Compile Data Set for Download or QSAR
Report error Found 35 Enz. Inhib. hit(s) with all data for entry = 1694
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Human)
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13462(3-{3-[(3S)-3-(methylcarbamoyl)-7-(sulfoamino)-1,2,...)
Affinity DataIC50: 2.50E+3nMAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2007
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Human)
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13461(N-[(3S)-3-(methylcarbamoyl)-2-{3-[3-(sulfoamino)ph...)
Affinity DataIC50: 4.80E+3nMAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2007
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Human)
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13452(N-[(3S)-2-[(tert-butoxy)carbonyl]-3-(3-methyl-1,2,...)
Affinity DataIC50: 8.23E+3nMAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2007
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Human)
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13451(N-[(3S)-2-[(tert-butoxy)carbonyl]-3-[(2-methylprop...)
Affinity DataIC50: 1.67E+4nMAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2007
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Human)
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13450(N-[(3S)-2-[(tert-butoxy)carbonyl]-3-(methoxycarbon...)
Affinity DataIC50: 1.90E+4nMAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2007
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Human)
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13433(N-[(3S)-2-[(tert-butoxy)carbonyl]-3-(methylcarbamo...)
Affinity DataKi:  2.40E+4nM ΔG°:  -26.1kJ/molepH: 7.0 T: 2°CAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2007
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Human)
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13446(ammonium N-[(3S)-2-[(2E)-3-(1-benzofuran-3-yl)prop...)
Affinity DataIC50: 2.49E+4nMpH: 7.0 T: 2°CAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2007
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Human)
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13464(N-(3-{3-oxo-3-[7-(sulfoamino)-1,2,3,4-tetrahydrois...)
Affinity DataIC50: 2.60E+4nMAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2007
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Human)
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13463(N-{3-[2-({[3-(sulfoamino)phenyl]methyl}carbamoyl)e...)
Affinity DataIC50: 3.35E+4nMAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Human)
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13445(ammonium N-[(3S)-2-[3-(1-benzofuran-3-yl)propanoyl...)
Affinity DataIC50: 3.67E+4nMpH: 7.0 T: 2°CAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2007
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Human)
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13444(ammonium N-[(3S)-2-[(benzyloxy)carbonyl]-3-(methyl...)
Affinity DataIC50: 3.70E+4nMpH: 7.0 T: 2°CAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2007
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Human)
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13431(N-{4-[(2S)-2-{[(tert-butoxy)carbonyl]amino}-2-(met...)
Affinity DataIC50: 3.96E+4nMpH: 7.0 T: 2°CAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2007
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Human)
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13433(N-[(3S)-2-[(tert-butoxy)carbonyl]-3-(methylcarbamo...)
Affinity DataIC50: 4.25E+4nMpH: 7.0 T: 2°CAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2007
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Human)
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13449(N-[(3S)-2-[(tert-butoxy)carbonyl]-3-[(2-phenylethy...)
Affinity DataIC50: 5.14E+4nMAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2007
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Human)
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13443(ammonium N-[(3S)-3-(methylcarbamoyl)-2-(3-phenylpr...)
Affinity DataIC50: 6.44E+4nMpH: 7.0 T: 2°CAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2007
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Human)
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13460(N-[(3S)-2-[3-(3-hydroxyphenyl)propanoyl]-3-(methyl...)
Affinity DataIC50: 8.21E+4nMAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2007
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Human)
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13442(ammonium N-[(3S)-3-(methylcarbamoyl)-2-(3-phenoxyp...)
Affinity DataIC50: 8.36E+4nMpH: 7.0 T: 2°CAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2007
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Human)
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13459(N-[(3S)-2-{2-[3-hydroxy-2-(methoxycarbonyl)phenoxy...)
Affinity DataIC50: 9.34E+4nMAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2007
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Human)
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13441(ammonium N-[(3S)-3-(methylcarbamoyl)-2-(2-phenoxya...)
Affinity DataIC50: 9.53E+4nMpH: 7.0 T: 2°CAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2007
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Human)
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13458(N-[(3S)-2-[3-(3-chlorophenyl)propanoyl]-3-(methylc...)
Affinity DataIC50: 1.01E+5nMAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2007
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Human)
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13448(N-[(3S)-3-(benzylcarbamoyl)-2-[(tert-butoxy)carbon...)
Affinity DataIC50: 1.20E+5nMAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2007
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Human)
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13440(ammonium N-[(3R)-2-[(tert-butoxy)carbonyl]-3-(meth...)
Affinity DataIC50: 1.35E+5nMpH: 7.0 T: 2°CAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2007
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Human)
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13457(N-[(3S)-3-(methylcarbamoyl)-2-{3-[3-(trifluorometh...)
Affinity DataIC50: 1.46E+5nMAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2007
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Human)
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13439(ammonium N-[(3S)-3-(methylcarbamoyl)-2-(5-phenylpe...)
Affinity DataIC50: 1.48E+5nMpH: 7.0 T: 2°CAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2007
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Human)
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13438(ammonium N-[(3S)-2-(3-carboxypropanoyl)-3-(methylc...)
Affinity DataIC50: 1.54E+5nMpH: 7.0 T: 2°CAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2007
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Human)
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13437(ammonium N-[(3S)-2-(benzylcarbamoyl)-3-(methylcarb...)
Affinity DataIC50: 1.64E+5nMpH: 7.0 T: 2°CAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2007
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Human)
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13456(N-[(3S)-2-{3-[3-methanesulfonamido-5-(trifluoromet...)
Affinity DataIC50: 1.84E+5nMAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2007
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Human)
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13455(N-[(3S)-3-(methylcarbamoyl)-2-[3-(4-methylphenyl)p...)
Affinity DataIC50: 1.98E+5nMAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2007
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Human)
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13454(N-[(3S)-3-(methylcarbamoyl)-2-{3-[4-(trifluorometh...)
Affinity DataIC50: 2.25E+5nMAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2007
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Human)
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13453(N-[(3S)-2-[3-(4-methoxyphenyl)propanoyl]-3-(methyl...)
Affinity DataIC50: 2.42E+5nMAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2007
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Human)
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13436(ammonium N-[(3S)-3-(methylcarbamoyl)-2-(4-phenylbu...)
Affinity DataIC50: 2.71E+5nMpH: 7.0 T: 2°CAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2007
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Human)
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13435(ammonium N-[(3S)-2-benzoyl-3-(methylcarbamoyl)-1,2...)
Affinity DataIC50: 2.86E+5nMpH: 7.0 T: 2°CAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2007
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Human)
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13447(N-[(3S)-2-[(tert-butoxy)carbonyl]-3-(hydroxymethyl...)
Affinity DataIC50: 5.00E+5nMpH: 7.0 T: 2°CAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2007
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Human)
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13529(N-(1-methyl-3-phenyl-1H-pyrazol-5-yl)sulfamic acid...)
Affinity DataKi: >5.00E+5nMAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2007
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Human)
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13434(ammonium N-[(3S)-2-{[(2S)-1-(tert-butoxy)-1-oxo-3-...)
Affinity DataIC50: 5.00E+5nMpH: 7.0 T: 2°CAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/29/2007
Entry Details Article
PubMed