Compile Data Set for Download or QSAR
Report error Found 9 Enz. Inhib. hit(s) with all data for entry = 1605
TargetProthrombin(Human)
Astex

LigandPNGBDBM12588((2R,3S)-3-({[5-chloro-2-(1H-1,2,3,4-tetrazol-1-yl)...)
Affinity DataIC50: 1.40nMpH: 8.0 T: 2°CAssay Description:The cleavage of the substrate was followed by monitoring the change in fluorescence at 460 nm (excitation at 365 nm) for 25 min at room temperature o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2006
Entry Details Article
PubMed
TargetProthrombin(Human)
Astex

LigandPNGBDBM12589((2R,3S)-3-({[5-chloro-2-(1H-1,2,3,4-tetrazol-1-yl)...)
Affinity DataIC50: 3.70nMpH: 8.0 T: 2°CAssay Description:The cleavage of the substrate was followed by monitoring the change in fluorescence at 460 nm (excitation at 365 nm) for 25 min at room temperature o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2006
Entry Details Article
PubMed
TargetProthrombin(Human)
Astex

LigandPNGBDBM12587((2R,3S)-3-{[(3-chlorophenyl)methyl]amino}-2-hydrox...)
Affinity DataIC50: 220nMpH: 8.0 T: 2°CAssay Description:The cleavage of the substrate was followed by monitoring the change in fluorescence at 460 nm (excitation at 365 nm) for 25 min at room temperature o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2006
Entry Details Article
PubMed
TargetProthrombin(Human)
Astex

LigandPNGBDBM12586(CHEMBL379692 | (2R,3S)-3-amino-2-hydroxy-N-(4-meth...)
Affinity DataIC50: 1.20E+4nMpH: 8.0 T: 2°CAssay Description:The cleavage of the substrate was followed by monitoring the change in fluorescence at 460 nm (excitation at 365 nm) for 25 min at room temperature o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2006
Entry Details Article
PubMed
TargetProthrombin(Human)
Astex

LigandPNGBDBM12590(acridine-3,6-diamine | (6-aminoacridin-3-yl)amine ...)
Affinity DataIC50: 1.20E+4nMpH: 8.0 T: 2°CAssay Description:The cleavage of the substrate was followed by monitoring the change in fluorescence at 460 nm (excitation at 365 nm) for 25 min at room temperature o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2006
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProthrombin(Human)
Astex

LigandPNGBDBM12585((2R,3S)-3-amino-2-hydroxy-N-(naphthalen-2-yl)-4-ph...)
Affinity DataIC50: 1.00E+5nMpH: 8.0 T: 2°CAssay Description:The cleavage of the substrate was followed by monitoring the change in fluorescence at 460 nm (excitation at 365 nm) for 25 min at room temperature o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2006
Entry Details Article
PubMed
TargetProthrombin(Human)
Astex

LigandPNGBDBM12584((3-chlorophenyl)methanamine | CHEMBL12957 | 1-(3-C...)
Affinity DataIC50: 3.00E+5nMpH: 8.0 T: 2°CAssay Description:The cleavage of the substrate was followed by monitoring the change in fluorescence at 460 nm (excitation at 365 nm) for 25 min at room temperature o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2006
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProthrombin(Human)
Astex

LigandPNGBDBM12582(CHEMBL440394 | 1-(4-chlorophenyl)-1H-1,2,3,4-tetra...)
Affinity DataIC50: 3.30E+5nMpH: 8.0 T: 2°CAssay Description:The cleavage of the substrate was followed by monitoring the change in fluorescence at 460 nm (excitation at 365 nm) for 25 min at room temperature o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2006
Entry Details Article
PubMed
TargetProthrombin(Human)
Astex

LigandPNGBDBM772(Benzamidine | benzamidine deriv. | [amino(phenyl)m...)
Affinity DataIC50: 4.40E+5nMpH: 8.0 T: 2°CAssay Description:The cleavage of the substrate was followed by monitoring the change in fluorescence at 460 nm (excitation at 365 nm) for 25 min at room temperature o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2006
Entry Details Article
PubMed