Compile Data Set for Download or QSAR
Report error Found 26 Enz. Inhib. hit(s) with all data for entry = 1866
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))
University of Leeds

LigandPNGBDBM14710(ChemBridge compound no. 2 | N-(4-Bromo-2-methylphe...)
Affinity DataKi:  20nM ΔG°:  -43.9kJ/mole IC50: 180nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2007
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))
University of Leeds

LigandPNGBDBM14699(1,3-diethyl 2-({8-thiatricyclo[7.4.0.0^{2,7}]tride...)
Affinity DataKi:  20nM ΔG°:  -43.9kJ/mole IC50: 160nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2007
Entry Details Article
PubMed
LigandPNGBDBM14712(A77 1726 | CHEMBL973 | (2Z)-2-cyano-3-hydroxy-N-[4...)
Affinity DataKi:  30nM IC50: 260nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2007
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))
University of Leeds

LigandPNGBDBM14711(Asinex compound no. 6 | N-(3,5-Dichlorophenyl)-2-m...)
Affinity DataKi:  30nM ΔG°:  -42.9kJ/mole IC50: 230nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))
University of Leeds

LigandPNGBDBM14701(ethyl (2Z)-2-cyano-3-[(9-ethyl-9H-carbazol-3-yl)am...)
Affinity DataKi:  50nM ΔG°:  -41.7kJ/mole IC50: 440nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2007
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))
University of Leeds

LigandPNGBDBM14708(Ethyl 3-(biphenyl-3-ylamino)-2-cyanoacrylate | eth...)
Affinity DataKi:  2.45E+3nM ΔG°:  -32.0kJ/mole IC50: 2.13E+4nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2007
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))
University of Leeds

LigandPNGBDBM14702(1,3-diethyl 2-[(1H-indazol-5-ylamino)methylidene]p...)
Affinity DataKi:  3.20E+3nM ΔG°:  -31.4kJ/mole IC50: 2.78E+4nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2007
Entry Details Article
PubMed
LigandPNGBDBM14699(1,3-diethyl 2-({8-thiatricyclo[7.4.0.0^{2,7}]tride...)
Affinity DataKi:  3.63E+3nM IC50: 2.96E+4nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2007
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))
University of Leeds

LigandPNGBDBM14703(2-(p-Tolylamino-methylene)-malonic acid diethyl es...)
Affinity DataKi:  4.60E+3nM ΔG°:  -30.5kJ/mole IC50: 4.00E+4nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2007
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))
University of Leeds

LigandPNGBDBM14709(Diethyl 2-((biphenyl-3-ylamino)methylene)malonate ...)
Affinity DataKi:  1.00E+4nM ΔG°:  -28.5kJ/mole IC50: 8.67E+4nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2007
Entry Details Article
PubMed
LigandPNGBDBM14709(Diethyl 2-((biphenyl-3-ylamino)methylene)malonate ...)
Affinity DataKi:  1.28E+4nM IC50: 1.04E+5nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2007
Entry Details Article
PubMed
LigandPNGBDBM14702(1,3-diethyl 2-[(1H-indazol-5-ylamino)methylidene]p...)
Affinity DataKi:  1.51E+4nM IC50: 1.23E+5nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2007
Entry Details Article
PubMed
LigandPNGBDBM14703(2-(p-Tolylamino-methylene)-malonic acid diethyl es...)
Affinity DataKi:  1.79E+4nM IC50: 1.46E+5nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2007
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))
University of Leeds

LigandPNGBDBM14712(A77 1726 | CHEMBL973 | (2Z)-2-cyano-3-hydroxy-N-[4...)
Affinity DataKi:  2.34E+4nM ΔG°:  -26.4kJ/mole IC50: 1.90E+5nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2007
Entry Details Article
PubMed
LigandPNGBDBM14708(Ethyl 3-(biphenyl-3-ylamino)-2-cyanoacrylate | eth...)
Affinity DataKi:  2.70E+4nM IC50: 2.20E+5nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2007
Entry Details Article
PubMed
LigandPNGBDBM14704(1,3-diethyl 2-{[(2-methylphenyl)amino]methylidene}...)
Affinity DataKi:  3.59E+4nM IC50: 2.92E+5nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2007
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))
University of Leeds

LigandPNGBDBM14704(1,3-diethyl 2-{[(2-methylphenyl)amino]methylidene}...)
Affinity DataKi:  3.97E+4nM ΔG°:  -25.1kJ/mole IC50: 3.46E+5nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2007
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))
University of Leeds

LigandPNGBDBM14705(1,3-diethyl 2-[(1H-1,3-benzodiazol-5-ylamino)methy...)
Affinity DataKi:  4.02E+4nM ΔG°:  -25.1kJ/mole IC50: 3.49E+5nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2007
Entry Details Article
PubMed
LigandPNGBDBM14710(ChemBridge compound no. 2 | N-(4-Bromo-2-methylphe...)
Affinity DataKi:  5.09E+4nM IC50: 4.15E+5nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2007
Entry Details Article
PubMed
LigandPNGBDBM14701(ethyl (2Z)-2-cyano-3-[(9-ethyl-9H-carbazol-3-yl)am...)
Affinity DataKi:  6.04E+4nM IC50: 4.91E+5nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2007
Entry Details Article
PubMed
LigandPNGBDBM14711(Asinex compound no. 6 | N-(3,5-Dichlorophenyl)-2-m...)
Affinity DataKi:  6.44E+4nM IC50: 5.24E+5nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2007
Entry Details Article
PubMed
LigandPNGBDBM14705(1,3-diethyl 2-[(1H-1,3-benzodiazol-5-ylamino)methy...)
Affinity DataIC50: 5.00E+5nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2007
Entry Details Article
PubMed
LigandPNGBDBM14706(ethyl (2Z)-2-cyano-3-[(4-phenylphenyl)amino]prop-2...)
Affinity DataIC50: 5.00E+5nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2007
Entry Details Article
PubMed
LigandPNGBDBM14707(1,3-diethyl 2-{[(4-phenylphenyl)amino]methylidene}...)
Affinity DataIC50: 5.00E+5nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2007
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))
University of Leeds

LigandPNGBDBM14706(ethyl (2Z)-2-cyano-3-[(4-phenylphenyl)amino]prop-2...)
Affinity DataIC50: 5.00E+5nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2007
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))
University of Leeds

LigandPNGBDBM14707(1,3-diethyl 2-{[(4-phenylphenyl)amino]methylidene}...)
Affinity DataIC50: 5.00E+5nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2007
Entry Details Article
PubMed