Compile Data Set for Download or QSAR
Report error Found 24 Enz. Inhib. hit(s) with all data for entry = 2991
TargetSerine/threonine-protein kinase pim-1(Human)
Valeant Pharmaceuticals Research and Development

LigandPNGBDBM26673(CHEMBL391586 | 6-(5-bromo-2-hydroxyphenyl)-2-oxo-4...)
Affinity DataIC50: 50nMpH: 7.5 T: 2°CAssay Description:PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase pim-1(Human)
Valeant Pharmaceuticals Research and Development

LigandPNGBDBM26674(6-(2-hydroxy-5-methylphenyl)-2-oxo-4-phenyl-1,2-di...)
Affinity DataIC50: 340nMpH: 7.5 T: 2°CAssay Description:PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Valeant Pharmaceuticals Research and Development

LigandPNGBDBM26675(4-(2-hydroxy-5-methylphenyl)-2-oxo-6-phenyl-1,2-di...)
Affinity DataIC50: 370nMpH: 7.5 T: 2°CAssay Description:PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Valeant Pharmaceuticals Research and Development

LigandPNGBDBM26676(6-(2-hydroxyphenyl)-4-(4-hydroxyphenyl)-2-oxo-1,2-...)
Affinity DataIC50: 430nMpH: 7.5 T: 2°CAssay Description:PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Valeant Pharmaceuticals Research and Development

LigandPNGBDBM26684(4-oxo-6-(thiophen-2-yl)-9-oxa-3-azatricyclo[8.4.0....)
Affinity DataIC50: 460nMpH: 7.5 T: 2°CAssay Description:PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Valeant Pharmaceuticals Research and Development

LigandPNGBDBM26685(6-(furan-2-yl)-4-oxo-9-oxa-3-azatricyclo[8.4.0.0^{...)
Affinity DataIC50: 870nMpH: 7.5 T: 2°CAssay Description:PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Valeant Pharmaceuticals Research and Development

LigandPNGBDBM26686(cid_399090 | 6-(4-chlorophenyl)-4-oxo-9-oxa-3-azat...)
Affinity DataIC50: 920nMpH: 7.5 T: 2°CAssay Description:PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Valeant Pharmaceuticals Research and Development

LigandPNGBDBM26679(2-oxo-4,6-bis(thiophen-2-yl)-1,2-dihydropyridine-3...)
Affinity DataIC50: 990nMpH: 7.5 T: 2°CAssay Description:PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Valeant Pharmaceuticals Research and Development

LigandPNGBDBM26677(4-(3-chlorophenyl)-6-(5-ethyl-2-hydroxyphenyl)-2-o...)
Affinity DataIC50: 1.03E+3nMpH: 7.5 T: 2°CAssay Description:PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Valeant Pharmaceuticals Research and Development

LigandPNGBDBM26678(6-(3-bromo-4-methoxyphenyl)-2-oxo-4-(trifluorometh...)
Affinity DataIC50: 1.14E+3nMpH: 7.5 T: 2°CAssay Description:PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Valeant Pharmaceuticals Research and Development

LigandPNGBDBM26687(6-(2-chlorophenyl)-4-oxo-9-oxa-3-azatricyclo[8.4.0...)
Affinity DataIC50: 1.23E+3nMpH: 7.5 T: 2°CAssay Description:PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Valeant Pharmaceuticals Research and Development

LigandPNGBDBM26691(4-oxo-6-(thiophen-2-yl)-9-thia-3-azatricyclo[8.4.0...)
Affinity DataIC50: 1.49E+3nMpH: 7.5 T: 2°CAssay Description:PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Valeant Pharmaceuticals Research and Development

LigandPNGBDBM26683(2-{3-amino-4-phenyl-1H-pyrazolo[3,4-b]pyridin-6-yl...)
Affinity DataIC50: 1.77E+3nMpH: 7.5 T: 2°CAssay Description:PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Valeant Pharmaceuticals Research and Development

LigandPNGBDBM26680(2-oxo-4-(thiophen-2-yl)-6-(trifluoromethyl)-1,2-di...)
Affinity DataIC50: 3.54E+3nMpH: 7.5 T: 2°CAssay Description:PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Valeant Pharmaceuticals Research and Development

LigandPNGBDBM26682(2-amino-6-(4-hydroxyphenyl)-4-phenylpyridine-3-car...)
Affinity DataIC50: 4.41E+3nMpH: 7.5 T: 2°CAssay Description:PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Valeant Pharmaceuticals Research and Development

LigandPNGBDBM26692(4-oxo-6-(pyridin-3-yl)-9-thia-3-azatricyclo[8.4.0....)
Affinity DataIC50: 4.79E+3nMpH: 7.5 T: 2°CAssay Description:PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Valeant Pharmaceuticals Research and Development

LigandPNGBDBM26681(6-(furan-2-yl)-2-oxo-4-(trifluoromethyl)-1,2-dihyd...)
Affinity DataIC50: 1.60E+4nMpH: 7.5 T: 2°CAssay Description:PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Valeant Pharmaceuticals Research and Development

LigandPNGBDBM26696(ethyl 3-methyl-4,8-dioxo-9-oxa-3-azatricyclo[8.4.0...)
Affinity DataIC50: 2.00E+4nMpH: 7.5 T: 2°CAssay Description:PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Valeant Pharmaceuticals Research and Development

LigandPNGBDBM26695(4-oxo-6-(pyridin-4-yl)-3-azatricyclo[8.4.0.0^{2,7}...)
Affinity DataIC50: 2.00E+4nMpH: 7.5 T: 2°CAssay Description:PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Valeant Pharmaceuticals Research and Development

LigandPNGBDBM26694(6-(4-fluorophenyl)-4-oxo-9-thia-3-azatricyclo[8.4....)
Affinity DataIC50: 2.00E+4nMpH: 7.5 T: 2°CAssay Description:PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Valeant Pharmaceuticals Research and Development

LigandPNGBDBM26693(6-(2-chlorophenyl)-4-oxo-9-thia-3-azatricyclo[8.4....)
Affinity DataIC50: 2.00E+4nMpH: 7.5 T: 2°CAssay Description:PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Valeant Pharmaceuticals Research and Development

LigandPNGBDBM26690(4-oxo-6-(pyridin-2-yl)-9-oxa-3-azatricyclo[8.4.0.0...)
Affinity DataIC50: 2.00E+4nMpH: 7.5 T: 2°CAssay Description:PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Valeant Pharmaceuticals Research and Development

LigandPNGBDBM26689(2-keto-4-(4-pyridyl)-1,5-dihydrochromeno[4,3-b]pyr...)
Affinity DataIC50: 2.00E+4nMpH: 7.5 T: 2°CAssay Description:PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Valeant Pharmaceuticals Research and Development

LigandPNGBDBM26688(6-(4-methoxyphenyl)-4-oxo-9-oxa-3-azatricyclo[8.4....)
Affinity DataIC50: 2.00E+4nMpH: 7.5 T: 2°CAssay Description:PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2009
Entry Details Article
PubMed