Compile Data Set for Download or QSAR
Report error Found 26 Enz. Inhib. hit(s) with all data for entry = 50036118
TargetDihydrofolate reductase(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM18050(MTX | cid_126941 | Methotrexate | 2-[(4-{[(2,4-dia...)
Affinity DataIC50: 2.70nMAssay Description:In vitro inhibition of human dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetThymidylate synthase(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50005862(2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylme...)
Affinity DataIC50: 68nMAssay Description:In vitro inhibition of human thymidylate synthase (TS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50005863(CHEMBL39175 | 2-{4-[(2-Amino-4-oxo-3,4-dihydro-pyr...)
Affinity DataIC50: 400nMAssay Description:In vitro inhibition of human dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50005866(CHEMBL294973 | 2-{4-[(2-Amino-4-oxo-3,4-dihydro-py...)
Affinity DataIC50: 1.30E+3nMAssay Description:In vitro inhibition of human dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50005867(CHEMBL40850 | 2-{4-[(2-Amino-4-oxo-3,4-dihydro-pyr...)
Affinity DataIC50: 4.70E+3nMAssay Description:In vitro inhibition of human dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50005865(CHEMBL417696 | 2-{4-[(2-Amino-4-oxo-3,4,5,6,7,8-he...)
Affinity DataIC50: 1.20E+4nMAssay Description:In vitro inhibition of human dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetThymidylate synthase(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50005863(CHEMBL39175 | 2-{4-[(2-Amino-4-oxo-3,4-dihydro-pyr...)
Affinity DataIC50: 5.50E+4nMAssay Description:In vitro inhibition of human thymidylate synthase (TS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetThymidylate synthase(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50005866(CHEMBL294973 | 2-{4-[(2-Amino-4-oxo-3,4-dihydro-py...)
Affinity DataIC50: 1.00E+5nMAssay Description:In vitro inhibition of human thymidylate synthase (TS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50005868(CHEMBL38902 | 2-{4-[(2-Amino-4-oxo-3,4,5,6,7,8-hex...)
Affinity DataIC50: 2.20E+5nMAssay Description:In vitro inhibition of human dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetThymidylate synthase(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50005867(CHEMBL40850 | 2-{4-[(2-Amino-4-oxo-3,4-dihydro-pyr...)
Affinity DataIC50: 3.00E+5nMAssay Description:In vitro inhibition of human thymidylate synthase (TS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50005860(CHEMBL41459 | 2-{4-[(2-Amino-4-oxo-3,4,5,6,7,8-hex...)
Affinity DataIC50: 9.50E+5nMAssay Description:In vitro inhibition of human dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetThymidylate synthase(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50005860(CHEMBL41459 | 2-{4-[(2-Amino-4-oxo-3,4,5,6,7,8-hex...)
Affinity DataIC50: 5.00E+6nMAssay Description:In vitro inhibition of human thymidylate synthase (TS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetThymidylate synthase(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50005868(CHEMBL38902 | 2-{4-[(2-Amino-4-oxo-3,4,5,6,7,8-hex...)
Affinity DataIC50: 4.20E+6nMAssay Description:In vitro inhibition of human thymidylate synthase (TS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetThymidylate synthase(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50005865(CHEMBL417696 | 2-{4-[(2-Amino-4-oxo-3,4,5,6,7,8-he...)
Affinity DataIC50: 2.10E+6nMAssay Description:In vitro inhibition of human thymidylate synthase (TS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetFolylpolyglutamate synthase, mitochondrial(Mouse)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50002471(CHEMBL289923 | 5-Amino-2-{4-[(2-amino-4-oxo-2,3,4,...)
Affinity DataKi:  30nMAssay Description:In vitro inhibition of mouse liver Folyl-polyglutamate synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Mouse)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50005868(CHEMBL38902 | 2-{4-[(2-Amino-4-oxo-3,4,5,6,7,8-hex...)
Affinity DataKi:  47nMAssay Description:In vitro inhibition of glycinamide ribonucleotide formyltransferase from L1210 murine leukemia cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Mouse)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50024475(2-{4-[(2-Amino-4-oxo-1,4,5,6,7,8-hexahydro-quinazo...)
Affinity DataKi:  65nMAssay Description:In vitro inhibition of mouse GAR transformylaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Mouse)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50005865(CHEMBL417696 | 2-{4-[(2-Amino-4-oxo-3,4,5,6,7,8-he...)
Affinity DataKi:  190nMAssay Description:In vitro inhibition of glycinamide ribonucleotide formyltransferase from L1210 murine leukemia cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetFolylpolyglutamate synthase, mitochondrial(Mouse)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50005868(CHEMBL38902 | 2-{4-[(2-Amino-4-oxo-3,4,5,6,7,8-hex...)
Affinity DataKi:  3.20E+3nMAssay Description:In vitro inhibition of mouse liver Folyl-polyglutamate synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Mouse)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50002471(CHEMBL289923 | 5-Amino-2-{4-[(2-amino-4-oxo-2,3,4,...)
Affinity DataKi:  3.70E+3nMAssay Description:In vitro inhibition of glycinamide ribonucleotide formyltransferase from L1210 murine leukemia cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetFolylpolyglutamate synthase, mitochondrial(Mouse)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50005859(CHEMBL35921 | 5-Amino-2-{4-[(2,4-diamino-pyrido[3,...)
Affinity DataKi:  5.70E+3nMAssay Description:In vitro inhibition of mouse liver Folyl-polyglutamate synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetFolylpolyglutamate synthase, mitochondrial(Mouse)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50005867(CHEMBL40850 | 2-{4-[(2-Amino-4-oxo-3,4-dihydro-pyr...)
Affinity DataKi:  9.00E+3nMAssay Description:In vitro inhibition of mouse liver Folyl-polyglutamate synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetFolylpolyglutamate synthase, mitochondrial(Mouse)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50005865(CHEMBL417696 | 2-{4-[(2-Amino-4-oxo-3,4,5,6,7,8-he...)
Affinity DataKi:  2.20E+4nMAssay Description:In vitro inhibition of mouse liver Folyl-polyglutamate synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetFolylpolyglutamate synthase, mitochondrial(Mouse)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50005860(CHEMBL41459 | 2-{4-[(2-Amino-4-oxo-3,4,5,6,7,8-hex...)
Affinity DataKi:  1.15E+5nMAssay Description:In vitro inhibition of mouse liver Folyl-polyglutamate synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetFolylpolyglutamate synthase, mitochondrial(Mouse)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50005863(CHEMBL39175 | 2-{4-[(2-Amino-4-oxo-3,4-dihydro-pyr...)
Affinity DataKi:  5.70E+5nMAssay Description:In vitro inhibition of mouse liver Folyl-polyglutamate synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetFolylpolyglutamate synthase, mitochondrial(Mouse)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50005866(CHEMBL294973 | 2-{4-[(2-Amino-4-oxo-3,4-dihydro-py...)
Affinity DataKi:  2.00E+6nMAssay Description:In vitro inhibition of mouse liver Folyl-polyglutamate synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed