenylmethanesulfonylamino-3-...)
Affinity DataIC50: 18nMAssay Description:In vitro inhibition of ADP-mediated human gel filtered platelet aggregation.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50004061((S)-2-Hexanoylamino-3-[4-(4-piperidin-4-yl-butoxy)...)
Affinity DataIC50: 35nMAssay Description:In vitro inhibition of ADP-mediated human gel filtered platelet aggregation.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50004060(CHEMBL85152 | 2-Benzyloxycarbonylamino-3-[4-(4-pip...)
Affinity DataIC50: 260nMAssay Description:In vitro inhibition of ADP-mediated human gel filtered platelet aggregation.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50004065(CHEMBL86115 | (S)-3-[4-(6-Amino-hexyloxy)-phenyl]-...)
Affinity DataIC50: 780nMAssay Description:In vitro inhibition of ADP-mediated human gel filtered platelet aggregation.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50004066(CHEMBL85261 | 3-[4-(6-Amino-hexyloxy)-phenyl]-2-ph...)
Affinity DataIC50: 2.00E+3nMAssay Description:In vitro inhibition of ADP-mediated human gel filtered platelet aggregation.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50004062(CHEMBL85544 | (S)-3-[4-(7-Amino-heptyloxy)-phenyl]...)
Affinity DataIC50: 2.60E+3nMAssay Description:In vitro inhibition of ADP-mediated human gel filtered platelet aggregation.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50004064(CHEMBL83079 | 3-[4-(6-Amino-hexyloxy)-phenyl]-2-he...)
Affinity DataIC50: 3.80E+3nMAssay Description:In vitro inhibition of ADP-mediated human gel filtered platelet aggregation.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50004067(CHEMBL86193 | 3-[4-(6-Amino-hexyloxy)-phenyl]-2-(3...)
Affinity DataIC50: 8.00E+3nMAssay Description:In vitro inhibition of ADP-mediated human gel filtered platelet aggregation.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50004059((S)-2-Benzyloxycarbonylamino-3-[4-(3-tert-butylami...)
Affinity DataIC50: 2.20E+4nMAssay Description:In vitro inhibition of ADP-mediated human gel filtered platelet aggregation.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50241180(3-[2-(2-Amino-5-guanidino-pentanoylamino)-acetylam...)
Affinity DataIC50: 2.60E+4nMAssay Description:In vitro inhibition of ADP-mediated human gel filtered platelet aggregation.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50004070((S)-3-[4-(6-Amino-hexyloxy)-phenyl]-2-benzyloxycar...)
Affinity DataIC50: 2.60E+4nMAssay Description:In vitro inhibition of ADP-mediated human gel filtered platelet aggregation.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50004072(CHEMBL83247 | 2-Benzyloxycarbonylamino-3-[4-(3-ter...)
Affinity DataIC50: 2.70E+4nMAssay Description:In vitro inhibition of ADP-mediated human gel filtered platelet aggregation.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50004069((S)-2-Amino-3-[4-(6-amino-hexyloxy)-phenyl]-propio...)
Affinity DataIC50: 3.50E+4nMAssay Description:In vitro inhibition of ADP-mediated human gel filtered platelet aggregation.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50004063(CHEMBL86080 | 3-[4-(5-Amino-pentyloxy)-phenyl]-2-b...)
Affinity DataIC50: 3.60E+4nMAssay Description:In vitro inhibition of ADP-mediated human gel filtered platelet aggregation.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50004056(3-[4-(8-Amino-octyloxy)-phenyl]-2-benzyloxycarbony...)
Affinity DataIC50: 4.00E+4nMAssay Description:In vitro inhibition of ADP-mediated human gel filtered platelet aggregation.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50004057(CHEMBL420043 | 3-[4-(6-Amino-hexyloxy)-phenyl]-pro...)
Affinity DataIC50: 1.00E+5nMAssay Description:In vitro inhibition of ADP-mediated human gel filtered platelet aggregation.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50004058(N-(butylsulfonyl)-O-(4-piperidin-4-ylbutyl)-L-tyro...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of HUVEC attachment to human vitronectinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50004058(N-(butylsulfonyl)-O-(4-piperidin-4-ylbutyl)-L-tyro...)
Affinity DataIC50: 2.60E+5nMAssay Description:Inhibition of HUVEC attachment to human fibrinogenMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-5/beta-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50004058(N-(butylsulfonyl)-O-(4-piperidin-4-ylbutyl)-L-tyro...)
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of HUVEC attachment to human fibronectinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50004068(CHEMBL85951 | 2-Benzyloxycarbonylamino-3-[4-(3-phe...)
Affinity DataIC50: 1.00E+6nMAssay Description:In vitro inhibition of ADP-mediated human gel filtered platelet aggregation.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed