Compile Data Set for Download or QSAR
Report error Found 6 Enz. Inhib. hit(s) with all data for entry = 50015634
TargetDihydrofolate reductase(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50158569(2-S-[5-[2,4-diaminopteridin-6-yl)methyamino]-2,3-d...)
Affinity DataKi:  0.0340nMAssay Description:Inhibition of human DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50158570(2-R,S-[5-[(2,4-diaminopteridin-6-yl)methylamino]-2...)
Affinity DataKi:  0.0770nMAssay Description:Inhibition of human DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50158571(2-S-[5-[N-(2,4--diaminopteridin-6-yl)methyl)-N-met...)
Affinity DataKi:  2.10nMAssay Description:Inhibition of human DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReduced folate transporter(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50158569(2-S-[5-[2,4-diaminopteridin-6-yl)methyamino]-2,3-d...)
Affinity DataKi:  280nMAssay Description:Inhibition of RFC-mediated [3H]MTX influx into human CCRF-CEM cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReduced folate transporter(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50158570(2-R,S-[5-[(2,4-diaminopteridin-6-yl)methylamino]-2...)
Affinity DataKi:  530nMAssay Description:Inhibition of RFC-mediated [3H]MTX influx into human CCRF-CEM cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReduced folate transporter(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50158571(2-S-[5-[N-(2,4--diaminopteridin-6-yl)methyl)-N-met...)
Affinity DataKi:  1.10E+3nMAssay Description:Inhibition of RFC-mediated [3H]MTX influx into human CCRF-CEM cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed