Compile Data Set for Download or QSAR
Report error Found 37 Enz. Inhib. hit(s) with all data for entry = 50016771
TargetCathepsin K(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50240981(4'-piperazin-1-yl-biphenyl-4-carboxylic acid [1-(c...)
Affinity DataIC50: 0.400nMAssay Description:Inhibitory activity against cathepsin K using humanized rabbit enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin K(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM19854(N-{1-[(cyanomethyl)carbamoyl]cyclohexyl}-4-[2-(4-m...)
Affinity DataIC50: 0.600nMAssay Description:Inhibitory activity against cathepsin K using humanized rabbit enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin K(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50173405((S)-2-[1-(4-Bromo-phenyl)-2,2,2-trifluoro-ethylami...)
Affinity DataIC50: 0.900nMAssay Description:Inhibitory activity against cathepsin K from humanized rabbit enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin K(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50150528((S)-4-Methyl-2-[4-(4-piperazin-1-yl-phenyl)-thioph...)
Affinity DataIC50: 1nMAssay Description:Inhibitory activity against cathepsin K using humanized rabbit enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin K(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50173405((S)-2-[1-(4-Bromo-phenyl)-2,2,2-trifluoro-ethylami...)
Affinity DataIC50: 1.30nMAssay Description:Inhibitory activity against cathepsin K using humanized rabbit enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin K(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50173404((S)-2-[1-(4-Bromo-phenyl)-2,2,3,3,3-pentafluoro-pr...)
Affinity DataIC50: 2.40nMAssay Description:Inhibitory activity against cathepsin K using humanized rabbit enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin K(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50173400((S)-2-{[(4-Bromo-phenyl)-(4-methanesulfonyl-phenyl...)
Affinity DataIC50: 2.5nMAssay Description:Inhibitory activity against cathepsin K using humanized rabbit enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin K(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50173403(4-Methyl-2-[2,2,2-trifluoro-1-(4'-piperazin-1-yl-b...)
Affinity DataIC50: 4.60nMAssay Description:Inhibitory activity against cathepsin K using humanized rabbit enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin K(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50173401(1-[2,2,2-Trifluoro-1-(4'-piperazin-1-yl-biphenyl-4...)
Affinity DataIC50: 5nMAssay Description:Inhibitory activity against cathepsin K using humanized rabbit enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin K(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM19856((2R)-N-(cyanomethyl)-4-methyl-2-{3-[4-(piperazin-1...)
Affinity DataIC50: 11nMAssay Description:Inhibitory activity against cathepsin K using humanized rabbit enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin K(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50173408((S)-2-{[(4-Bromo-phenyl)-cyano-methyl]-amino}-4-me...)
Affinity DataIC50: 30nMAssay Description:Inhibitory activity against cathepsin K using humanized rabbit enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50173405((S)-2-[1-(4-Bromo-phenyl)-2,2,2-trifluoro-ethylami...)
Affinity DataIC50: 34nMAssay Description:Inhibitory activity against cathepsin L from humanMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM19518(CHEMBL195454 | (2S)-N-(cyanomethyl)-4-methyl-2-{[(...)
Affinity DataIC50: 47nMAssay Description:Inhibitory activity against cathepsin L from humanMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50173403(4-Methyl-2-[2,2,2-trifluoro-1-(4'-piperazin-1-yl-b...)
Affinity DataIC50: 68nMAssay Description:Inhibitory activity against cathepsin L from humanMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50150528((S)-4-Methyl-2-[4-(4-piperazin-1-yl-phenyl)-thioph...)
Affinity DataIC50: 102nMAssay Description:Inhibitory activity against cathepsin S from humanMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50173405((S)-2-[1-(4-Bromo-phenyl)-2,2,2-trifluoro-ethylami...)
Affinity DataIC50: 121nMAssay Description:Inhibitory activity against cathepsin S from humanMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin B(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50150528((S)-4-Methyl-2-[4-(4-piperazin-1-yl-phenyl)-thioph...)
Affinity DataIC50: 123nMAssay Description:Inhibitory activity against cathepsin B from humanMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50150528((S)-4-Methyl-2-[4-(4-piperazin-1-yl-phenyl)-thioph...)
Affinity DataIC50: 352nMAssay Description:Inhibitory activity against cathepsin L from humanMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM19518(CHEMBL195454 | (2S)-N-(cyanomethyl)-4-methyl-2-{[(...)
Affinity DataIC50: 451nMAssay Description:Inhibitory activity against cathepsin S from humanMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin B(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50240981(4'-piperazin-1-yl-biphenyl-4-carboxylic acid [1-(c...)
Affinity DataIC50: 614nMAssay Description:Inhibitory activity against cathepsin B from humanMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin K(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50173402((S)-2-(4-Bromo-benzylamino)-4-methyl-pentanoic aci...)
Affinity DataIC50: 802nMAssay Description:Inhibitory activity against cathepsin K using humanized rabbit enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50173403(4-Methyl-2-[2,2,2-trifluoro-1-(4'-piperazin-1-yl-b...)
Affinity DataIC50: 902nMAssay Description:Inhibitory activity against cathepsin S from humanMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin K(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50173406((S)-2-[1-(4-Bromo-phenyl)-ethylamino]-4-methyl-pen...)
Affinity DataIC50: 988nMAssay Description:Inhibitory activity against cathepsin K using humanized rabbit enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin B(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM19854(N-{1-[(cyanomethyl)carbamoyl]cyclohexyl}-4-[2-(4-m...)
Affinity DataIC50: 1.05E+3nMAssay Description:Inhibitory activity against cathepsin B from humanMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin B(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM19518(CHEMBL195454 | (2S)-N-(cyanomethyl)-4-methyl-2-{[(...)
Affinity DataIC50: 1.11E+3nMAssay Description:Inhibitory activity against cathepsin B from humanMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM19856((2R)-N-(cyanomethyl)-4-methyl-2-{3-[4-(piperazin-1...)
Affinity DataIC50: 2.01E+3nMAssay Description:Inhibitory activity against cathepsin S from humanMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50240981(4'-piperazin-1-yl-biphenyl-4-carboxylic acid [1-(c...)
Affinity DataIC50: 2.27E+3nMAssay Description:Inhibitory activity against cathepsin L from humanMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin B(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50173405((S)-2-[1-(4-Bromo-phenyl)-2,2,2-trifluoro-ethylami...)
Affinity DataIC50: 3.35E+3nMAssay Description:Inhibitory activity against cathepsin B from humanMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM19856((2R)-N-(cyanomethyl)-4-methyl-2-{3-[4-(piperazin-1...)
Affinity DataIC50: 3.73E+3nMAssay Description:Inhibitory activity against cathepsin L from humanMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM19854(N-{1-[(cyanomethyl)carbamoyl]cyclohexyl}-4-[2-(4-m...)
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibitory activity against cathepsin L from humanMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin B(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM19856((2R)-N-(cyanomethyl)-4-methyl-2-{3-[4-(piperazin-1...)
Affinity DataIC50: 3.95E+3nMAssay Description:Inhibitory activity against cathepsin B from humanMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin B(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50173403(4-Methyl-2-[2,2,2-trifluoro-1-(4'-piperazin-1-yl-b...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibitory activity against cathepsin B from humanMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50173401(1-[2,2,2-Trifluoro-1-(4'-piperazin-1-yl-biphenyl-4...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibitory activity against cathepsin L from humanMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50173401(1-[2,2,2-Trifluoro-1-(4'-piperazin-1-yl-biphenyl-4...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibitory activity against cathepsin S from humanMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50240981(4'-piperazin-1-yl-biphenyl-4-carboxylic acid [1-(c...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibitory activity against cathepsin S from humanMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM19854(N-{1-[(cyanomethyl)carbamoyl]cyclohexyl}-4-[2-(4-m...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibitory activity against cathepsin S from humanMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin B(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50173401(1-[2,2,2-Trifluoro-1-(4'-piperazin-1-yl-biphenyl-4...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibitory activity against cathepsin B from humanMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed