Compile Data Set for Download or QSAR
Report error Found 124 Enz. Inhib. hit(s) with all data for entry = 50018289
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194056(5-3-chloro-4-2,3-dichlorophenoxy)phenylamino)-3-hy...)
Affinity DataEC50: >10nMAssay Description:Inhibitory activity against MEK-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194036(5-3-chloro-4-2-chloro-5-fluorophenoxy)phenylamino)...)
Affinity DataEC50: >10nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk2(Human)
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50196392(3-hydroxy-N-1-hydroxypropan-2-yl)-5-4-phenylamino)...)
Affinity DataIC50: 13nMAssay Description:Inhibition of CHK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194053(5-4-2,3-difluorophenoxy)phenylamino)-3-hydroxy-N-1...)
Affinity DataIC50: 20nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194048(5-4-3,5-dichlorophenoxy)phenylamino)-3-hydroxy-N-1...)
Affinity DataIC50: 20nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194026(5-4-2,5-dichlorophenoxy)phenylamino)-N-3,4-dihydro...)
Affinity DataEC50:  22nMAssay Description:Inhibitory activity against MEK-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194030(5-4-2,5-dichlorophenoxy)-3-fluorophenylamino)-3-hy...)
Affinity DataIC50: 26nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194024(3-hydroxy-N-1-hydroxypropan-2-yl)-5-4-phenoxypheny...)
Affinity DataIC50: 26nMAssay Description:Inhibition of MEK-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194039(5-4-2-chloro-3,5-difluorophenoxy)-3-fluorophenylam...)
Affinity DataIC50: 27nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194056(5-3-chloro-4-2,3-dichlorophenoxy)phenylamino)-3-hy...)
Affinity DataIC50: 27nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194041(5-4-2,5-dichlorophenoxy)phenylamino)-3-hydroxy-N-2...)
Affinity DataIC50: 28nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194061(5-4-2,5-dichlorophenoxy)phenylamino)-3-hydroxy-N-1...)
Affinity DataIC50: 30nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194036(5-3-chloro-4-2-chloro-5-fluorophenoxy)phenylamino)...)
Affinity DataIC50: 30nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194067(5-4-3-fluoro-5-trifluoromethyl)phenoxy)phenylamino...)
Affinity DataEC50:  30nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194051(5-4-2,5-dichlorophenoxy)phenylamino)-3-hydroxy-N-m...)
Affinity DataIC50: 32nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194024(3-hydroxy-N-1-hydroxypropan-2-yl)-5-4-phenoxypheny...)
Affinity DataIC50: 33nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194026(5-4-2,5-dichlorophenoxy)phenylamino)-N-3,4-dihydro...)
Affinity DataIC50: 34nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194023(5-4-2,5-dichlorophenoxy)phenylamino)-3-hydroxy-N-t...)
Affinity DataIC50: 34nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194031(5-4-2,5-dichlorophenoxy)phenylamino)-3-hydroxy-N-4...)
Affinity DataIC50: 34nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194045(5-4-2,5-dichlorophenoxy)phenylamino)-N-1,3-dihydro...)
Affinity DataIC50: 35nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194034(5-4-2,5-dichlorophenoxy)phenylamino)-3-hydroxy-N-2...)
Affinity DataEC50:  35nMAssay Description:Inhibitory activity against MEK-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194065(5-4-2-chloro-3,5-difluorophenoxy)phenylamino)-3-hy...)
Affinity DataIC50: 37nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194027(5-3-chloro-4-2-chloro-4-fluorophenoxy)phenylamino)...)
Affinity DataEC50:  37nMAssay Description:Inhibitory activity against MEK-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50187848(5-(2,3-dichlorophenylamino)-3-hydroxy-N-(1-hydroxy...)
Affinity DataIC50: 38nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194034(5-4-2,5-dichlorophenoxy)phenylamino)-3-hydroxy-N-2...)
Affinity DataIC50: 40nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194046(5-4-2,5-dichlorophenoxy)phenylamino)-3-hydroxy-N-1...)
Affinity DataIC50: 40nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50187817(5-(2-chloro-4-iodophenylamino)-3-hydroxy-N-isoprop...)
Affinity DataIC50: 42nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194053(5-4-2,3-difluorophenoxy)phenylamino)-3-hydroxy-N-1...)
Affinity DataEC50:  42nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194024(3-hydroxy-N-1-hydroxypropan-2-yl)-5-4-phenoxypheny...)
Affinity DataEC50:  42nMAssay Description:Inhibitory activity against MEK-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194025(5-4-2,5-dichlorophenoxy)phenylamino)-3-hydroxy-N-2...)
Affinity DataEC50:  43nMAssay Description:Inhibitory activity against MEK-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194016(3-hydroxy-N-1-hydroxypropan-2-yl)-5-4-3-trifluorom...)
Affinity DataIC50: 44nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194063(5-4-2,5-dichlorophenoxy)phenylamino)-3-hydroxy-N-2...)
Affinity DataIC50: 44nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194062(3-hydroxy-N-1-hydroxypropan-2-yl)-5-4-phenylthio)p...)
Affinity DataIC50: 45nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50196392(3-hydroxy-N-1-hydroxypropan-2-yl)-5-4-phenylamino)...)
Affinity DataEC50:  45nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194055(5-4-2,5-dichlorophenoxy)phenylamino)-N-2,3-dihydro...)
Affinity DataIC50: 46nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194028(5-4-2,5-dichlorophenoxy)phenylamino)-3-hydroxy-N-2...)
Affinity DataIC50: 46nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194028(5-4-2,5-dichlorophenoxy)phenylamino)-3-hydroxy-N-2...)
Affinity DataEC50:  47nMAssay Description:Inhibitory activity against MEK-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194051(5-4-2,5-dichlorophenoxy)phenylamino)-3-hydroxy-N-m...)
Affinity DataEC50:  47nMAssay Description:Inhibitory activity against MEK-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194063(5-4-2,5-dichlorophenoxy)phenylamino)-3-hydroxy-N-2...)
Affinity DataEC50:  49nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194059(5-4-2-chloro-3-trifluoromethyl)phenoxy)-3-fluoroph...)
Affinity DataIC50: 52nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194055(5-4-2,5-dichlorophenoxy)phenylamino)-N-2,3-dihydro...)
Affinity DataEC50:  54nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194019(5-4-2,5-dichlorophenoxy)phenylamino)-N-2,3-dihydro...)
Affinity DataIC50: 56nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194033(5-4-2-chloro-4-fluorophenoxy)-2-methylphenylamino)...)
Affinity DataIC50: 57nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194050(5-4-benzylphenylamino)-3-hydroxy-N-1-hydroxypropan...)
Affinity DataIC50: 58nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194058(5-4-2-fluoro-3-trifluoromethyl)phenoxy)phenylamino...)
Affinity DataIC50: 58nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194025(5-4-2,5-dichlorophenoxy)phenylamino)-3-hydroxy-N-2...)
Affinity DataIC50: 58nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194022(5-4-2-fluoro-5-trifluoromethyl)phenoxy)phenylamino...)
Affinity DataIC50: 60nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50187841(3-hydroxy-5-(4-iodo-2-methylphenylamino)-N-isoprop...)
Affinity DataIC50: 62nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194057(5-4-2,4-dichlorophenoxy)phenylamino)-3-hydroxy-N-1...)
Affinity DataIC50: 64nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Valeant Pharmaceuticals Research & Development

Curated by ChEMBL
LigandPNGBDBM50194023(5-4-2,5-dichlorophenoxy)phenylamino)-3-hydroxy-N-t...)
Affinity DataEC50:  65nMAssay Description:Inhibition of MEK-1 activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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