Compile Data Set for Download or QSAR
Report error Found 63 Enz. Inhib. hit(s) with all data for entry = 50017945
LigandPNGBDBM50188913(N-((S)-1-amino-3-(2,4-dichlorophenyl)propan-2-yl)-...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of PKAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of PKAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein kinase C alpha type(Human)
Chiron

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 1nMAssay Description:Inhibition of PKCaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 1nMAssay Description:Inhibition of KitMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 1nMAssay Description:Inhibition of CamK2alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50188913(N-((S)-1-amino-3-(2,4-dichlorophenyl)propan-2-yl)-...)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of AKT3 in presence of 0.2 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50188913(N-((S)-1-amino-3-(2,4-dichlorophenyl)propan-2-yl)-...)
Affinity DataIC50: 3nMAssay Description:Inhibition of AKT3 in presence of 0.2 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50188945(N-(1-amino-3-(2,4-dichlorophenyl)propan-2-yl)-5-(2...)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of AKT3 in presence of 0.2 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 5nMAssay Description:Inhibition of AKT3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50188913(N-((S)-1-amino-3-(2,4-dichlorophenyl)propan-2-yl)-...)
Affinity DataIC50: 6nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 9nMAssay Description:Inhibition of AKT2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 11nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50188929(N-((S)-1-(2,4-dichlorophenyl)-3-(dimethylamino)pro...)
Affinity DataIC50: 11nMAssay Description:Inhibition of AKT3 in presence of 0.2 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3(Human)
Chiron

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 12nMAssay Description:Inhibition of GSK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50188913(N-((S)-1-amino-3-(2,4-dichlorophenyl)propan-2-yl)-...)
Affinity DataIC50: 23nMAssay Description:Inhibition of AKT2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50188927(N-((S)-4-amino-1-(2,4-dichlorophenyl)butan-2-yl)-5...)
Affinity DataIC50: 27nMAssay Description:Inhibition of AKT3 in presence of 0.2 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein kinase C alpha type(Human)
Chiron

Curated by ChEMBL
LigandPNGBDBM50188913(N-((S)-1-amino-3-(2,4-dichlorophenyl)propan-2-yl)-...)
Affinity DataIC50: 66nMAssay Description:Inhibition of PKCaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50188913(N-((S)-1-amino-3-(2,4-dichlorophenyl)propan-2-yl)-...)
Affinity DataIC50: 110nMAssay Description:Inhibition of KitMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Chiron

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 130nMAssay Description:Inhibition of MetMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 140nMAssay Description:Inhibition of RAF1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50188913(N-((S)-1-amino-3-(2,4-dichlorophenyl)propan-2-yl)-...)
Affinity DataEC50:  160nMAssay Description:Activity against AKT-mediated PRAS40 T246P phosphorylation in human DOV13 cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50188941(N-((R)-1-amino-3-(2,4-dichlorophenyl)propan-2-yl)-...)
Affinity DataIC50: 240nMAssay Description:Inhibition of AKT3 in presence of 0.2 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50188944(N-((S)-3-(2,4-dichlorophenyl)-1-hydroxypropan-2-yl...)
Affinity DataIC50: 280nMAssay Description:Inhibition of AKT3 in presence of 0.2 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50188913(N-((S)-1-amino-3-(2,4-dichlorophenyl)propan-2-yl)-...)
Affinity DataEC50:  320nMAssay Description:Activity against AKT-mediated GSK3 S9P phosphorylation in human DOV13 cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50188913(N-((S)-1-amino-3-(2,4-dichlorophenyl)propan-2-yl)-...)
Affinity DataEC50:  370nMAssay Description:Activity against AKT-mediated S6RP S235/236P phosphorylation in human DOV13 cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 3(Human)
Chiron

