Compile Data Set for Download or QSAR
Report error Found 39 Enz. Inhib. hit(s) with all data for entry = 50014104
TargetIntegrin alpha-5/beta-1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50138318((5S,8S)-3-[(S)-2-Carboxy-2-(2,4,6-trimethyl-benzen...)
Affinity DataIC50: 0.180nMAssay Description:Alpha-5 beta-1 antagonism using an ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-5/beta-1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50138313((5S,8S)-8-[(1H-Benzoimidazol-2-ylamino)-methyl]-3-...)
Affinity DataIC50: 0.390nMAssay Description:Alpha-5 beta-1 antagonism using an ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-5/beta-1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50138321((5S,8S)-8-[(1H-Benzoimidazol-2-ylamino)-methyl]-3-...)
Affinity DataIC50: 1.40nMAssay Description:Alpha-5 beta-1 antagonism using an ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-5/beta-1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50138310((5S,8S)-3-[(S)-2-Carboxy-2-(2,4,6-trimethyl-benzen...)
Affinity DataIC50: 13nMAssay Description:Alpha-5 beta-1 antagonism using an ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-5/beta-1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50138306((5S,8S)-3-[(S)-2-Carboxy-2-(2,4,6-trimethyl-benzen...)
Affinity DataIC50: 14nMAssay Description:Alpha-5 beta-1 antagonism using an ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50138324((S)-2-(3,5-Dichloro-biphenyl-4-sulfonyl)-3-({8-[(1...)
Affinity DataIC50: 17nMAssay Description:Evaluated in an functional alpha-v beta-3 antagonism assay, involving adhesion of beta-3-transfected 293 cells to fibrinogen (alpha-v beta-3 293 beta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-5/beta-1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50138319((5S,8S)-3-[(S)-2-Carboxy-2-(2,4,6-trimethyl-benzen...)
Affinity DataIC50: 18nMAssay Description:Alpha-5 beta-1 antagonism using an ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-5/beta-1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50138323((5S,8S)-3-[(S)-2-Carboxy-2-(2,4,6-trimethyl-benzen...)
Affinity DataIC50: 21nMAssay Description:Alpha-5 beta-1 antagonism using an ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50138308((5S,8S)-3-[(S)-2-Carboxy-2-(2,4,6-trimethyl-benzen...)
Affinity DataIC50: 32nMAssay Description:Evaluated in an functional alpha-v beta-3 antagonism assay, involving adhesion of beta-3-transfected 293 cells to fibrinogen (alpha-v beta-3 293 beta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50138321((5S,8S)-8-[(1H-Benzoimidazol-2-ylamino)-methyl]-3-...)
Affinity DataIC50: 34nMAssay Description:Evaluated in an functional alpha-v beta-3 antagonism assay, involving adhesion of beta-3-transfected 293 cells to fibrinogen (alpha-v beta-3 293 beta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50138314((S)-2-(2,6-Dichloro-benzenesulfonyl)-3-({8-[(1H-im...)
Affinity DataIC50: 34nMAssay Description:Evaluated in an functional alpha-v beta-3 antagonism assay, involving adhesion of beta-3-transfected 293 cells to fibrinogen (alpha-v beta-3 293 beta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-5/beta-1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50138308((5S,8S)-3-[(S)-2-Carboxy-2-(2,4,6-trimethyl-benzen...)
Affinity DataIC50: 39nMAssay Description:Alpha-5 beta-1 antagonism using an ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50138319((5S,8S)-3-[(S)-2-Carboxy-2-(2,4,6-trimethyl-benzen...)
Affinity DataIC50: 41nMAssay Description:Evaluated in an functional alpha-v beta-3 antagonism assay, involving adhesion of beta-3-transfected 293 cells to fibrinogen (alpha-v beta-3 293 beta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50138318((5S,8S)-3-[(S)-2-Carboxy-2-(2,4,6-trimethyl-benzen...)
Affinity DataIC50: 49nMAssay Description:Evaluated in an functional alpha-v beta-3 antagonism assay, involving adhesion of beta-3-transfected 293 cells to fibrinogen (alpha-v beta-3 293 beta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50138316((S)-2-(2,6-Dimethyl-benzenesulfonyl)-3-({8-[(1H-im...)
Affinity DataIC50: 56nMAssay Description:Evaluated in an functional alpha-v beta-3 antagonism assay, involving adhesion of beta-3-transfected 293 cells to fibrinogen (alpha-v beta-3 293 beta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50138323((5S,8S)-3-[(S)-2-Carboxy-2-(2,4,6-trimethyl-benzen...)
Affinity DataIC50: 57nMAssay Description:Evaluated in an functional alpha-v beta-3 antagonism assay, involving adhesion of beta-3-transfected 293 cells to fibrinogen (alpha-v beta-3 293 beta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50138310((5S,8S)-3-[(S)-2-Carboxy-2-(2,4,6-trimethyl-benzen...)
Affinity DataIC50: 57nMAssay Description:Evaluated in an functional alpha-v beta-3 antagonism assay, involving adhesion of beta-3-transfected 293 cells to fibrinogen (alpha-v beta-3 293 beta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50138320((5S,8S)-8-[(1H-Benzoimidazol-2-ylamino)-methyl]-3-...)
Affinity DataIC50: 74nMAssay Description:Evaluated in an functional alpha-v beta-3 antagonism assay, involving adhesion of beta-3-transfected 293 cells to fibrinogen (alpha-v beta-3 293 beta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50138313((5S,8S)-8-[(1H-Benzoimidazol-2-ylamino)-methyl]-3-...)
Affinity DataIC50: 87nMAssay Description:Evaluated in an functional alpha-v beta-3 antagonism assay, involving adhesion of beta-3-transfected 293 cells to fibrinogen (alpha-v beta-3 293 beta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50138315((S)-2-(3,5-Dimethyl-biphenyl-4-sulfonyl)-3-({8-[(1...)
Affinity DataIC50: 93nMAssay Description:Evaluated in an functional alpha-v beta-3 antagonism assay, involving adhesion of beta-3-transfected 293 cells to fibrinogen (alpha-v beta-3 293 beta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50138322((S)-3-{[8-(1H-Imidazol-2-ylcarbamoyl)-1-oxa-2-aza-...)
Affinity DataIC50: 106nMAssay Description:Evaluated in an functional alpha-v beta-3 antagonism assay, involving adhesion of beta-3-transfected 293 cells to fibrinogen (alpha-v beta-3 293 beta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50138309((S)-2-Benzenesulfonyl-3-({8-[(1H-imidazol-2-ylamin...)
Affinity DataIC50: 130nMAssay Description:Evaluated in an functional alpha-v beta-3 antagonism assay, involving adhesion of beta-3-transfected 293 cells to fibrinogen (alpha-v beta-3 293 beta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50138306((5S,8S)-3-[(S)-2-Carboxy-2-(2,4,6-trimethyl-benzen...)
Affinity DataIC50: 130nMAssay Description:Evaluated in an functional alpha-v beta-3 antagonism assay, involving adhesion of beta-3-transfected 293 cells to fibrinogen (alpha-v beta-3 293 beta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50138307((S)-3-({8-[(1,4,5,6-Tetrahydro-pyrimidin-2-ylamino...)
Affinity DataIC50: 160nMAssay Description:Evaluated in an functional alpha-v beta-3 antagonism assay, involving adhesion of beta-3-transfected 293 cells to fibrinogen (alpha-v beta-3 293 beta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50138311((S)-3-({8-[(1H-Imidazol-2-ylamino)-methyl]-1-oxa-2...)
Affinity DataIC50: 170nMAssay Description:Evaluated in an functional alpha-v beta-3 antagonism assay, involving adhesion of beta-3-transfected 293 cells to fibrinogen (alpha-v beta-3 293 beta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-5/beta-1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50138317((S)-3-({8-[(1H-Benzoimidazol-2-ylamino)-methyl]-1-...)
Affinity DataIC50: 170nMAssay Description:Alpha-5 beta-1 antagonism using an ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50138312((S)-3-({(5S,8S)-8-[(1H-Imidazol-2-ylamino)-methyl]...)
Affinity DataIC50: 180nMAssay Description:Evaluated in an functional alpha-v beta-3 antagonism assay, involving adhesion of beta-3-transfected 293 cells to fibrinogen (alpha-v beta-3 293 beta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-5/beta-1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50138312((S)-3-({(5S,8S)-8-[(1H-Imidazol-2-ylamino)-methyl]...)
Affinity DataIC50: 230nMAssay Description:Alpha-5 beta-1 antagonism using an ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-5/beta-1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50138324((S)-2-(3,5-Dichloro-biphenyl-4-sulfonyl)-3-({8-[(1...)
Affinity DataIC50: 310nMAssay Description:Alpha-5 beta-1 antagonism using an ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50138317((S)-3-({8-[(1H-Benzoimidazol-2-ylamino)-methyl]-1-...)
Affinity DataIC50: 440nMAssay Description:Evaluated in an functional alpha-v beta-3 antagonism assay, involving adhesion of beta-3-transfected 293 cells to fibrinogen (alpha-v beta-3 293 beta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-5/beta-1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50138315((S)-2-(3,5-Dimethyl-biphenyl-4-sulfonyl)-3-({8-[(1...)
Affinity DataIC50: 670nMAssay Description:Alpha-5 beta-1 antagonism using an ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50421658(CHEMBL2111839)
Affinity DataIC50: 1.00E+3nMAssay Description:Evaluated in an functional alpha-v beta-3 antagonism assay, involving adhesion of beta-3-transfected 293 cells to fibrinogen (alpha-v beta-3 293 beta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-5/beta-1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50421658(CHEMBL2111839)
Affinity DataIC50: 1.20E+3nMAssay Description:Alpha-5 beta-1 antagonism using an ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-5/beta-1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50138311((S)-3-({8-[(1H-Imidazol-2-ylamino)-methyl]-1-oxa-2...)
Affinity DataIC50: 1.50E+3nMAssay Description:Alpha-5 beta-1 antagonism using an ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-5/beta-1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50138316((S)-2-(2,6-Dimethyl-benzenesulfonyl)-3-({8-[(1H-im...)
Affinity DataIC50: 1.80E+3nMAssay Description:Alpha-5 beta-1 antagonism using an ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-5/beta-1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50138322((S)-3-{[8-(1H-Imidazol-2-ylcarbamoyl)-1-oxa-2-aza-...)
Affinity DataIC50: 2.70E+3nMAssay Description:Alpha-5 beta-1 antagonism using an ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-5/beta-1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50138314((S)-2-(2,6-Dichloro-benzenesulfonyl)-3-({8-[(1H-im...)
Affinity DataIC50: 3.00E+3nMAssay Description:Alpha-5 beta-1 antagonism using an ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-5/beta-1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50138309((S)-2-Benzenesulfonyl-3-({8-[(1H-imidazol-2-ylamin...)
Affinity DataIC50: 4.70E+3nMAssay Description:Alpha-5 beta-1 antagonism using an ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50138313((5S,8S)-8-[(1H-Benzoimidazol-2-ylamino)-methyl]-3-...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of platelet aggregation in human platelet-rich plasma by alphaIIb-beta3 integrinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed