Compile Data Set for Download or QSAR
Report error Found 12 Enz. Inhib. hit(s) with all data for entry = 50016625
TargetBeta-secretase 1/2(Human)
University of ZüRich

Curated by ChEMBL
LigandPNGBDBM50171338(5-[3-(3,5-Bis-trifluoromethyl-phenyl)-ureido]-2-di...)
Affinity DataEC50:  2.70E+4nMAssay Description:Beta-secretase inhibitory activity as inhibition of secreted alkaline phosphatase in HEK293 cells expressing SEAP-APP fusion proteinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1/2(Human)
University of ZüRich

Curated by ChEMBL
LigandPNGBDBM50171337(5-[3-(3-Chloro-phenyl)-ureido]-2-dimethylamino-N-(...)
Affinity DataEC50:  23nMAssay Description:Beta-secretase inhibitory activity as inhibition of secreted alkaline phosphatase in HEK293 cells expressing SEAP-APP fusion proteinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1/2(Human)
University of ZüRich

Curated by ChEMBL
LigandPNGBDBM50171339(CHEMBL190346 | cid_11198061 | 1-(3-Acetyl-phenyl)-...)
Affinity DataEC50:  11nMAssay Description:Beta-secretase inhibitory activity as inhibition of secreted alkaline phosphatase in HEK293 cells expressing SEAP-APP fusion proteinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1/2(Human)
University of ZüRich

Curated by ChEMBL
LigandPNGBDBM50171340(5-[3-(3,5-Bis-trifluoromethyl-phenyl)-ureido]-2-di...)
Affinity DataEC50:  3.5nMAssay Description:Beta-secretase inhibitory activity as inhibition of secreted alkaline phosphatase in HEK293 cells expressing SEAP-APP fusion proteinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
University of ZüRich

Curated by ChEMBL
LigandPNGBDBM50171339(CHEMBL190346 | cid_11198061 | 1-(3-Acetyl-phenyl)-...)
Affinity DataIC50: 25nMAssay Description:Inhibitory concentration against beta-site APP cleaving enzyme (BACE-1) by fluorescence resonance energy transfer assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
University of ZüRich

Curated by ChEMBL
LigandPNGBDBM50171340(5-[3-(3,5-Bis-trifluoromethyl-phenyl)-ureido]-2-di...)
Affinity DataIC50: 58nMAssay Description:Inhibitory concentration against beta-site APP cleaving enzyme (BACE-1) by fluorescence resonance energy transfer assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
University of ZüRich

Curated by ChEMBL
LigandPNGBDBM50171337(5-[3-(3-Chloro-phenyl)-ureido]-2-dimethylamino-N-(...)
Affinity DataIC50: 97nMAssay Description:Inhibitory concentration against beta-site APP cleaving enzyme (BACE-1) by fluorescence resonance energy transfer assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
University of ZüRich

Curated by ChEMBL
LigandPNGBDBM50171338(5-[3-(3,5-Bis-trifluoromethyl-phenyl)-ureido]-2-di...)
Affinity DataIC50: 2.84E+5nMAssay Description:Inhibitory concentration against beta-site APP cleaving enzyme (BACE-1) by fluorescence resonance energy transfer assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
University of ZüRich

Curated by ChEMBL
LigandPNGBDBM50171340(5-[3-(3,5-Bis-trifluoromethyl-phenyl)-ureido]-2-di...)
Affinity DataKi:  8.10E+3nMAssay Description:Predicted binding affinity for beta secretase by linear interaction energy continuum electrostaticsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
University of ZüRich

Curated by ChEMBL
LigandPNGBDBM50171338(5-[3-(3,5-Bis-trifluoromethyl-phenyl)-ureido]-2-di...)
Affinity DataKi:  9.40E+3nMAssay Description:Predicted binding affinity for beta secretase by linear interaction energy continuum electrostaticsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
University of ZüRich

Curated by ChEMBL
LigandPNGBDBM50171337(5-[3-(3-Chloro-phenyl)-ureido]-2-dimethylamino-N-(...)
Affinity DataKi:  9.80E+3nMAssay Description:Predicted binding affinity for beta secretase by linear interaction energy continuum electrostaticsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
University of ZüRich

Curated by ChEMBL
LigandPNGBDBM50171339(CHEMBL190346 | cid_11198061 | 1-(3-Acetyl-phenyl)-...)
Affinity DataKi:  2.88E+4nMAssay Description:Predicted binding affinity for beta secretase by linear interaction energy continuum electrostaticsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed