Compile Data Set for Download or QSAR
Report error Found 42 Enz. Inhib. hit(s) with all data for entry = 1555
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

LigandPNGBDBM12133([5-(3-{5-[(4-fluoropiperidin-1-yl)methyl]-1H-indol...)
Affinity DataIC50: 0.110nMpH: 7.5 T: 2°CAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2006
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

LigandPNGBDBM12134(2-methoxy-4-{3-[5-(piperidin-1-ylmethyl)-1H-indol-...)
Affinity DataIC50: 0.25nMpH: 7.5 T: 2°CAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2006
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

LigandPNGBDBM12131((5-{3-[5-(piperidin-1-ylmethyl)-1H-indol-2-yl]-1H-...)
Affinity DataIC50: 0.300nMpH: 7.5 T: 2°CAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2006
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

LigandPNGBDBM12132([5-(3-{5-[(4-fluoropiperidin-1-yl)methyl]-1H-indol...)
Affinity DataIC50: 0.300nMpH: 7.5 T: 2°CAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2006
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

LigandPNGBDBM12112(1-[4-({2-[6-(1H-1,2,3,4-tetrazol-5-yl)-1H-indazol-...)
Affinity DataIC50: 2.30nMpH: 7.5 T: 2°CAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2006
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

LigandPNGBDBM12126(3-[5-(piperidin-1-ylmethyl)-1H-indol-2-yl]-6-(1H-1...)
Affinity DataIC50: 2.60nMpH: 7.5 T: 2°CAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2006
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

LigandPNGBDBM12121(4-({2-[6-(1H-pyrazol-4-yl)-1H-indazol-3-yl]-1H-ind...)
Affinity DataIC50: 10nMpH: 7.5 T: 2°CAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2006
Entry Details Article
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Merck Research Laboratories

LigandPNGBDBM12116(3-[5-(morpholin-4-ylmethyl)-1H-indol-2-yl]-1H-inda...)
Affinity DataIC50: 11nMAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2006
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

LigandPNGBDBM12118(3-[5-(morpholin-4-ylmethyl)-1H-indol-2-yl]-1H-inda...)
Affinity DataIC50: 12nMpH: 7.5 T: 2°CAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2006
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

LigandPNGBDBM12124(4-{3-[5-(piperidin-1-ylmethyl)-1H-indol-2-yl]-1H-i...)
Affinity DataIC50: 12nMpH: 7.5 T: 2°CAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2006
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

LigandPNGBDBM12119(N-methyl-3-[5-(morpholin-4-ylmethyl)-1H-indol-2-yl...)
Affinity DataIC50: 13nMpH: 7.5 T: 2°CAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2006
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

LigandPNGBDBM12113(3-{5-[(4-acetylpiperazin-1-yl)methyl]-1H-indol-2-y...)
Affinity DataIC50: 17nMpH: 7.5 T: 2°CAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2006
Entry Details Article
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Merck Research Laboratories

LigandPNGBDBM12124(4-{3-[5-(piperidin-1-ylmethyl)-1H-indol-2-yl]-1H-i...)
Affinity DataIC50: 18nMAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2006
Entry Details Article
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Merck Research Laboratories

LigandPNGBDBM12121(4-({2-[6-(1H-pyrazol-4-yl)-1H-indazol-3-yl]-1H-ind...)
Affinity DataIC50: 25nMAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2006
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

LigandPNGBDBM12111(3-(1H-indol-2-yl)-6-(1H-1,2,3,4-tetrazol-5-yl)-1H-...)
Affinity DataIC50: 27nMpH: 7.5 T: 2°CAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2006
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

LigandPNGBDBM12116(3-[5-(morpholin-4-ylmethyl)-1H-indol-2-yl]-1H-inda...)
Affinity DataIC50: 30nMpH: 7.5 T: 2°CAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2006
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

LigandPNGBDBM12127(6-(5-methyl-1H-1,2,3-triazol-1-yl)-3-[5-(piperidin...)
Affinity DataIC50: 30nMpH: 7.5 T: 2°CAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2006
Entry Details Article
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Merck Research Laboratories

LigandPNGBDBM12123(4-({2-[6-(1H-pyrazol-5-yl)-1H-indazol-3-yl]-1H-ind...)
Affinity DataIC50: 34nMAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2006
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

LigandPNGBDBM12129(3-[5-(piperidin-1-ylmethyl)-1H-indol-2-yl]-6-(2H-1...)
Affinity DataIC50: 34nMpH: 7.5 T: 2°CAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2006
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

LigandPNGBDBM12130(6-phenyl-3-[5-(piperidin-1-ylmethyl)-1H-indol-2-yl...)
Affinity DataIC50: 45nMpH: 7.5 T: 2°CAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2006
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

LigandPNGBDBM12125(2-{3-[5-(piperidin-1-ylmethyl)-1H-indol-2-yl]-1H-i...)
Affinity DataIC50: 48nMpH: 7.5 T: 2°CAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2006
Entry Details Article
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Merck Research Laboratories

LigandPNGBDBM12131((5-{3-[5-(piperidin-1-ylmethyl)-1H-indol-2-yl]-1H-...)
Affinity DataIC50: 56nMAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2006
Entry Details Article
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Merck Research Laboratories

LigandPNGBDBM12126(3-[5-(piperidin-1-ylmethyl)-1H-indol-2-yl]-6-(1H-1...)
Affinity DataIC50: 57nMAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2006
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

LigandPNGBDBM12123(4-({2-[6-(1H-pyrazol-5-yl)-1H-indazol-3-yl]-1H-ind...)
Affinity DataIC50: 59nMpH: 7.5 T: 2°CAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2006
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

LigandPNGBDBM12117(methyl 3-[5-(morpholin-4-ylmethyl)-1H-indol-2-yl]-...)
Affinity DataIC50: 62nMpH: 7.5 T: 2°CAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2006
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

LigandPNGBDBM12120(N,N-dimethyl-3-[5-(morpholin-4-ylmethyl)-1H-indol-...)
Affinity DataIC50: 80nMpH: 7.5 T: 2°CAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2006
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

LigandPNGBDBM12128(3-[5-(piperidin-1-ylmethyl)-1H-indol-2-yl]-6-(1H-p...)
Affinity DataIC50: 110nMpH: 7.5 T: 2°CAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2006
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

LigandPNGBDBM12114(1-(4-{[2-(6-chloro-1H-indazol-3-yl)-1H-indol-5-yl]...)
Affinity DataIC50: 120nMpH: 7.5 T: 2°CAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2006
Entry Details Article
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Merck Research Laboratories

LigandPNGBDBM12132([5-(3-{5-[(4-fluoropiperidin-1-yl)methyl]-1H-indol...)
Affinity DataIC50: 180nMAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2006
Entry Details Article
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Merck Research Laboratories

LigandPNGBDBM12133([5-(3-{5-[(4-fluoropiperidin-1-yl)methyl]-1H-indol...)
Affinity DataIC50: 300nMAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2006
Entry Details Article
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Merck Research Laboratories

LigandPNGBDBM12134(2-methoxy-4-{3-[5-(piperidin-1-ylmethyl)-1H-indol-...)
Affinity DataIC50: 310nMAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2006
Entry Details Article
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Merck Research Laboratories

LigandPNGBDBM12127(6-(5-methyl-1H-1,2,3-triazol-1-yl)-3-[5-(piperidin...)
Affinity DataIC50: 420nMAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2006
Entry Details Article
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Merck Research Laboratories

LigandPNGBDBM12129(3-[5-(piperidin-1-ylmethyl)-1H-indol-2-yl]-6-(2H-1...)
Affinity DataIC50: 480nMAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2006
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

LigandPNGBDBM12122(4-({2-[6-(1-methyl-1H-pyrazol-4-yl)-1H-indazol-3-y...)
Affinity DataIC50: 530nMpH: 7.5 T: 2°CAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2006
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

LigandPNGBDBM12115(1-(4-{[2-(1H-indazol-3-yl)-1H-indol-5-yl]methyl}pi...)
Affinity DataIC50: 640nMpH: 7.5 T: 2°CAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2006
Entry Details Article
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Merck Research Laboratories

LigandPNGBDBM12118(3-[5-(morpholin-4-ylmethyl)-1H-indol-2-yl]-1H-inda...)
Affinity DataIC50: 1.30E+3nMAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2006
Entry Details Article
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Merck Research Laboratories

LigandPNGBDBM12128(3-[5-(piperidin-1-ylmethyl)-1H-indol-2-yl]-6-(1H-p...)
Affinity DataIC50: 2.30E+3nMAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2006
Entry Details Article
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Merck Research Laboratories

LigandPNGBDBM12125(2-{3-[5-(piperidin-1-ylmethyl)-1H-indol-2-yl]-1H-i...)
Affinity DataIC50: 4.00E+3nMAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2006
Entry Details Article
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Merck Research Laboratories

LigandPNGBDBM12119(N-methyl-3-[5-(morpholin-4-ylmethyl)-1H-indol-2-yl...)
Affinity DataIC50: 4.90E+3nMAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2006
Entry Details Article
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Merck Research Laboratories

LigandPNGBDBM12117(methyl 3-[5-(morpholin-4-ylmethyl)-1H-indol-2-yl]-...)
Affinity DataIC50: 6.50E+3nMAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2006
Entry Details Article
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Merck Research Laboratories

LigandPNGBDBM12130(6-phenyl-3-[5-(piperidin-1-ylmethyl)-1H-indol-2-yl...)
Affinity DataIC50: 7.00E+3nMAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2006
Entry Details Article
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Merck Research Laboratories

LigandPNGBDBM12120(N,N-dimethyl-3-[5-(morpholin-4-ylmethyl)-1H-indol-...)
Affinity DataIC50: 1.00E+5nMAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2006
Entry Details Article
PubMed