Curated by ChEMBL
LigandPNGBDBM50188913(N-((S)-1-amino-3-(2,4-dichlorophenyl)propan-2-yl)-...)
Affinity DataIC50: 400nMAssay Description:Inhibition of ERK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50188947(N-(2,4-dichlorophenethyl)-5-(2-aminopyrimidin-4-yl...)
Affinity DataIC50: 610nMAssay Description:Inhibition of AKT3 in presence of 0.2 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50188942(N-(2-(2,4-dichlorophenyl)propyl)-5-(2-(methylamino...)
Affinity DataIC50: 660nMAssay Description:Inhibition of AKT3 in presence of 0.2 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50188946(N-((R)-1-(2,4-dichlorophenyl)propan-2-yl)-5-(2-(me...)
Affinity DataIC50: 820nMAssay Description:Inhibition of AKT3 in presence of 0.2 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50188912(N-(2,4-dichlorophenethyl)-5-(2-(methylamino)pyrimi...)
Affinity DataIC50: 990nMAssay Description:Inhibition of AKT3 in presence of 0.2 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50188918(N-(2-(2,4-dichlorophenyl)butyl)-5-(2-(methylamino)...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of AKT3 in presence of 0.2 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50188928(N-(4-chlorophenethyl)-5-(2-(methylamino)pyrimidin-...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of AKT3 in presence of 0.2 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Chiron

Curated by ChEMBL
LigandPNGBDBM50188913(N-((S)-1-amino-3-(2,4-dichlorophenyl)propan-2-yl)-...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of MetMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50188926(N-(2-aminoethyl)-5-(2-(methylamino)pyrimidin-4-yl)...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of AKT3 in presence of 0.2 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50188923(N-(2,4-dichlorophenethyl)-5-(2-(ethylamino)pyrimid...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of AKT3 in presence of 0.2 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50188939(1-(2,4-dichlorobenzyl)-3-(5-(2-(methylamino)pyrimi...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of AKT3 in presence of 0.2 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50188919(3-(4-fluorophenyl)-N-(5-(2-(methylamino)pyrimidin-...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of AKT3 in presence of 0.2 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50188916((2S)-methyl 3-(2,4-dichlorophenyl)-2-(2-(2-(methyl...)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of AKT3 in presence of 0.2 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50188936(N-(4-bromophenethyl)-5-(2-(methylamino)pyrimidin-4...)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of AKT3 in presence of 0.2 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50188933(N-((S)-2-amino-2-(2,4-dichlorophenyl)ethyl)-5-(2-(...)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of AKT3 in presence of 0.2 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50188932(N-(2-chlorophenethyl)-5-(2-(methylamino)pyrimidin-...)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of AKT3 in presence of 0.2 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50188924(N-(4-fluorophenethyl)-5-(2-(methylamino)pyrimidin-...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of AKT3 in presence of 0.2 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50188911(N-(4-fluorobenzyl)-5-(2-(methylamino)pyrimidin-4-y...)
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibition of AKT3 in presence of 0.2 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 3(Human)
Chiron

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 4.90E+3nMAssay Description:Inhibition of ERK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50188917(5-(2-(methylamino)pyrimidin-4-yl)-N-phenethylthiop...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of AKT3 in presence of 0.2 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50188922(4-(5-((2,4-dichlorophenethylamino)methyl)thiophen-...)
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of AKT3 in presence of 0.2 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50188915(N-(3-chlorophenethyl)-5-(2-(methylamino)pyrimidin-...)
Affinity DataIC50: 5.40E+3nMAssay Description:Inhibition of AKT3 in presence of 0.2 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50188920(N-(2-(dimethylamino)ethyl)-5-(2-(methylamino)pyrim...)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of AKT3 in presence of 0.2 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50188931(4-fluorobenzyl 5-(2-(methylamino)pyrimidin-4-yl)th...)
Affinity DataIC50: 7.40E+3nMAssay Description:Inhibition of AKT3 in presence of 0.2 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50188913(N-((S)-1-amino-3-(2,4-dichlorophenyl)propan-2-yl)-...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of CamK2alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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