Compile Data Set for Download or QSAR
Report error Found 33 Enz. Inhib. hit(s) with all data for entry = 50015551
TargetB1 bradykinin receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50157515(4'-{(R)-1-[4-chloro-3-(2-cyano-acetylamino)-pyridi...)
Affinity DataIC50: 0.25nMAssay Description:Antagonist activity at bradykinin B1 receptor expressed in CHO cells assessed as inhibition of des-arg10-kallidin-induced increase in cytosolic calci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50157510(N-(4-chloro-2-{(R)-1-[3'-fluoro-2'-(5-methyl-[1,2,...)
Affinity DataIC50: 0.780nMAssay Description:Antagonist activity at bradykinin B1 receptor expressed in CHO cells assessed as inhibition of des-arg10-kallidin-induced increase in cytosolic calci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50157513(3-chloro-4'-{(R)-1-[4-chloro-3-(2-cyano-acetylamin...)
Affinity DataIC50: 0.850nMAssay Description:Antagonist activity at bradykinin B1 receptor expressed in CHO cells assessed as inhibition of des-arg10-kallidin-induced increase in cytosolic calci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50157509(N-(4-chloro-2-{(R)-1-[3'-fluoro-2'-(3-methyl-[1,2,...)
Affinity DataIC50: 0.940nMAssay Description:Antagonist activity at bradykinin B1 receptor expressed in CHO cells assessed as inhibition of des-arg10-kallidin-induced increase in cytosolic calci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50157511(N-(4-chloro-2-{(R)-1-[3'-fluoro-2'-(2-methyl-2H-te...)
Affinity DataIC50: 1.17nMAssay Description:Antagonist activity at bradykinin B1 receptor expressed in CHO cells assessed as inhibition of des-arg10-kallidin-induced increase in cytosolic calci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50157516(4'-{(R)-1-[3-(2-cyano-acetylamino)-4-methyl-pyridi...)
Affinity DataIC50: 1.40nMAssay Description:Antagonist activity at bradykinin B1 receptor expressed in CHO cells assessed as inhibition of des-arg10-kallidin-induced increase in cytosolic calci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50157518(5-chloro-4'-{(R)-1-[4-chloro-3-(2-cyano-acetylamin...)
Affinity DataIC50: 1.5nMAssay Description:Antagonist activity at bradykinin B1 receptor expressed in CHO cells assessed as inhibition of des-arg10-kallidin-induced increase in cytosolic calci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Rabbit)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50157515(4'-{(R)-1-[4-chloro-3-(2-cyano-acetylamino)-pyridi...)
Affinity DataIC50: 2.40nMAssay Description:Activity at rabbit bradykinin B1 receptor assessed by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Rabbit)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50157511(N-(4-chloro-2-{(R)-1-[3'-fluoro-2'-(2-methyl-2H-te...)
Affinity DataIC50: 3.90nMAssay Description:Activity at rabbit bradykinin B1 receptor assessed by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Rabbit)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50157513(3-chloro-4'-{(R)-1-[4-chloro-3-(2-cyano-acetylamin...)
Affinity DataIC50: 7.20nMAssay Description:Activity at rabbit bradykinin B1 receptor assessed by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Rabbit)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50157509(N-(4-chloro-2-{(R)-1-[3'-fluoro-2'-(3-methyl-[1,2,...)
Affinity DataIC50: 12.3nMAssay Description:Activity at rabbit bradykinin B1 receptor assessed by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50157515(4'-{(R)-1-[4-chloro-3-(2-cyano-acetylamino)-pyridi...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]des-arg10, leu9-kallidin from human bradykinin B1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50157511(N-(4-chloro-2-{(R)-1-[3'-fluoro-2'-(2-methyl-2H-te...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]des-arg10, leu9-kallidin from human bradykinin B1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50157509(N-(4-chloro-2-{(R)-1-[3'-fluoro-2'-(3-methyl-[1,2,...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]des-arg10, leu9-kallidin from human bradykinin B1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Rabbit)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50157515(4'-{(R)-1-[4-chloro-3-(2-cyano-acetylamino)-pyridi...)
Affinity DataKi:  0.690nMAssay Description:Binding affinity to rabbit bradykinin B1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50157510(N-(4-chloro-2-{(R)-1-[3'-fluoro-2'-(5-methyl-[1,2,...)
Affinity DataKi:  0.700nMAssay Description:Displacement of [3H]des-arg10, leu9-kallidin from human bradykinin B1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50157513(3-chloro-4'-{(R)-1-[4-chloro-3-(2-cyano-acetylamin...)
Affinity DataKi:  0.700nMAssay Description:Displacement of [3H]des-arg10, leu9-kallidin from human bradykinin B1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50157518(5-chloro-4'-{(R)-1-[4-chloro-3-(2-cyano-acetylamin...)
Affinity DataKi:  0.800nMAssay Description:Displacement of [3H]des-arg10, leu9-kallidin from human bradykinin B1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50157517(N-{4-chloro-2-[(R)-1-(3'-fluoro-2'-trifluoromethyl...)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]des-arg10, leu9-kallidin from human bradykinin B1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Rabbit)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50157513(3-chloro-4'-{(R)-1-[4-chloro-3-(2-cyano-acetylamin...)
Affinity DataKi:  1.10nMAssay Description:Binding affinity to rabbit bradykinin B1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50157516(4'-{(R)-1-[3-(2-cyano-acetylamino)-4-methyl-pyridi...)
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H]des-arg10, leu9-kallidin from human bradykinin B1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50157512(N-{4-chloro-2-[(R)-1-(2'-cyano-3'-fluoro-biphenyl-...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]des-arg10, leu9-kallidin from human bradykinin B1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Rabbit)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50157509(N-(4-chloro-2-{(R)-1-[3'-fluoro-2'-(3-methyl-[1,2,...)
Affinity DataKi:  2.70nMAssay Description:Binding affinity to rabbit bradykinin B1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Rabbit)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50157511(N-(4-chloro-2-{(R)-1-[3'-fluoro-2'-(2-methyl-2H-te...)
Affinity DataKi:  3nMAssay Description:Binding affinity to rabbit bradykinin B1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50157514(N-(4-chloro-2-{(R)-1-[3'-fluoro-2'-(1-methyl-1H-te...)
Affinity DataKi:  6nMAssay Description:Displacement of [3H]des-arg10, leu9-kallidin from human bradykinin B1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50157514(N-(4-chloro-2-{(R)-1-[3'-fluoro-2'-(1-methyl-1H-te...)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]des-arg10 kallidin from rat bradykinin B1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50157515(4'-{(R)-1-[4-chloro-3-(2-cyano-acetylamino)-pyridi...)
Affinity DataKi:  35.3nMAssay Description:Displacement of [3H]des-arg10 kallidin from rat bradykinin B1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50157513(3-chloro-4'-{(R)-1-[4-chloro-3-(2-cyano-acetylamin...)
Affinity DataKi:  35.7nMAssay Description:Displacement of [3H]des-arg10 kallidin from rat bradykinin B1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Rabbit)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50157514(N-(4-chloro-2-{(R)-1-[3'-fluoro-2'-(1-methyl-1H-te...)
Affinity DataKi:  41.5nMAssay Description:Binding affinity to rabbit bradykinin B1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50157509(N-(4-chloro-2-{(R)-1-[3'-fluoro-2'-(3-methyl-[1,2,...)
Affinity DataKi:  81nMAssay Description:Displacement of [3H]des-arg10 kallidin from rat bradykinin B1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50157511(N-(4-chloro-2-{(R)-1-[3'-fluoro-2'-(2-methyl-2H-te...)
Affinity DataKi:  119nMAssay Description:Displacement of [3H]des-arg10 kallidin from rat bradykinin B1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50157519(4'-[(3-pentanoylamino-pyridin-2-ylamino)-methyl]-b...)
Affinity DataKi:  200nMAssay Description:Displacement of [3H]des-arg10, leu9-kallidin from human bradykinin B1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetB2 bradykinin receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50157516(4'-{(R)-1-[3-(2-cyano-acetylamino)-4-methyl-pyridi...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]bradykinin from human bradykinin B2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed