Compile Data Set for Download or QSAR
Report error Found 14 Enz. Inhib. hit(s) with all data for entry = 1740
TargetTyrosine-protein phosphatase non-receptor type 2 [V121L](Human)
Merck Frosst Center For Therapeutic Research

LigandPNGBDBM13814(({4-[(4E)-2-(1H-1,2,3-benzotriazol-1-yl)-2-[4-(met...)
Affinity DataIC50: 24nMpH: 6.3 T: 2°CAssay Description:Hydrolysis of substrate FDP was monitored continuously on a Cytofluor microplate reader with excitation and emission wavelengths set at 440 and 515 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2007
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [V113L,M114V](Human)
Merck Frosst Center For Therapeutic Research

LigandPNGBDBM13814(({4-[(4E)-2-(1H-1,2,3-benzotriazol-1-yl)-2-[4-(met...)
Affinity DataIC50: 29nMpH: 6.3 T: 2°CAssay Description:Hydrolysis of substrate FDP was monitored continuously on a Cytofluor microplate reader with excitation and emission wavelengths set at 440 and 515 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein phosphatase non-receptor type 1 [G117E](Human)
Merck Frosst Center For Therapeutic Research

LigandPNGBDBM13814(({4-[(4E)-2-(1H-1,2,3-benzotriazol-1-yl)-2-[4-(met...)
Affinity DataIC50: 32nMpH: 6.3 T: 2°CAssay Description:Hydrolysis of substrate FDP was monitored continuously on a Cytofluor microplate reader with excitation and emission wavelengths set at 440 and 515 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Human)
Merck Frosst Center For Therapeutic Research

LigandPNGBDBM13814(({4-[(4E)-2-(1H-1,2,3-benzotriazol-1-yl)-2-[4-(met...)
Affinity DataIC50: 39nMpH: 6.3 T: 2°CAssay Description:Hydrolysis of substrate FDP was monitored continuously on a Cytofluor microplate reader with excitation and emission wavelengths set at 440 and 515 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein phosphatase non-receptor type 1 [V113I](Human)
Merck Frosst Center For Therapeutic Research

LigandPNGBDBM13814(({4-[(4E)-2-(1H-1,2,3-benzotriazol-1-yl)-2-[4-(met...)
Affinity DataIC50: 39nMpH: 6.3 T: 2°CAssay Description:Hydrolysis of substrate FDP was monitored continuously on a Cytofluor microplate reader with excitation and emission wavelengths set at 440 and 515 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein phosphatase non-receptor type 1 [M114V](Human)
Merck Frosst Center For Therapeutic Research

LigandPNGBDBM13814(({4-[(4E)-2-(1H-1,2,3-benzotriazol-1-yl)-2-[4-(met...)
Affinity DataIC50: 45nMpH: 6.3 T: 2°CAssay Description:Hydrolysis of substrate FDP was monitored continuously on a Cytofluor microplate reader with excitation and emission wavelengths set at 440 and 515 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Merck Frosst Center For Therapeutic Research

LigandPNGBDBM13814(({4-[(4E)-2-(1H-1,2,3-benzotriazol-1-yl)-2-[4-(met...)
Affinity DataIC50: 87nMpH: 6.3 T: 2°CAssay Description:Hydrolysis of substrate FDP was monitored continuously on a Cytofluor microplate reader with excitation and emission wavelengths set at 440 and 515 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2007
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Merck Frosst Center For Therapeutic Research

LigandPNGBDBM13815(({4-[(4E)-2-(1H-1,2,3-benzotriazol-1-yl)-2,5-diphe...)
Affinity DataIC50: 95nMpH: 6.3 T: 2°CAssay Description:Hydrolysis of substrate FDP was monitored continuously on a Cytofluor microplate reader with excitation and emission wavelengths set at 440 and 515 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2007
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Human)
Merck Frosst Center For Therapeutic Research

LigandPNGBDBM13815(({4-[(4E)-2-(1H-1,2,3-benzotriazol-1-yl)-2,5-diphe...)
Affinity DataIC50: 109nMpH: 6.3 T: 2°CAssay Description:Hydrolysis of substrate FDP was monitored continuously on a Cytofluor microplate reader with excitation and emission wavelengths set at 440 and 515 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2007
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 2 [V121L](Human)
Merck Frosst Center For Therapeutic Research

LigandPNGBDBM13816([difluoro({4-[3-(4-fluorophenyl)-2-[4-(3-methyl-1,...)
Affinity DataIC50: 138nMpH: 6.3 T: 2°CAssay Description:Hydrolysis of substrate FDP was monitored continuously on a Cytofluor microplate reader with excitation and emission wavelengths set at 440 and 515 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2007
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [L119V](Human)
Merck Frosst Center For Therapeutic Research

LigandPNGBDBM13814(({4-[(4E)-2-(1H-1,2,3-benzotriazol-1-yl)-2-[4-(met...)
Affinity DataIC50: 142nMpH: 6.3 T: 2°CAssay Description:Hydrolysis of substrate FDP was monitored continuously on a Cytofluor microplate reader with excitation and emission wavelengths set at 440 and 515 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Human)
Merck Frosst Center For Therapeutic Research

LigandPNGBDBM13816([difluoro({4-[3-(4-fluorophenyl)-2-[4-(3-methyl-1,...)
Affinity DataIC50: 163nMpH: 6.3 T: 2°CAssay Description:Hydrolysis of substrate FDP was monitored continuously on a Cytofluor microplate reader with excitation and emission wavelengths set at 440 and 515 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2007
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Merck Frosst Center For Therapeutic Research

LigandPNGBDBM13816([difluoro({4-[3-(4-fluorophenyl)-2-[4-(3-methyl-1,...)
Affinity DataIC50: 1.60E+3nMpH: 6.3 T: 2°CAssay Description:Hydrolysis of substrate FDP was monitored continuously on a Cytofluor microplate reader with excitation and emission wavelengths set at 440 and 515 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2007
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [L119V](Human)
Merck Frosst Center For Therapeutic Research

LigandPNGBDBM13816([difluoro({4-[3-(4-fluorophenyl)-2-[4-(3-methyl-1,...)
Affinity DataIC50: 1.90E+3nMpH: 6.3 T: 2°CAssay Description:Hydrolysis of substrate FDP was monitored continuously on a Cytofluor microplate reader with excitation and emission wavelengths set at 440 and 515 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2007
Entry Details Article
PubMed