Compile Data Set for Download or QSAR
Report error Found 27 Enz. Inhib. hit(s) with all data for entry = 1654
TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM13014(7,8-Dichloro-1,2,3,4-tetrahydro-isoquinoline; hydr...)
Affinity DataKi:  3.10nM ΔG°:  -50.5kJ/molepH: 8.0 T: 2°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM13027(3-(hydroxymethyl)-N-(2,2,2-trifluoroethyl)-1,2,3,4...)
Affinity DataKi:  23nM ΔG°:  -45.4kJ/molepH: 8.0 T: 2°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2007
Entry Details Article
PubMed
TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM13023(CHEMBL41647 | 3-(hydroxymethyl)-1,2,3,4-tetrahydro...)
Affinity DataKi:  52nM ΔG°:  -43.2kJ/molepH: 8.0 T: 2°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2007
Entry Details Article
PubMed
TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM13025(CHEMBL176112 | N-(4-chlorophenyl)-3-(hydroxymethyl...)
Affinity DataKi:  63nM ΔG°:  -42.8kJ/molepH: 8.0 T: 2°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM13026(CHEMBL178695 | 3-(fluoromethyl)-N-(2,2,2-trifluoro...)
Affinity DataKi:  130nM ΔG°:  -40.9kJ/molepH: 8.0 T: 2°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2007
Entry Details Article
PubMed
TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM13022(3-(fluoromethyl)-1,2,3,4-tetrahydroisoquinoline-7-...)
Affinity DataKi:  150nM ΔG°:  -40.5kJ/molepH: 8.0 T: 2°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2007
Entry Details Article
PubMed
TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM13028(CHEMBL177621 | 3-(fluoromethyl)-N-(3,3,3-trifluoro...)
Affinity DataKi:  220nM ΔG°:  -39.5kJ/molepH: 8.0 T: 2°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2007
Entry Details Article
PubMed
TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM13024(CHEMBL290890 | N-(4-chlorophenyl)-3-(fluoromethyl)...)
Affinity DataKi:  270nM ΔG°:  -39.0kJ/molepH: 8.0 T: 2°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2007
Entry Details Article
PubMed
TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM13017(1,2,3,4-tetrahydroisoquinoline-7-sulfonamide | CHE...)
Affinity DataKi:  280nM ΔG°:  -38.9kJ/molepH: 8.0 T: 2°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM13018(CHEMBL27664 | 7-methanesulfonyl-1,2,3,4-tetrahydro...)
Affinity DataKi:  790nM ΔG°:  -36.2kJ/molepH: 8.0 T: 2°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2007
Entry Details Article
PubMed
TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM13041(3-(fluoromethyl)-7-methanesulfonyl-1,2,3,4-tetrahy...)
Affinity DataKi:  1.10E+3nM ΔG°:  -35.4kJ/molepH: 8.0 T: 2°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2007
Entry Details Article
PubMed
TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM13034(((+/-)-3-Fluoromethyl-7-(3,3,3-trifluoropropylsulf...)
Affinity DataKi:  1.30E+3nM ΔG°:  -34.9kJ/molepH: 8.0 T: 2°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2007
Entry Details Article
PubMed
TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM13030(CHEMBL177861 | N-ethyl-3-(fluoromethyl)-1,2,3,4-te...)
Affinity DataKi:  1.40E+3nM ΔG°:  -34.8kJ/molepH: 8.0 T: 2°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2007
Entry Details Article
PubMed
TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM13040(3-(fluoromethyl)-7-[(2,2,2-trifluoroethane)sulfony...)
Affinity DataKi:  1.40E+3nM ΔG°:  -34.8kJ/molepH: 8.0 T: 2°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2007
Entry Details Article
PubMed
TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM13031(3-(fluoromethyl)-N-propyl-1,2,3,4-tetrahydroisoqui...)
Affinity DataKi:  1.70E+3nM ΔG°:  -34.3kJ/molepH: 8.0 T: 2°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2007
Entry Details Article
PubMed
TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM13037(3-(fluoromethyl)-7-(propane-1-sulfonyl)-1,2,3,4-te...)
Affinity DataKi:  2.40E+3nM ΔG°:  -33.4kJ/molepH: 8.0 T: 2°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2007
Entry Details Article
PubMed
TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM13029(3-(fluoromethyl)-N-methyl-1,2,3,4-tetrahydroisoqui...)
Affinity DataKi:  3.70E+3nM ΔG°:  -32.3kJ/molepH: 8.0 T: 2°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2007
Entry Details Article
PubMed
TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM13032(3-(fluoromethyl)-N-(2-methoxyethyl)-1,2,3,4-tetrah...)
Affinity DataKi:  5.10E+3nM ΔG°:  -31.4kJ/molepH: 8.0 T: 2°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2007
Entry Details Article
PubMed
TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM13016(1,2,3,4-tetrahydroisoquinoline | THIQ 6 | tetrahyd...)
Affinity DataKi:  5.80E+3nM ΔG°:  -31.1kJ/molepH: 8.0 T: 2°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2007
Entry Details Article
PubMed
TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM13021(7-(trichloromethane)sulfonyl-1,2,3,4-tetrahydroiso...)
Affinity DataKi:  6.30E+3nM ΔG°:  -30.9kJ/molepH: 8.0 T: 2°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2007
Entry Details Article
PubMed
TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM13020(CHEMBL280592 | 7-(prop-2-ene-1-sulfonyl)-1,2,3,4-t...)
Affinity DataKi:  9.00E+3nM ΔG°:  -30.0kJ/molepH: 8.0 T: 2°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2007
Entry Details Article
PubMed
TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM13036(((+/-)-7-Ethylsulfonyl-3-fluoromethyl-1,2,3,4-tetr...)
Affinity DataKi:  1.40E+4nM ΔG°:  -28.8kJ/molepH: 8.0 T: 2°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2007
Entry Details Article
PubMed
TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM13038(7-(butane-1-sulfonyl)-3-(fluoromethyl)-1,2,3,4-tet...)
Affinity DataKi:  1.80E+4nM ΔG°:  -28.2kJ/molepH: 8.0 T: 2°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2007
Entry Details Article
PubMed
TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM13019(CHEMBL28431 | 7-(benzenesulfonyl)-1,2,3,4-tetrahyd...)
Affinity DataKi:  2.30E+4nM ΔG°:  -27.5kJ/molepH: 8.0 T: 2°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2007
Entry Details Article
PubMed
TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM13033(7-{[(4-chlorophenyl)methane]sulfonyl}-3-(fluoromet...)
Affinity DataKi:  3.20E+4nM ΔG°:  -26.7kJ/molepH: 8.0 T: 2°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2007
Entry Details Article
PubMed
TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM13035(((+/-)-3-Fluoromethyl-7-(4,4,4-trifluorobutylsulfo...)
Affinity DataKi:  6.70E+4nM ΔG°:  -24.8kJ/molepH: 8.0 T: 2°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2007
Entry Details Article
PubMed
TargetPhenylethanolamine N-methyltransferase(Human)
University of Kansas

LigandPNGBDBM13039(3-(fluoromethyl)-7-[(3-methoxypropane)sulfonyl]-1,...)
Affinity DataKi:  7.20E+4nM ΔG°:  -24.6kJ/molepH: 8.0 T: 2°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2007
Entry Details Article
PubMed