Compile Data Set for Download or QSAR
Report error Found 45 Enz. Inhib. hit(s) with all data for entry = 50018387
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50195200(3-(5-(piperidin-1-ylmethyl)-1H-indol-2-yl)-6-(1H-1...)
Affinity DataEC50:  230nMAssay Description:Release of camptothecin-induced cell cycle arrest in NCI-H1299 cells mediated by CHEK1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50195214(3-(5-(piperidin-1-ylmethyl)-1H-indol-2-yl)-6-(1H-p...)
Affinity DataEC50:  250nMAssay Description:Release of camptothecin-induced cell cycle arrest in NCI-H1299 cells mediated by CHEK1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50195217(3-(5-((4-acetylpiperazin-1-yl)methyl)-1H-indol-2-y...)
Affinity DataEC50:  420nMAssay Description:Release of camptothecin-induced cell cycle arrest in NCI-H1299 cells mediated by CHEK1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50195205(6-(2-methyl-2H-tetrazol-5-yl)-3-(5-(piperidin-1-yl...)
Affinity DataEC50:  1.30E+3nMAssay Description:Release of camptothecin-induced cell cycle arrest in NCI-H1299 cells mediated by CHEK1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50195199(6-(1H-imidazol-1-yl)-3-(5-(piperidin-1-ylmethyl)-1...)
Affinity DataEC50:  320nMAssay Description:Release of camptothecin-induced cell cycle arrest in NCI-H1299 cells mediated by CHEK1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50195196(3-(5-((4-(aminomethyl)piperidin-1-yl)methyl)-1H-in...)
Affinity DataEC50:  3.70E+3nMAssay Description:Release of camptothecin-induced cell cycle arrest in NCI-H1299 cells mediated by CHEK1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50195198(3-(5-((4-(aminomethyl)piperidin-1-yl)methyl)-1H-in...)
Affinity DataEC50:  3.90E+3nMAssay Description:Release of camptothecin-induced cell cycle arrest in NCI-H1299 cells mediated by CHEK1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50195212(6-bromo-3-(5-(piperidin-1-ylmethyl)-1H-indol-2-yl)...)
Affinity DataEC50:  460nMAssay Description:Release of camptothecin-induced cell cycle arrest in NCI-H1299 cells mediated by CHEK1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50195207(2-oxo-3-(5-(piperidin-1-ylmethyl)-1H-indol-2-yl)-1...)
Affinity DataEC50:  170nMAssay Description:Release of camptothecin-induced cell cycle arrest in NCI-H1299 cells mediated by CHEK1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50195201(3-(5-((4-acetylpiperazin-1-yl)methyl)-1H-indol-2-y...)
Affinity DataEC50:  870nMAssay Description:Release of camptothecin-induced cell cycle arrest in NCI-H1299 cells mediated by CHEK1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50195204(3-(5-((4-(2-methoxyacetyl)piperazin-1-yl)methyl)-1...)
Affinity DataEC50:  1.14E+3nMAssay Description:Release of camptothecin-induced cell cycle arrest in NCI-H1299 cells mediated by CHEK1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50195209(6-(1-methyl-1H-pyrazol-4-yl)-3-(5-(piperidin-1-ylm...)
Affinity DataEC50:  130nMAssay Description:Release of camptothecin-induced cell cycle arrest in NCI-H1299 cells mediated by CHEK1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50195211(2-oxo-3-(5-(piperidin-1-ylmethyl)-1H-indol-2-yl)-1...)
Affinity DataEC50:  520nMAssay Description:Release of camptothecin-induced cell cycle arrest in NCI-H1299 cells mediated by CHEK1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50195210(6-(4-hydroxy-3-methoxyphenyl)-3-(5-(piperidin-1-yl...)
Affinity DataEC50: >1.00E+4nMAssay Description:Release of camptothecin-induced cell cycle arrest in NCI-H1299 cells mediated by CHEK1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50195197(6-(isothiazol-4-yl)-3-(5-(piperidin-1-ylmethyl)-1H...)
Affinity DataEC50:  190nMAssay Description:Release of camptothecin-induced cell cycle arrest in NCI-H1299 cells mediated by CHEK1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50195202(3-(5-(piperidin-1-ylmethyl)-1H-indol-2-yl)-6-(2H-1...)
Affinity DataEC50:  880nMAssay Description:Release of camptothecin-induced cell cycle arrest in NCI-H1299 cells mediated by CHEK1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50195213(3-[5-(PIPERIDIN-1-YLMETHYL)-1H-INDOL-2-YL]-6-(1H-P...)
Affinity DataEC50:  97nMAssay Description:Release of camptothecin-induced cell cycle arrest in NCI-H1299 cells mediated by CHEK1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50195216(3-(5-((4-fluoropiperidin-1-yl)methyl)-1H-indol-2-y...)
Affinity DataEC50:  120nMAssay Description:Release of camptothecin-induced cell cycle arrest in NCI-H1299 cells mediated by CHEK1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50195218(3-(5-(morpholinomethyl)-1H-indol-2-yl)-6-(1H-pyraz...)
Affinity DataEC50:  170nMAssay Description:Release of camptothecin-induced cell cycle arrest in NCI-H1299 cells mediated by CHEK1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50195208(6-(3-hydroxyphenyl)-3-(5-(piperidin-1-ylmethyl)-1H...)
Affinity DataEC50:  6.30E+3nMAssay Description:Release of camptothecin-induced cell cycle arrest in NCI-H1299 cells mediated by CHEK1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50195211(2-oxo-3-(5-(piperidin-1-ylmethyl)-1H-indol-2-yl)-1...)
Affinity DataIC50: 0.340nMAssay Description:Inhibition of human CHEK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50195197(6-(isothiazol-4-yl)-3-(5-(piperidin-1-ylmethyl)-1H...)
Affinity DataIC50: 0.640nMAssay Description:Inhibition of human CHEK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50195213(3-[5-(PIPERIDIN-1-YLMETHYL)-1H-INDOL-2-YL]-6-(1H-P...)
Affinity DataIC50: 0.650nMAssay Description:Inhibition of human CHEK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50195198(3-(5-((4-(aminomethyl)piperidin-1-yl)methyl)-1H-in...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of human CHEK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50195200(3-(5-(piperidin-1-ylmethyl)-1H-indol-2-yl)-6-(1H-1...)
Affinity DataIC50: 0.740nMAssay Description:Inhibition of human CHEK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50195218(3-(5-(morpholinomethyl)-1H-indol-2-yl)-6-(1H-pyraz...)
Affinity DataIC50: 0.830nMAssay Description:Inhibition of human CHEK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50195216(3-(5-((4-fluoropiperidin-1-yl)methyl)-1H-indol-2-y...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human CHEK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50195209(6-(1-methyl-1H-pyrazol-4-yl)-3-(5-(piperidin-1-ylm...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human CHEK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50195204(3-(5-((4-(2-methoxyacetyl)piperazin-1-yl)methyl)-1...)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of human CHEK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50195201(3-(5-((4-acetylpiperazin-1-yl)methyl)-1H-indol-2-y...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human CHEK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50195212(6-bromo-3-(5-(piperidin-1-ylmethyl)-1H-indol-2-yl)...)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of human CHEK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50195217(3-(5-((4-acetylpiperazin-1-yl)methyl)-1H-indol-2-y...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human CHEK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50195196(3-(5-((4-(aminomethyl)piperidin-1-yl)methyl)-1H-in...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human CHEK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50195199(6-(1H-imidazol-1-yl)-3-(5-(piperidin-1-ylmethyl)-1...)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of human CHEK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50195207(2-oxo-3-(5-(piperidin-1-ylmethyl)-1H-indol-2-yl)-1...)
Affinity DataIC50: 4.60nMAssay Description:Inhibition of human CHEK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50195214(3-(5-(piperidin-1-ylmethyl)-1H-indol-2-yl)-6-(1H-p...)
Affinity DataIC50: 5.60nMAssay Description:Inhibition of human CHEK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50195205(6-(2-methyl-2H-tetrazol-5-yl)-3-(5-(piperidin-1-yl...)
Affinity DataIC50: 6.40nMAssay Description:Inhibition of human CHEK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50195215(3-(5-{[4-(AMINOMETHYL)PIPERIDIN-1-YL]METHYL}-1H-IN...)
Affinity DataIC50: 12nMAssay Description:Inhibition of human CHEK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50195202(3-(5-(piperidin-1-ylmethyl)-1H-indol-2-yl)-6-(2H-1...)
Affinity DataIC50: 14nMAssay Description:Inhibition of human CHEK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50195210(6-(4-hydroxy-3-methoxyphenyl)-3-(5-(piperidin-1-yl...)
Affinity DataIC50: 20nMAssay Description:Inhibition of human CHEK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50195208(6-(3-hydroxyphenyl)-3-(5-(piperidin-1-ylmethyl)-1H...)
Affinity DataIC50: 29nMAssay Description:Inhibition of human CHEK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50195206(3-(5-{[4-(AMINOMETHYL)PIPERIDIN-1-YL]METHYL}-1H-IN...)
Affinity DataIC50: 140nMAssay Description:Inhibition of human CHEK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50195203(3-(5-((4-(aminomethyl)piperidin-1-yl)methyl)-1H-in...)
Affinity DataIC50: 190nMAssay Description:Inhibition of human CHEK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50195219(3-(5-((4-(aminomethyl)piperidin-1-yl)methyl)-1H-in...)
Affinity DataIC50: 580nMAssay Description:Inhibition of human CHEK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM5328(3-(1H-indol-2-yl)-1,2-dihydroquinolin-2-one | CHEM...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human CHEK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed