Compile Data Set for Download or QSAR
Report error Found 8 Enz. Inhib. hit(s) with all data for entry = 1602
TargetCoagulation factor X(Human)
Glaxosmithkline

LigandPNGBDBM12547(N-[(3S)-2-oxopyrrolidin-3-yl]sulfonamide, 1e | 6-c...)
Affinity DataKi:  15nM ΔG°:  -44.7kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2006
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Glaxosmithkline

LigandPNGBDBM12546(N-[(3S)-2-oxopyrrolidin-3-yl]sulfonamide, 1d | 5-c...)
Affinity DataKi:  47nM ΔG°:  -41.8kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2006
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Glaxosmithkline

LigandPNGBDBM12550(N-[(3S)-2-oxopyrrolidin-3-yl]sulfonamide, 1s | 5-c...)
Affinity DataKi:  90nM ΔG°:  -40.2kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2006
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Glaxosmithkline

LigandPNGBDBM12548(5-chloro-N-[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxop...)
Affinity DataKi:  112nM ΔG°:  -39.7kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2006
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Glaxosmithkline

LigandPNGBDBM12551(6-chloro-N-[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxop...)
Affinity DataKi:  170nM ΔG°:  -38.6kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2006
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Glaxosmithkline

LigandPNGBDBM12553(N-[(3S)-2-oxopyrrolidin-3-yl]sulfonamide, 1o | 6-c...)
Affinity DataKi:  285nM ΔG°:  -37.4kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2006
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Glaxosmithkline

LigandPNGBDBM12552(N-[(3S)-2-oxopyrrolidin-3-yl]sulfonamide, 1p | 5-c...)
Affinity DataKi:  782nM ΔG°:  -34.9kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2006
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Glaxosmithkline

LigandPNGBDBM12549(N-[(3S)-2-oxopyrrolidin-3-yl]sulfonamide, 1q | 6-c...)
Affinity DataKi:  4.16E+3nM ΔG°:  -30.7kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2006
Entry Details Article
PubMed