Compile Data Set for Download or QSAR
Report error Found 17 Enz. Inhib. hit(s) with all data for entry = 1421
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Vernalis (R&D)

LigandPNGBDBM11439(4-({5-[(4-aminocyclohexyl)amino]-3-bromopyrazolo[1...)
Affinity DataIC50: 2nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2006
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Vernalis (R&D)

LigandPNGBDBM11429(4-({5-[(4-aminocyclohexyl)amino]-3-cyclopentylpyra...)
Affinity DataIC50: 4nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2006
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Vernalis (R&D)

LigandPNGBDBM11430(4-({5-[(4-aminocyclohexyl)amino]-3-cyanopyrazolo[1...)
Affinity DataIC50: 7nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2006
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Vernalis (R&D)

LigandPNGBDBM11431(4-({5-[(4-aminocyclohexyl)amino]-3-chloropyrazolo[...)
Affinity DataIC50: 8nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2006
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Vernalis (R&D)

LigandPNGBDBM11432(4-({5-[(4-aminocyclohexyl)amino]-3-bromopyrazolo[1...)
Affinity DataIC50: 10nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2006
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Vernalis (R&D)

LigandPNGBDBM11440(5-N-(4-aminocyclohexyl)-3-chloro-7-N-[4-(thiophene...)
Affinity DataIC50: 11nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2006
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Vernalis (R&D)

LigandPNGBDBM11441(5-N-(4-aminocyclohexyl)-7-N-[4-(benzenesulfonyl)ph...)
Affinity DataIC50: 16nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2006
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Vernalis (R&D)

LigandPNGBDBM11435(4-({5-[(4-aminocyclohexyl)oxy]-3-(propan-2-yl)pyra...)
Affinity DataIC50: 17nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2006
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Vernalis (R&D)

LigandPNGBDBM11428(4-({5-[(4-aminocyclohexyl)amino]-3-(propan-2-yl)py...)
Affinity DataIC50: 59nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2006
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Vernalis (R&D)

LigandPNGBDBM11433(4-[(5-{[4-(ethylamino)cyclohexyl]amino}-3-(propan-...)
Affinity DataIC50: 61nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2006
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Vernalis (R&D)

LigandPNGBDBM11434(4-[(5-{[4-(diethylamino)cyclohexyl]amino}-3-(propa...)
Affinity DataIC50: 92nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2006
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Vernalis (R&D)

LigandPNGBDBM11443(5-chloro-N-(4-methanesulfonylphenyl)-3-(propan-2-y...)
Affinity DataIC50: 230nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2006
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Vernalis (R&D)

LigandPNGBDBM11437(N,N-dimethyl-4-{[5-(2-methylpropoxy)-3-(propan-2-y...)
Affinity DataIC50: 1.20E+3nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2006
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Vernalis (R&D)

LigandPNGBDBM11438(N-(4-methanesulfonylphenyl)-5-(2-methylpropoxy)-3-...)
Affinity DataIC50: 1.20E+3nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2006
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Vernalis (R&D)

LigandPNGBDBM11444(5-(3-bromophenyl)-N-(pyridin-4-ylmethyl)pyrazolo[1...)
Affinity DataIC50: 1.80E+3nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2006
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Vernalis (R&D)

LigandPNGBDBM11442(5-chloro-N-(4-methanesulfonylphenyl)pyrazolo[1,5-a...)
Affinity DataIC50: 2.00E+3nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2006
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Vernalis (R&D)

LigandPNGBDBM11436(4-({5-[(3-aminocyclohexyl)amino]-3-(propan-2-yl)py...)
Affinity DataIC50: 2.10E+3nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2006
Entry Details Article
PubMed