Compile Data Set for Download or QSAR
Report error Found 6 Enz. Inhib. hit(s) with all data for entry = 2609
TargetBifunctional purine biosynthesis protein ATIC(Human)
The Scripps Research Institute

LigandPNGBDBM22584({4-[5-bromo-3-(sulfooxy)-1H-indol-2-yl]-13-chloro-...)
Affinity DataIC50: 1.40E+3nMpH: 7.5 T: 2°CAssay Description:The human ATIC enzyme was used for the inhibition assay. The assay buffer was flushed with nitrogen to minimize oxidization of cofactor 10-f-THF. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2008
Entry Details Article
PubMed
TargetBifunctional purine biosynthesis protein ATIC(Human)
The Scripps Research Institute

LigandPNGBDBM22580(5-chloro-2-{5-hydroxy-3-methyl-4-[(E)-2-[4-(4-meth...)
Affinity DataIC50: 3.30E+3nMpH: 7.5 T: 2°CAssay Description:The human ATIC enzyme was used for the inhibition assay. The assay buffer was flushed with nitrogen to minimize oxidization of cofactor 10-f-THF. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2008
Entry Details Article
PubMed
TargetBifunctional purine biosynthesis protein ATIC(Human)
The Scripps Research Institute

LigandPNGBDBM22582(CHEMBL222602 | 4-{3-methyl-4-[(E)-2-[3-methyl-4-(p...)
Affinity DataIC50: 1.16E+4nMpH: 7.5 T: 2°CAssay Description:The human ATIC enzyme was used for the inhibition assay. The assay buffer was flushed with nitrogen to minimize oxidization of cofactor 10-f-THF. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2008
Entry Details Article
PubMed
TargetBifunctional purine biosynthesis protein ATIC(Human)
The Scripps Research Institute

LigandPNGBDBM22583(yellow 2G | C.I. Food Yellow 5 | CHEMBL222654 | 2,...)
Affinity DataIC50: 2.01E+4nMpH: 7.5 T: 2°CAssay Description:The human ATIC enzyme was used for the inhibition assay. The assay buffer was flushed with nitrogen to minimize oxidization of cofactor 10-f-THF. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2008
Entry Details Article
PubMed
TargetBifunctional purine biosynthesis protein ATIC(Human)
The Scripps Research Institute

LigandPNGBDBM22581(4-chloro-2-[(E)-2-[5-hydroxy-3-methyl-1-(4-sulfoph...)
Affinity DataIC50: 4.16E+4nMpH: 7.5 T: 2°CAssay Description:The human ATIC enzyme was used for the inhibition assay. The assay buffer was flushed with nitrogen to minimize oxidization of cofactor 10-f-THF. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2008
Entry Details Article
PubMed
TargetBifunctional purine biosynthesis protein ATIC(Human)
The Scripps Research Institute

LigandPNGBDBM22578(2-[(E)-2-[5-hydroxy-3-methyl-1-(2-methyl-4-sulfoph...)
Affinity DataKi:  7.10E+3nM ΔG°:  -29.1kJ/mole IC50: 1.16E+4nMpH: 7.5 T: 2°CAssay Description:The human ATIC enzyme was used for the inhibition assay. The assay buffer was flushed with nitrogen to minimize oxidization of cofactor 10-f-THF. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2008
Entry Details Article
PubMed