Compile Data Set for Download or QSAR
Report error Found 17 Enz. Inhib. hit(s) with all data for entry = 50017314
TargetBeta-secretase 1(Human)
University of The Mediterranean

Curated by ChEMBL
LigandPNGBDBM50180393(tert-butyl 4-(4-bromo-2-(2-(7-methoxy-2-oxo-2H-chr...)
Affinity DataIC50: 93nMAssay Description:Inhibition of BACE1 activity by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
University of The Mediterranean

Curated by ChEMBL
LigandPNGBDBM16741(2,2,2-trifluoroacetic acid; N-[5-bromo-2-(piperazi...)
Affinity DataIC50: 670nMAssay Description:Inhibition of BACE1 activity by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
University of The Mediterranean

Curated by ChEMBL
LigandPNGBDBM16740(CHEMBL206442 | N-[2-(4-benzylpiperazin-1-yl)-5-bro...)
Affinity DataIC50: 760nMAssay Description:Inhibition of BACE1 activity by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
University of The Mediterranean

Curated by ChEMBL
LigandPNGBDBM16739(CHEMBL207083 | tert-butyl 4-{4-bromo-2-[(2-oxo-2H-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of BACE1 activity by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
University of The Mediterranean

Curated by ChEMBL
LigandPNGBDBM16726(N-[5-bromo-2-(piperazin-1-yl)phenyl]naphthalene-1-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of BACE1 activity by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
University of The Mediterranean

Curated by ChEMBL
LigandPNGBDBM50180395(N-(5-bromo-2-(4-(thiophen-2-ylsulfonyl)piperazin-1...)
Affinity DataIC50: 1.13E+3nMAssay Description:Inhibition of BACE1 activity by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
University of The Mediterranean

Curated by ChEMBL
LigandPNGBDBM50180396(4-Oxo-4H-chromene-2-carboxylic acid (5-bromo-2-pip...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of BACE1 activity by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
University of The Mediterranean

Curated by ChEMBL
LigandPNGBDBM16724(CHEMBL381618 | tert-butyl 4-[4-bromo-2-(naphthalen...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of BACE1 activity by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
University of The Mediterranean

Curated by ChEMBL
LigandPNGBDBM50180394(N-(5-bromo-2-piperazin-1-yl-phenyl)-2-(7-methoxy-2...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of BACE1 activity by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
University of The Mediterranean

Curated by ChEMBL
LigandPNGBDBM50180391(tert-butyl 4-(4-bromo-2-(quinoline-2-carboxamido)p...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of BACE1 activity by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
University of The Mediterranean

Curated by ChEMBL
LigandPNGBDBM50180398(tert-butyl 4-(4-bromo-2-(4-oxo-4H-chromene-2-carbo...)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of BACE1 activity by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
University of The Mediterranean

Curated by ChEMBL
LigandPNGBDBM16744(tert-butyl 4-{4-bromo-2-[(8-methoxy-2-oxo-2H-chrom...)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of BACE1 activity by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
University of The Mediterranean

Curated by ChEMBL
LigandPNGBDBM50180399(N-(5-bromo-2-(4-(thiophen-2-ylsulfonyl)piperazin-1...)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of BACE1 activity by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
University of The Mediterranean

Curated by ChEMBL
LigandPNGBDBM50180392(quinoline-2-carboxylic acid (5-bromo-2-piperazin-1...)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of BACE1 activity by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
University of The Mediterranean

Curated by ChEMBL
LigandPNGBDBM16746(CHEMBL206557 | CHEMBL1165583 | 2,2,2-trifluoroacet...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of BACE1 activity by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
University of The Mediterranean

Curated by ChEMBL
LigandPNGBDBM16725(N-[2-(4-benzylpiperazin-1-yl)-5-bromophenyl]naphth...)
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of BACE1 activity by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
University of The Mediterranean

Curated by ChEMBL
LigandPNGBDBM16745(CHEMBL381617 | N-[2-(4-benzylpiperazin-1-yl)-5-bro...)
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of BACE1 activity by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed