Compile Data Set for Download or QSAR
Report error Found 59 Enz. Inhib. hit(s) with all data for entry = 50019801
TargetAngiopoietin-1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50207856(3-isopropyl-N-(4-methyl-3-(3-(2-(methylamino)pyrid...)
Affinity DataIC50: 1nMAssay Description:Inhibition of Tie2 after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50207855(N-(3-isopropylphenyl)-4-methyl-3-(3-(4-(methylamin...)
Affinity DataIC50: 1nMAssay Description:Inhibition of Tie2 after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM14974(N-{3-[3-(dimethylamino)propyl]-5-(trifluoromethyl)...)
Affinity DataIC50: 1nMAssay Description:Inhibition of Tie2 after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50207852(3-isopropyl-N-(4-methyl-3-(3-(4-(methylamino)-1,3,...)
Affinity DataIC50: 1nMAssay Description:Inhibition of Tie2 after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50207850(3-isopropyl-N-(4-methyl-3-(3-(2-(methylamino)pyrim...)
Affinity DataIC50: 2nMAssay Description:Inhibition of Tie2 after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM14974(N-{3-[3-(dimethylamino)propyl]-5-(trifluoromethyl)...)
Affinity DataIC50: 2nMAssay Description:Inhibition of KDR after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50207850(3-isopropyl-N-(4-methyl-3-(3-(2-(methylamino)pyrim...)
Affinity DataIC50: 2nMAssay Description:Inhibition of KDR after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50207859(N-(3-isopropylphenyl)-4-methyl-3-(3-(2-(methylamin...)
Affinity DataIC50: 3nMAssay Description:Inhibition of Tie2 after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50207862(3-isopropyl-N-(3-(3-(2-(methylamino)pyridin-4-yl)p...)
Affinity DataIC50: 4nMAssay Description:Inhibition of Tie2 after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50207858(N-(4-fluoro-3-(3-(4-(methylamino)-1,3,5-triazin-2-...)
Affinity DataIC50: 4nMAssay Description:Inhibition of Tie2 after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50207859(N-(3-isopropylphenyl)-4-methyl-3-(3-(2-(methylamin...)
Affinity DataIC50: 5nMAssay Description:Inhibition of KDR after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50207852(3-isopropyl-N-(4-methyl-3-(3-(4-(methylamino)-1,3,...)
Affinity DataIC50: 5nMAssay Description:Inhibition of Tie2 autophosphorylation in EA.hy926 cells after 2.5 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50207853(3-isopropyl-N-(3-(3-(4-(methylamino)-1,3,5-triazin...)
Affinity DataIC50: 6nMAssay Description:Inhibition of Tie2 after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50207849(N-(2-chloro-5-(3-(2-(methylamino)pyridin-4-yl)pyri...)
Affinity DataIC50: 6nMAssay Description:Inhibition of Tie2 after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50207848(N-(4-methyl-3-(3-(4-(methylamino)-1,3,5-triazin-2-...)
Affinity DataIC50: 8nMAssay Description:Inhibition of Tie2 after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50207857(N-(4-methyl-3-(3-(2-(methylamino)pyridin-4-yl)pyri...)
Affinity DataIC50: 9nMAssay Description:Inhibition of Tie2 after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50207849(N-(2-chloro-5-(3-(2-(methylamino)pyridin-4-yl)pyri...)
Affinity DataIC50: 9nMAssay Description:Inhibition of KDR after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50207856(3-isopropyl-N-(4-methyl-3-(3-(2-(methylamino)pyrid...)
Affinity DataIC50: 11nMAssay Description:Inhibition of Tie2 autophosphorylation in EA.hy926 cells after 2.5 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50207847(N-(3-isopropylphenyl)-4-methyl-3-(3-(2-(methylamin...)
Affinity DataIC50: 13nMAssay Description:Inhibition of Tie2 after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50207857(N-(4-methyl-3-(3-(2-(methylamino)pyridin-4-yl)pyri...)
Affinity DataIC50: 13nMAssay Description:Inhibition of Tie2 autophosphorylation in EA.hy926 cells after 2.5 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50207848(N-(4-methyl-3-(3-(4-(methylamino)-1,3,5-triazin-2-...)
Affinity DataIC50: 15nMAssay Description:Inhibition of Tie2 autophosphorylation in EA.hy926 cells after 2.5 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50207854(N-(4-methyl-3-(3-(4-(methylamino)-1,3,5-triazin-2-...)
Affinity DataIC50: 16nMAssay Description:Inhibition of Tie2 after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50207851(N-(4-methyl-3-(3-(4-(methylamino)-1,3,5-triazin-2-...)
Affinity DataIC50: 17nMAssay Description:Inhibition of Tie2 after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50207861(N-(4-methyl-3-(3-(pyrimidin-4-yl)pyridin-2-ylamino...)
Affinity DataIC50: 17nMAssay Description:Inhibition of Tie2 after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50207862(3-isopropyl-N-(3-(3-(2-(methylamino)pyridin-4-yl)p...)
Affinity DataIC50: 18nMAssay Description:Inhibition of KDR after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50207856(3-isopropyl-N-(4-methyl-3-(3-(2-(methylamino)pyrid...)
Affinity DataIC50: 18nMAssay Description:Inhibition of KDR after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50207855(N-(3-isopropylphenyl)-4-methyl-3-(3-(4-(methylamin...)
Affinity DataIC50: 20nMAssay Description:Inhibition of KDR after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50207860(N-(4-methyl-3-(3-(4-(methylamino)-1,3,5-triazin-2-...)
Affinity DataIC50: 20nMAssay Description:Inhibition of Tie2 after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50207851(N-(4-methyl-3-(3-(4-(methylamino)-1,3,5-triazin-2-...)
Affinity DataIC50: 23nMAssay Description:Inhibition of Tie2 autophosphorylation in EA.hy926 cells after 2.5 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50207854(N-(4-methyl-3-(3-(4-(methylamino)-1,3,5-triazin-2-...)
Affinity DataIC50: 33nMAssay Description:Inhibition of Tie2 autophosphorylation in EA.hy926 cells after 2.5 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50207847(N-(3-isopropylphenyl)-4-methyl-3-(3-(2-(methylamin...)
Affinity DataIC50: 38nMAssay Description:Inhibition of KDR after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50207854(N-(4-methyl-3-(3-(4-(methylamino)-1,3,5-triazin-2-...)
Affinity DataIC50: 47nMAssay Description:Inhibition of p38-alpha by radioactive filtration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50207863(3-isopropyl-N-(3-(3-(4-(methylamino)-1,3,5-triazin...)
Affinity DataIC50: 55nMAssay Description:Inhibition of Tie2 after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50207861(N-(4-methyl-3-(3-(pyrimidin-4-yl)pyridin-2-ylamino...)
Affinity DataIC50: 61nMAssay Description:Inhibition of KDR after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50207853(3-isopropyl-N-(3-(3-(4-(methylamino)-1,3,5-triazin...)
Affinity DataIC50: 85nMAssay Description:Inhibition of Tie2 autophosphorylation in EA.hy926 cells after 2.5 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50207852(3-isopropyl-N-(4-methyl-3-(3-(4-(methylamino)-1,3,...)
Affinity DataIC50: 117nMAssay Description:Inhibition of KDR after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50207858(N-(4-fluoro-3-(3-(4-(methylamino)-1,3,5-triazin-2-...)
Affinity DataIC50: 128nMAssay Description:Inhibition of KDR after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50207854(N-(4-methyl-3-(3-(4-(methylamino)-1,3,5-triazin-2-...)
Affinity DataIC50: 146nMAssay Description:Inhibition of Lck by radioactive filtration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50207854(N-(4-methyl-3-(3-(4-(methylamino)-1,3,5-triazin-2-...)
Affinity DataIC50: 194nMAssay Description:Inhibition of p38-alpha in THP1 cells assessed as TNFalpha levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50207857(N-(4-methyl-3-(3-(2-(methylamino)pyridin-4-yl)pyri...)
Affinity DataIC50: 233nMAssay Description:Inhibition of KDR after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50207860(N-(4-methyl-3-(3-(4-(methylamino)-1,3,5-triazin-2-...)
Affinity DataIC50: 309nMAssay Description:Inhibition of KDR after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50207848(N-(4-methyl-3-(3-(4-(methylamino)-1,3,5-triazin-2-...)
Affinity DataIC50: 442nMAssay Description:Inhibition of KDR after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50207853(3-isopropyl-N-(3-(3-(4-(methylamino)-1,3,5-triazin...)
Affinity DataIC50: 456nMAssay Description:Inhibition of KDR after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50207848(N-(4-methyl-3-(3-(4-(methylamino)-1,3,5-triazin-2-...)
Affinity DataIC50: 540nMAssay Description:Inhibition of KDR autophosphorylation in EA.hy926 cells after 2.5 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50207857(N-(4-methyl-3-(3-(2-(methylamino)pyridin-4-yl)pyri...)
Affinity DataIC50: 943nMAssay Description:Inhibition of KDR autophosphorylation in EA.hy926 cells after 2.5 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50207854(N-(4-methyl-3-(3-(4-(methylamino)-1,3,5-triazin-2-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of KDR after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50207851(N-(4-methyl-3-(3-(4-(methylamino)-1,3,5-triazin-2-...)
Affinity DataIC50: 1.13E+3nMAssay Description:Inhibition of KDR after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50207854(N-(4-methyl-3-(3-(4-(methylamino)-1,3,5-triazin-2-...)
Affinity DataIC50: 1.75E+3nMAssay Description:Inhibition of Jak2 by radioactive filtration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50207854(N-(4-methyl-3-(3-(4-(methylamino)-1,3,5-triazin-2-...)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of Src by radioactive filtration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50207854(N-(4-methyl-3-(3-(4-(methylamino)-1,3,5-triazin-2-...)
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of KDR autophosphorylation in EA.hy926 cells after 2.5 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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