Compile Data Set for Download or QSAR
Report error Found 42 Enz. Inhib. hit(s) with all data for entry = 50018216
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50192906(8S-hydroxylobel-9-ene | CHEMBL213613)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of [3H]MLA binding to alpha-7 nAChR in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50192907(10R-hydroxylobel-7-ene | CHEMBL217815)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of [3H]NIC binding to alpha-4-beta-2 nAChR in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50192904(10R-hydroxylobelane | CHEMBL213148)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of [3H]NIC binding to alpha-4-beta-2 nAChR in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50192906(8S-hydroxylobel-9-ene | CHEMBL213613)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of [3H]NIC binding to alpha-4-beta-2 nAChR in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50080826((S)-2-[(2S,6R)-1-Methyl-6-((E)-styryl)-piperidin-2...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of [3H]MLA binding to alpha-7 nAChR in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50192904(10R-hydroxylobelane | CHEMBL213148)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of [3H]MLA binding to alpha-7 nAChR in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50192905(8S-hydroxylobelane | CHEMBL377539)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of [3H]MLA binding to alpha-7 nAChR in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50192907(10R-hydroxylobel-7-ene | CHEMBL217815)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of [3H]MLA binding to alpha-7 nAChR in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSynaptic vesicular amine transporter(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50192902(Ro-4-1284 | 2-ethyl-3-isobutyl-9,10-dimethoxy-2,3,...)
Affinity DataKi:  28nMAssay Description:Inhibition of [3H]DTBZ binding to VMAT2 in rat synaptic vesicle membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50192903(8R-hydroxylobel-9-ene | CHEMBL425617)
Affinity DataKi:  44nMAssay Description:Inhibition of [3H]5-HT uptake at SERT in rat hippocampal synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50080826((S)-2-[(2S,6R)-1-Methyl-6-((E)-styryl)-piperidin-2...)
Affinity DataKi:  110nMAssay Description:Inhibition of [3H]DA uptake at DAT in rat striatal synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50080821((R)-2-((2R,6S)-1-Methyl-6-phenethyl-piperidin-2-yl...)
Affinity DataKi:  150nMAssay Description:Inhibition of [3H]5-HT uptake at SERT in rat hippocampal synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50192907(10R-hydroxylobel-7-ene | CHEMBL217815)
Affinity DataKi:  290nMAssay Description:Inhibition of [3H]DA uptake at DAT in rat striatal synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50192904(10R-hydroxylobelane | CHEMBL213148)
Affinity DataKi:  570nMAssay Description:Inhibition of [3H]DA uptake at DAT in rat striatal synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSynaptic vesicular amine transporter(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50192907(10R-hydroxylobel-7-ene | CHEMBL217815)
Affinity DataKi:  590nMAssay Description:Inhibition of [3H]DTBZ binding to VMAT2 in rat synaptic vesicle membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50192903(8R-hydroxylobel-9-ene | CHEMBL425617)
Affinity DataKi:  860nMAssay Description:Inhibition of [3H]DA uptake at DAT in rat striatal synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50192906(8S-hydroxylobel-9-ene | CHEMBL213613)
Affinity DataKi:  960nMAssay Description:Inhibition of [3H]DA uptake at DAT in rat striatal synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50080821((R)-2-((2R,6S)-1-Methyl-6-phenethyl-piperidin-2-yl...)
Affinity DataKi:  1.21E+3nMAssay Description:Inhibition of [3H]MLA binding to alpha-7 nAChR in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50192905(8S-hydroxylobelane | CHEMBL377539)
Affinity DataKi:  1.26E+3nMAssay Description:Inhibition of [3H]DA uptake at DAT in rat striatal synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50080814((S)-2-((2S,6R)-1-Methyl-6-phenethyl-piperidin-2-yl...)
Affinity DataKi:  1.39E+3nMAssay Description:Inhibition of [3H]DA uptake at DAT in rat striatal synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50192903(8R-hydroxylobel-9-ene | CHEMBL425617)
Affinity DataKi:  1.70E+3nMAssay Description:Inhibition of [3H]MLA binding to alpha-7 nAChR in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50080814((S)-2-((2S,6R)-1-Methyl-6-phenethyl-piperidin-2-yl...)
Affinity DataKi:  1.77E+3nMAssay Description:Inhibition of [3H]NIC binding to alpha-4-beta-2 nAChR in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50080821((R)-2-((2R,6S)-1-Methyl-6-phenethyl-piperidin-2-yl...)
Affinity DataKi:  1.88E+3nMAssay Description:Inhibition of [3H]DA uptake at DAT in rat striatal synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSynaptic vesicular amine transporter(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50080821((R)-2-((2R,6S)-1-Methyl-6-phenethyl-piperidin-2-yl...)
Affinity DataKi:  1.98E+3nMAssay Description:Inhibition of [3H]DTBZ binding to VMAT2 in rat synaptic vesicle membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50192905(8S-hydroxylobelane | CHEMBL377539)
Affinity DataKi:  2.22E+3nMAssay Description:Inhibition of [3H]5-HT uptake at SERT in rat hippocampal synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50080821((R)-2-((2R,6S)-1-Methyl-6-phenethyl-piperidin-2-yl...)
Affinity DataKi:  2.36E+3nMAssay Description:Inhibition of [3H]NIC binding to alpha-4-beta-2 nAChR in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSynaptic vesicular amine transporter(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50422013(Lobeline Hydrochloride | LOBELINE)
Affinity DataKi:  2.76E+3nMAssay Description:Inhibition of [3H]DTBZ binding to VMAT2 in rat synaptic vesicle membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSynaptic vesicular amine transporter(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50192905(8S-hydroxylobelane | CHEMBL377539)
Affinity DataKi:  3.01E+3nMAssay Description:Inhibition of [3H]DTBZ binding to VMAT2 in rat synaptic vesicle membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSynaptic vesicular amine transporter(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50080814((S)-2-((2S,6R)-1-Methyl-6-phenethyl-piperidin-2-yl...)
Affinity DataKi:  3.09E+3nMAssay Description:Inhibition of [3H]DTBZ binding to VMAT2 in rat synaptic vesicle membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50192906(8S-hydroxylobel-9-ene | CHEMBL213613)
Affinity DataKi:  3.75E+3nMAssay Description:Inhibition of [3H]5-HT uptake at SERT in rat hippocampal synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50192903(8R-hydroxylobel-9-ene | CHEMBL425617)
Affinity DataKi:  4.19E+3nMAssay Description:Inhibition of [3H]NIC binding to alpha-4-beta-2 nAChR in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50080814((S)-2-((2S,6R)-1-Methyl-6-phenethyl-piperidin-2-yl...)
Affinity DataKi:  4.27E+3nMAssay Description:Inhibition of [3H]5-HT uptake at SERT in rat hippocampal synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSynaptic vesicular amine transporter(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50192903(8R-hydroxylobel-9-ene | CHEMBL425617)
Affinity DataKi:  5.16E+3nMAssay Description:Inhibition of [3H]DTBZ binding to VMAT2 in rat synaptic vesicle membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSynaptic vesicular amine transporter(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50192906(8S-hydroxylobel-9-ene | CHEMBL213613)
Affinity DataKi:  6.06E+3nMAssay Description:Inhibition of [3H]DTBZ binding to VMAT2 in rat synaptic vesicle membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSynaptic vesicular amine transporter(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50080826((S)-2-[(2S,6R)-1-Methyl-6-((E)-styryl)-piperidin-2...)
Affinity DataKi:  6.44E+3nMAssay Description:Inhibition of [3H]DTBZ binding to VMAT2 in rat synaptic vesicle membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSynaptic vesicular amine transporter(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50192904(10R-hydroxylobelane | CHEMBL213148)
Affinity DataKi:  6.60E+3nMAssay Description:Inhibition of [3H]DTBZ binding to VMAT2 in rat synaptic vesicle membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50192904(10R-hydroxylobelane | CHEMBL213148)
Affinity DataKi:  7.30E+3nMAssay Description:Inhibition of [3H]5-HT uptake at SERT in rat hippocampal synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50192907(10R-hydroxylobel-7-ene | CHEMBL217815)
Affinity DataKi:  7.50E+3nMAssay Description:Inhibition of [3H]5-HT uptake at SERT in rat hippocampal synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50080826((S)-2-[(2S,6R)-1-Methyl-6-((E)-styryl)-piperidin-2...)
Affinity DataKi:  9.75E+3nMAssay Description:Inhibition of [3H]NIC binding to alpha-4-beta-2 nAChR in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50080826((S)-2-[(2S,6R)-1-Methyl-6-((E)-styryl)-piperidin-2...)
Affinity DataKi:  1.90E+4nMAssay Description:Inhibition of [3H]5-HT uptake at SERT in rat hippocampal synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50192905(8S-hydroxylobelane | CHEMBL377539)
Affinity DataKi:  3.36E+4nMAssay Description:Inhibition of [3H]NIC binding to alpha-4-beta-2 nAChR in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50080814((S)-2-((2S,6R)-1-Methyl-6-phenethyl-piperidin-2-yl...)
Affinity DataKi:  3.93E+4nMAssay Description:Inhibition of [3H]MLA binding to alpha-7 nAChR in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed