Compile Data Set for Download or QSAR
Report error Found 16 Enz. Inhib. hit(s) with all data for entry = 423
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Merck Sharp and Dohme Research Laboratories

LigandPNGBDBM2223(2-Pyridinone derivative 21 | CHEMBL99235 | 3-[2-(4...)
Affinity DataIC50: 9.60nMpH: 8.2Assay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Merck Sharp and Dohme Research Laboratories

LigandPNGBDBM1317(3-{[(4,7-dichloro-1,3-benzoxazol-2-yl)methyl]amino...)
Affinity DataIC50: 19nMpH: 8.2Assay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Merck Sharp and Dohme Research Laboratories

LigandPNGBDBM1314(3-{[(4,7-dimethyl-1,3-benzoxazol-2-yl)methyl]amino...)
Affinity DataIC50: 20nMpH: 8.2Assay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Merck Sharp and Dohme Research Laboratories

LigandPNGBDBM2215(3-[2-(1,3-benzoxazol-2-yl)ethyl]-5-ethyl-6-methyl-...)
Affinity DataIC50: 22nMpH: 8.2Assay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Merck Sharp and Dohme Research Laboratories

LigandPNGBDBM2222(3-[2-(4,7-dimethyl-1,3-benzoxazol-2-yl)ethyl]-5-et...)
Affinity DataIC50: 23nMpH: 8.2Assay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Merck Sharp and Dohme Research Laboratories

LigandPNGBDBM1057(3-[N-(Phthalimidomethyl)amino]-5-ethyl-6-methylpyr...)
Affinity DataIC50: 30nMpH: 8.2Assay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Merck Sharp and Dohme Research Laboratories

LigandPNGBDBM1312(Pyridinone deriv. 12 | 5-ethyl-6-methyl-3-{[(7-met...)
Affinity DataIC50: 55nMpH: 8.2Assay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Merck Sharp and Dohme Research Laboratories

LigandPNGBDBM2217(2-Pyridinone derivative 12 | CHEMBL98159 | 3-[2-(1...)
Affinity DataIC50: 77nMpH: 8.2Assay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Merck Sharp and Dohme Research Laboratories

LigandPNGBDBM1309(Pyridinone deriv. 11 | 5-ethyl-6-methyl-3-{[(4-met...)
Affinity DataIC50: 125nMpH: 8.2Assay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Merck Sharp and Dohme Research Laboratories

LigandPNGBDBM1283(3-{[1,3-benzoxazol-2-yl)-methyl]amino}-5-ethyl-6-m...)
Affinity DataIC50: 210nMpH: 8.2Assay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Merck Sharp and Dohme Research Laboratories

LigandPNGBDBM1284(CHEMBL316785 | Pyridinone deriv. 8 | 3-[(1-benzofu...)
Affinity DataIC50: 235nMpH: 8.2Assay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Merck Sharp and Dohme Research Laboratories

LigandPNGBDBM1287(3-[(1,3-benzothiazol-2-ylmethyl)amino]-5-ethyl-6-m...)
Affinity DataIC50: 350nMpH: 8.2Assay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Merck Sharp and Dohme Research Laboratories

LigandPNGBDBM2213(3-[2-(1,3-benzothiazol-2-yl)ethyl]-5-ethyl-6-methy...)
Affinity DataIC50: 370nMpH: 8.2Assay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Merck Sharp and Dohme Research Laboratories

LigandPNGBDBM1288(Pyridinone deriv. 10 | 5-ethyl-6-methyl-3-[(naphth...)
Affinity DataIC50: 440nMpH: 8.2Assay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Merck Sharp and Dohme Research Laboratories

LigandPNGBDBM1066(2-[2-(5-ethyl-6-methyl-2-oxo-1,2-dihydropyridin-3-...)
Affinity DataIC50: 3.70E+3nMpH: 8.2Assay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Merck Sharp and Dohme Research Laboratories

LigandPNGBDBM1299(CHEMBL98394 | 3-[(1H-1,3-benzodiazol-2-ylmethyl)am...)
Affinity DataIC50: 6.40E+3nMpH: 8.2Assay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2004
Entry Details Article
PubMed