Compile Data Set for Download or QSAR
Report error Found 35 Enz. Inhib. hit(s) with all data for entry = 5259
TargetCarbonic anhydrase 2(Human)
UniversitÀ Degli Studi Di Firenze

LigandPNGBDBM14722(Sulfonamide, 8 | 1-N-[5-Sulfamoyl-1,3,4-thiadiazol...)
Affinity DataKi:  0.200nM ΔG°:  -54.4kJ/molepH: 7.4 T: 2°CAssay Description:The initial rates of 4-nitrophenylacetate hydrolysis catalysed by different CA isozymes were monitored spectrophotometrically at 400nm with a Cary 3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 4(Bovine)
UniversitÀ Degli Studi Di Firenze

LigandPNGBDBM14722(Sulfonamide, 8 | 1-N-[5-Sulfamoyl-1,3,4-thiadiazol...)
Affinity DataKi:  2nM ΔG°:  -48.8kJ/molepH: 7.4 T: 2°CAssay Description:The initial rates of 4-nitrophenylacetate hydrolysis catalysed by different CA isozymes were monitored spectrophotometrically at 400nm with a Cary 3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
UniversitÀ Degli Studi Di Firenze

LigandPNGBDBM14722(Sulfonamide, 8 | 1-N-[5-Sulfamoyl-1,3,4-thiadiazol...)
Affinity DataKi:  3nM ΔG°:  -47.8kJ/molepH: 7.4 T: 2°CAssay Description:The initial rates of 4-nitrophenylacetate hydrolysis catalysed by different CA isozymes were monitored spectrophotometrically at 400nm with a Cary 3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
UniversitÀ Degli Studi Di Firenze

LigandPNGBDBM85658(EZA4)
Affinity DataKi:  8nM ΔG°:  -45.4kJ/molepH: 7.4 T: 2°CAssay Description:The initial rates of 4-nitrophenylacetate hydrolysis catalysed by different CA isozymes were monitored spectrophotometrically at 400nm with a Cary 3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
UniversitÀ Degli Studi Di Firenze

LigandPNGBDBM10886(BZA1 | CHEMBL73962 | 2-N-benzene-1,3,4-thiadiazole...)
Affinity DataKi:  9nM ΔG°:  -45.2kJ/molepH: 7.4 T: 2°CAssay Description:The initial rates of 4-nitrophenylacetate hydrolysis catalysed by different CA isozymes were monitored spectrophotometrically at 400nm with a Cary 3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
UniversitÀ Degli Studi Di Firenze

LigandPNGBDBM85660(Sulfonamide, 6)
Affinity DataKi:  10nM ΔG°:  -44.9kJ/molepH: 7.4 T: 2°CAssay Description:The initial rates of 4-nitrophenylacetate hydrolysis catalysed by different CA isozymes were monitored spectrophotometrically at 400nm with a Cary 3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
UniversitÀ Degli Studi Di Firenze

LigandPNGBDBM10880(Acetazolamide, AAZ | AZA2 | CHEMBL20 | Acetazolami...)
Affinity DataKi:  12nM ΔG°:  -44.5kJ/molepH: 7.4 T: 2°CAssay Description:The initial rates of 4-nitrophenylacetate hydrolysis catalysed by different CA isozymes were monitored spectrophotometrically at 400nm with a Cary 3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 4(Human)
UniversitÀ Degli Studi Di Firenze

LigandPNGBDBM10886(BZA1 | CHEMBL73962 | 2-N-benzene-1,3,4-thiadiazole...)
Affinity DataKi:  12nM ΔG°:  -44.5kJ/molepH: 7.4 T: 2°CAssay Description:The initial rates of 4-nitrophenylacetate hydrolysis catalysed by different CA isozymes were monitored spectrophotometrically at 400nm with a Cary 3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 4(Human)
UniversitÀ Degli Studi Di Firenze

LigandPNGBDBM85658(EZA4)
Affinity DataKi:  13nM ΔG°:  -44.3kJ/molepH: 7.4 T: 2°CAssay Description:The initial rates of 4-nitrophenylacetate hydrolysis catalysed by different CA isozymes were monitored spectrophotometrically at 400nm with a Cary 3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
UniversitÀ Degli Studi Di Firenze

LigandPNGBDBM50141779(CHEMBL171350 | Sulfonamide, 7 | 2,6-Dimethyl-4-phe...)
Affinity DataKi:  14nM ΔG°:  -44.1kJ/molepH: 7.4 T: 2°CAssay Description:The initial rates of 4-nitrophenylacetate hydrolysis catalysed by different CA isozymes were monitored spectrophotometrically at 400nm with a Cary 3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
UniversitÀ Degli Studi Di Firenze

LigandPNGBDBM10881(CHEMBL288100 | cid_4100 | N-[(2Z)-3-methyl-5-sulfa...)
Affinity DataKi:  14nM ΔG°:  -44.1kJ/molepH: 7.4 T: 2°CAssay Description:The initial rates of 4-nitrophenylacetate hydrolysis catalysed by different CA isozymes were monitored spectrophotometrically at 400nm with a Cary 3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 1(Human)
UniversitÀ Degli Studi Di Firenze

LigandPNGBDBM10886(BZA1 | CHEMBL73962 | 2-N-benzene-1,3,4-thiadiazole...)
Affinity DataKi:  15nM ΔG°:  -43.9kJ/molepH: 7.4 T: 2°CAssay Description:The initial rates of 4-nitrophenylacetate hydrolysis catalysed by different CA isozymes were monitored spectrophotometrically at 400nm with a Cary 3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 13(Human)
UniversitÀ Degli Studi Di Firenze

LigandPNGBDBM10880(Acetazolamide, AAZ | AZA2 | CHEMBL20 | Acetazolami...)
Affinity DataKi:  17nM ΔG°:  -43.6kJ/molepH: 7.4 T: 2°CAssay Description:The initial rates of 4-nitrophenylacetate hydrolysis catalysed by different CA isozymes were monitored spectrophotometrically at 400nm with a Cary 3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 1(Human)
UniversitÀ Degli Studi Di Firenze

LigandPNGBDBM85658(EZA4)
Affinity DataKi:  25nM ΔG°:  -42.7kJ/molepH: 7.4 T: 2°CAssay Description:The initial rates of 4-nitrophenylacetate hydrolysis catalysed by different CA isozymes were monitored spectrophotometrically at 400nm with a Cary 3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 9(Human)
UniversitÀ Degli Studi Di Firenze

LigandPNGBDBM10880(Acetazolamide, AAZ | AZA2 | CHEMBL20 | Acetazolami...)
Affinity DataKi:  25nM ΔG°:  -42.7kJ/molepH: 7.4 T: 2°CAssay Description:The initial rates of 4-nitrophenylacetate hydrolysis catalysed by different CA isozymes were monitored spectrophotometrically at 400nm with a Cary 3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 9(Human)
UniversitÀ Degli Studi Di Firenze

LigandPNGBDBM10881(CHEMBL288100 | cid_4100 | N-[(2Z)-3-methyl-5-sulfa...)
Affinity DataKi:  27nM ΔG°:  -42.5kJ/molepH: 7.4 T: 2°CAssay Description:The initial rates of 4-nitrophenylacetate hydrolysis catalysed by different CA isozymes were monitored spectrophotometrically at 400nm with a Cary 3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 4(Bovine)
UniversitÀ Degli Studi Di Firenze

LigandPNGBDBM50141779(CHEMBL171350 | Sulfonamide, 7 | 2,6-Dimethyl-4-phe...)
Affinity DataKi:  29nM ΔG°:  -42.3kJ/molepH: 7.4 T: 2°CAssay Description:The initial rates of 4-nitrophenylacetate hydrolysis catalysed by different CA isozymes were monitored spectrophotometrically at 400nm with a Cary 3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
UniversitÀ Degli Studi Di Firenze

LigandPNGBDBM85659(DCP5)
Affinity DataKi:  30nM ΔG°:  -42.2kJ/molepH: 7.4 T: 2°CAssay Description:The initial rates of 4-nitrophenylacetate hydrolysis catalysed by different CA isozymes were monitored spectrophotometrically at 400nm with a Cary 3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 9(Human)
UniversitÀ Degli Studi Di Firenze

LigandPNGBDBM85658(EZA4)
Affinity DataKi:  34nM ΔG°:  -41.9kJ/molepH: 7.4 T: 2°CAssay Description:The initial rates of 4-nitrophenylacetate hydrolysis catalysed by different CA isozymes were monitored spectrophotometrically at 400nm with a Cary 3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 5A, mitochondrial(Mouse)
UniversitÀ Degli Studi Di Firenze

LigandPNGBDBM10886(BZA1 | CHEMBL73962 | 2-N-benzene-1,3,4-thiadiazole...)
Affinity DataKi:  36nM ΔG°:  -41.8kJ/molepH: 7.4 T: 2°CAssay Description:The initial rates of 4-nitrophenylacetate hydrolysis catalysed by different CA isozymes were monitored spectrophotometrically at 400nm with a Cary 3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 9(Human)
UniversitÀ Degli Studi Di Firenze

LigandPNGBDBM10886(BZA1 | CHEMBL73962 | 2-N-benzene-1,3,4-thiadiazole...)
Affinity DataKi:  45nM ΔG°:  -41.2kJ/molepH: 7.4 T: 2°CAssay Description:The initial rates of 4-nitrophenylacetate hydrolysis catalysed by different CA isozymes were monitored spectrophotometrically at 400nm with a Cary 3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 5A, mitochondrial(Mouse)
UniversitÀ Degli Studi Di Firenze

LigandPNGBDBM85658(EZA4)
Affinity DataKi:  47nM ΔG°:  -41.1kJ/molepH: 7.4 T: 2°CAssay Description:The initial rates of 4-nitrophenylacetate hydrolysis catalysed by different CA isozymes were monitored spectrophotometrically at 400nm with a Cary 3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 9(Human)
UniversitÀ Degli Studi Di Firenze

LigandPNGBDBM85659(DCP5)
Affinity DataKi:  50nM ΔG°:  -41.0kJ/molepH: 7.4 T: 2°CAssay Description:The initial rates of 4-nitrophenylacetate hydrolysis catalysed by different CA isozymes were monitored spectrophotometrically at 400nm with a Cary 3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 5A, mitochondrial(Mouse)
UniversitÀ Degli Studi Di Firenze

LigandPNGBDBM10880(Acetazolamide, AAZ | AZA2 | CHEMBL20 | Acetazolami...)
Affinity DataKi:  60nM ΔG°:  -40.5kJ/molepH: 7.4 T: 2°CAssay Description:The initial rates of 4-nitrophenylacetate hydrolysis catalysed by different CA isozymes were monitored spectrophotometrically at 400nm with a Cary 3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 5A, mitochondrial(Mouse)
UniversitÀ Degli Studi Di Firenze

LigandPNGBDBM10881(CHEMBL288100 | cid_4100 | N-[(2Z)-3-methyl-5-sulfa...)
Affinity DataKi:  63nM ΔG°:  -40.4kJ/molepH: 7.4 T: 2°CAssay Description:The initial rates of 4-nitrophenylacetate hydrolysis catalysed by different CA isozymes were monitored spectrophotometrically at 400nm with a Cary 3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 4(Human)
UniversitÀ Degli Studi Di Firenze

LigandPNGBDBM85659(DCP5)
Affinity DataKi:  120nM ΔG°:  -38.8kJ/molepH: 7.4 T: 2°CAssay Description:The initial rates of 4-nitrophenylacetate hydrolysis catalysed by different CA isozymes were monitored spectrophotometrically at 400nm with a Cary 3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 4(Bovine)
UniversitÀ Degli Studi Di Firenze

LigandPNGBDBM85660(Sulfonamide, 6)
Affinity DataKi:  170nM ΔG°:  -38.0kJ/molepH: 7.4 T: 2°CAssay Description:The initial rates of 4-nitrophenylacetate hydrolysis catalysed by different CA isozymes were monitored spectrophotometrically at 400nm with a Cary 3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 4(Human)
UniversitÀ Degli Studi Di Firenze

LigandPNGBDBM10880(Acetazolamide, AAZ | AZA2 | CHEMBL20 | Acetazolami...)
Affinity DataKi:  220nM ΔG°:  -37.4kJ/molepH: 7.4 T: 2°CAssay Description:The initial rates of 4-nitrophenylacetate hydrolysis catalysed by different CA isozymes were monitored spectrophotometrically at 400nm with a Cary 3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 4(Human)
UniversitÀ Degli Studi Di Firenze

LigandPNGBDBM10881(CHEMBL288100 | cid_4100 | N-[(2Z)-3-methyl-5-sulfa...)
Affinity DataKi:  240nM ΔG°:  -37.2kJ/molepH: 7.4 T: 2°CAssay Description:The initial rates of 4-nitrophenylacetate hydrolysis catalysed by different CA isozymes were monitored spectrophotometrically at 400nm with a Cary 3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 1(Human)
UniversitÀ Degli Studi Di Firenze

LigandPNGBDBM50141779(CHEMBL171350 | Sulfonamide, 7 | 2,6-Dimethyl-4-phe...)
Affinity DataKi:  250nM ΔG°:  -37.1kJ/molepH: 7.4 T: 2°CAssay Description:The initial rates of 4-nitrophenylacetate hydrolysis catalysed by different CA isozymes were monitored spectrophotometrically at 400nm with a Cary 3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
UniversitÀ Degli Studi Di Firenze

LigandPNGBDBM85659(DCP5)
Affinity DataKi:  350nM ΔG°:  -36.2kJ/molepH: 7.4 T: 2°CAssay Description:The initial rates of 4-nitrophenylacetate hydrolysis catalysed by different CA isozymes were monitored spectrophotometrically at 400nm with a Cary 3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
UniversitÀ Degli Studi Di Firenze

LigandPNGBDBM85660(Sulfonamide, 6)
Affinity DataKi:  400nM ΔG°:  -35.9kJ/molepH: 7.4 T: 2°CAssay Description:The initial rates of 4-nitrophenylacetate hydrolysis catalysed by different CA isozymes were monitored spectrophotometrically at 400nm with a Cary 3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 5A, mitochondrial(Mouse)
UniversitÀ Degli Studi Di Firenze

LigandPNGBDBM85659(DCP5)
Affinity DataKi:  640nM ΔG°:  -34.8kJ/molepH: 7.4 T: 2°CAssay Description:The initial rates of 4-nitrophenylacetate hydrolysis catalysed by different CA isozymes were monitored spectrophotometrically at 400nm with a Cary 3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
UniversitÀ Degli Studi Di Firenze

LigandPNGBDBM10881(CHEMBL288100 | cid_4100 | N-[(2Z)-3-methyl-5-sulfa...)
Affinity DataKi:  780nM ΔG°:  -34.3kJ/molepH: 7.4 T: 2°CAssay Description:The initial rates of 4-nitrophenylacetate hydrolysis catalysed by different CA isozymes were monitored spectrophotometrically at 400nm with a Cary 3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 1(Human)
UniversitÀ Degli Studi Di Firenze

LigandPNGBDBM10880(Acetazolamide, AAZ | AZA2 | CHEMBL20 | Acetazolami...)
Affinity DataKi:  900nM ΔG°:  -33.9kJ/molepH: 7.4 T: 2°CAssay Description:The initial rates of 4-nitrophenylacetate hydrolysis catalysed by different CA isozymes were monitored spectrophotometrically at 400nm with a Cary 3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)