Compile Data Set for Download or QSAR
Report error Found 27 Enz. Inhib. hit(s) with all data for entry = 2746
LigandPNGBDBM24089((5S)-5-(3-aminopropyl)-3-(2,5-difluorophenyl)-N,N-...)
Affinity DataIC50: 1.90nMpH: 7.0 T: 2°CAssay Description:The kinesin motor domain is incubated with microtubules, 1 mM ATP (1: 1 MgCl2 : Na-ATP), and compound at 23°C in buffer. After reaction was term...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2008
Entry Details Article
PubMed
LigandPNGBDBM24084(5-(3-aminopropyl)-3-(2,5-difluorophenyl)-N,N-dimet...)
Affinity DataIC50: 8nMpH: 7.0 T: 2°CAssay Description:The kinesin motor domain is incubated with microtubules, 1 mM ATP (1: 1 MgCl2 : Na-ATP), and compound at 23°C in buffer. After reaction was term...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2008
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

LigandPNGBDBM24089((5S)-5-(3-aminopropyl)-3-(2,5-difluorophenyl)-N,N-...)
Affinity DataIC50: 19.3nMpH: 7.4 T: 2°CAssay Description:The hERG IC50 values were determined by radioligand competition experiments using membrane preparations from human embryonic kidney cells that stably...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2008
Entry Details Article
PubMed
LigandPNGBDBM24065(CHEMBL195232 | 1-[(5S)-3-(2,5-difluorophenyl)-5-(3...)
Affinity DataIC50: 24.7nMpH: 7.0 T: 2°CAssay Description:The kinesin motor domain is incubated with microtubules, 1 mM ATP (1: 1 MgCl2 : Na-ATP), and compound at 23°C in buffer. After reaction was term...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2008
Entry Details Article
PubMed
LigandPNGBDBM24086(3-[3-(2,5-difluorophenyl)-5-phenyl-1-(pyrrolidin-1...)
Affinity DataIC50: 26nMpH: 7.0 T: 2°CAssay Description:The kinesin motor domain is incubated with microtubules, 1 mM ATP (1: 1 MgCl2 : Na-ATP), and compound at 23°C in buffer. After reaction was term...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2008
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

LigandPNGBDBM24065(CHEMBL195232 | 1-[(5S)-3-(2,5-difluorophenyl)-5-(3...)
Affinity DataIC50: 26.4nMpH: 7.4 T: 2°CAssay Description:The hERG IC50 values were determined by radioligand competition experiments using membrane preparations from human embryonic kidney cells that stably...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2008
Entry Details Article
PubMed
LigandPNGBDBM24074(5-(3-aminopropyl)-3-(2,5-difluorophenyl)-N-ethyl-5...)
Affinity DataIC50: 44nMpH: 7.0 T: 2°CAssay Description:The kinesin motor domain is incubated with microtubules, 1 mM ATP (1: 1 MgCl2 : Na-ATP), and compound at 23°C in buffer. After reaction was term...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2008
Entry Details Article
PubMed
LigandPNGBDBM24085(3-[1-(azetidin-1-ylcarbonyl)-3-(2,5-difluorophenyl...)
Affinity DataIC50: 55nMpH: 7.0 T: 2°CAssay Description:The kinesin motor domain is incubated with microtubules, 1 mM ATP (1: 1 MgCl2 : Na-ATP), and compound at 23°C in buffer. After reaction was term...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2008
Entry Details Article
PubMed
LigandPNGBDBM24075(5-(4-aminobutyl)-3-(2,5-difluorophenyl)-N-ethyl-5-...)
Affinity DataIC50: 67nMpH: 7.0 T: 2°CAssay Description:The kinesin motor domain is incubated with microtubules, 1 mM ATP (1: 1 MgCl2 : Na-ATP), and compound at 23°C in buffer. After reaction was term...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2008
Entry Details Article
PubMed
LigandPNGBDBM24087(3-[3-(2,5-difluorophenyl)-5-phenyl-1-(piperidin-1-...)
Affinity DataIC50: 85nMpH: 7.0 T: 2°CAssay Description:The kinesin motor domain is incubated with microtubules, 1 mM ATP (1: 1 MgCl2 : Na-ATP), and compound at 23°C in buffer. After reaction was term...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2008
Entry Details Article
PubMed
LigandPNGBDBM24076(5-[4-(benzylamino)butyl]-3-(2,5-difluorophenyl)-N-...)
Affinity DataIC50: 100nMpH: 7.0 T: 2°CAssay Description:The kinesin motor domain is incubated with microtubules, 1 mM ATP (1: 1 MgCl2 : Na-ATP), and compound at 23°C in buffer. After reaction was term...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2008
Entry Details Article
PubMed
LigandPNGBDBM24077(3-(2,5-difluorophenyl)-5-[4-(dimethylamino)butyl]-...)
Affinity DataIC50: 103nMpH: 7.0 T: 2°CAssay Description:The kinesin motor domain is incubated with microtubules, 1 mM ATP (1: 1 MgCl2 : Na-ATP), and compound at 23°C in buffer. After reaction was term...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2008
Entry Details Article
PubMed
LigandPNGBDBM24078(5-(4-{2-azabicyclo[2.2.1]hept-5-en-2-yl}butyl)-3-(...)
Affinity DataIC50: 119nMpH: 7.0 T: 2°CAssay Description:The kinesin motor domain is incubated with microtubules, 1 mM ATP (1: 1 MgCl2 : Na-ATP), and compound at 23°C in buffer. After reaction was term...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2008
Entry Details Article
PubMed
LigandPNGBDBM24088(3-[3-(2,5-difluorophenyl)-1-(morpholin-4-ylcarbony...)
Affinity DataIC50: 122nMpH: 7.0 T: 2°CAssay Description:The kinesin motor domain is incubated with microtubules, 1 mM ATP (1: 1 MgCl2 : Na-ATP), and compound at 23°C in buffer. After reaction was term...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2008
Entry Details Article
PubMed
LigandPNGBDBM24068(3-(2,5-difluorophenyl)-N,5-dimethyl-5-phenyl-4,5-d...)
Affinity DataIC50: 284nMpH: 7.0 T: 2°CAssay Description:The kinesin motor domain is incubated with microtubules, 1 mM ATP (1: 1 MgCl2 : Na-ATP), and compound at 23°C in buffer. After reaction was term...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2008
Entry Details Article
PubMed
LigandPNGBDBM24073(5-(2-aminoethyl)-3-(2,5-difluorophenyl)-N-ethyl-5-...)
Affinity DataIC50: 390nMpH: 7.0 T: 2°CAssay Description:The kinesin motor domain is incubated with microtubules, 1 mM ATP (1: 1 MgCl2 : Na-ATP), and compound at 23°C in buffer. After reaction was term...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2008
Entry Details Article
PubMed
LigandPNGBDBM24081(N-{4-[3-(2,5-difluorophenyl)-1-(ethylcarbamoyl)-5-...)
Affinity DataIC50: 391nMpH: 7.0 T: 2°CAssay Description:The kinesin motor domain is incubated with microtubules, 1 mM ATP (1: 1 MgCl2 : Na-ATP), and compound at 23°C in buffer. After reaction was term...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2008
Entry Details Article
PubMed
LigandPNGBDBM24066(1-[(5S)-3-(2-chlorophenyl)-5-(3-hydroxyphenyl)-4,5...)
Affinity DataIC50: 450nMpH: 7.0 T: 2°CAssay Description:The kinesin motor domain is incubated with microtubules, 1 mM ATP (1: 1 MgCl2 : Na-ATP), and compound at 23°C in buffer. After reaction was term...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2008
Entry Details Article
PubMed
LigandPNGBDBM24082(N-{4-[3-(2,5-difluorophenyl)-1-(ethylcarbamoyl)-5-...)
Affinity DataIC50: 552nMpH: 7.0 T: 2°CAssay Description:The kinesin motor domain is incubated with microtubules, 1 mM ATP (1: 1 MgCl2 : Na-ATP), and compound at 23°C in buffer. After reaction was term...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2008
Entry Details Article
PubMed
LigandPNGBDBM24079(4-[3-(2,5-difluorophenyl)-1-(ethylcarbamoyl)-5-phe...)
Affinity DataIC50: 585nMpH: 7.0 T: 2°CAssay Description:The kinesin motor domain is incubated with microtubules, 1 mM ATP (1: 1 MgCl2 : Na-ATP), and compound at 23°C in buffer. After reaction was term...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2008
Entry Details Article
PubMed
LigandPNGBDBM24070(3-(2,5-difluorophenyl)-N-ethyl-5-(2-hydroxyethyl)-...)
Affinity DataIC50: 606nMpH: 7.0 T: 2°CAssay Description:The kinesin motor domain is incubated with microtubules, 1 mM ATP (1: 1 MgCl2 : Na-ATP), and compound at 23°C in buffer. After reaction was term...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2008
Entry Details Article
PubMed
LigandPNGBDBM24083(N-{4-[3-(2,5-difluorophenyl)-1-(ethylcarbamoyl)-5-...)
Affinity DataIC50: 686nMpH: 7.0 T: 2°CAssay Description:The kinesin motor domain is incubated with microtubules, 1 mM ATP (1: 1 MgCl2 : Na-ATP), and compound at 23°C in buffer. After reaction was term...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2008
Entry Details Article
PubMed
LigandPNGBDBM24072(3-(2,5-difluorophenyl)-N-ethyl-5-(4-hydroxybutyl)-...)
Affinity DataIC50: 697nMpH: 7.0 T: 2°CAssay Description:The kinesin motor domain is incubated with microtubules, 1 mM ATP (1: 1 MgCl2 : Na-ATP), and compound at 23°C in buffer. After reaction was term...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2008
Entry Details Article
PubMed
LigandPNGBDBM24071(3-(2,5-difluorophenyl)-N-ethyl-5-(3-hydroxypropyl)...)
Affinity DataIC50: 745nMpH: 7.0 T: 2°CAssay Description:The kinesin motor domain is incubated with microtubules, 1 mM ATP (1: 1 MgCl2 : Na-ATP), and compound at 23°C in buffer. After reaction was term...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2008
Entry Details Article
PubMed
LigandPNGBDBM24080(3-(2,5-difluorophenyl)-N-ethyl-5-phenyl-5-[4-(phen...)
Affinity DataIC50: 892nMpH: 7.0 T: 2°CAssay Description:The kinesin motor domain is incubated with microtubules, 1 mM ATP (1: 1 MgCl2 : Na-ATP), and compound at 23°C in buffer. After reaction was term...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2008
Entry Details Article
PubMed
LigandPNGBDBM24069(3-(2,5-difluorophenyl)-5-(hydroxymethyl)-N-methyl-...)
Affinity DataIC50: 903nMpH: 7.0 T: 2°CAssay Description:The kinesin motor domain is incubated with microtubules, 1 mM ATP (1: 1 MgCl2 : Na-ATP), and compound at 23°C in buffer. After reaction was term...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2008
Entry Details Article
PubMed
LigandPNGBDBM24067(CHEMBL193686 | 3-(2,5-difluorophenyl)-N-methyl-5-p...)
Affinity DataIC50: 3.14E+3nMpH: 7.0 T: 2°CAssay Description:The kinesin motor domain is incubated with microtubules, 1 mM ATP (1: 1 MgCl2 : Na-ATP), and compound at 23°C in buffer. After reaction was term...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2008
Entry Details Article
PubMed