Compile Data Set for Download or QSAR
Report error Found 45 Enz. Inhib. hit(s) with all data for entry = 50019990
TargetATP-dependent translocase ABCB1(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50209508(N-(2-(4-(4-(3,4-dimethoxybenzyl)piperazin-1-yl)phe...)
Affinity DataEC50:  59nMAssay Description:Reversal of P-gp-mediated multidrug resistance to vinblastine in human CEM/VLB500 cells after 3 days by resazurin assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50075373(CHEMBL348475 | 1N-{4-[2-(6,7-dimethoxy-1,2,3,4-tet...)
Affinity DataEC50:  68nMAssay Description:Reversal of P-gp-mediated multidrug resistance to vinblastine in human CEM/VLB500 cells after 3 days by resazurin assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCytochrome P450 2C9(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50209508(N-(2-(4-(4-(3,4-dimethoxybenzyl)piperazin-1-yl)phe...)
Affinity DataIC50: 97nMAssay Description:Inhibition of human CYP2C9 expressed in insect microsome after 45 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50209506(N-(2-(4-(4-(3,4-dimethoxybenzyl)piperazin-1-yl)phe...)
Affinity DataEC50:  124nMAssay Description:Reversal of P-gp-mediated multidrug resistance to vinblastine in human CEM/VLB500 cells after 3 days by resazurin assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50209508(N-(2-(4-(4-(3,4-dimethoxybenzyl)piperazin-1-yl)phe...)
Affinity DataIC50: 195nMAssay Description:Inhibition of human CYP3A4 expressed in insect microsome using 7-benzyloxy-4-trifluoromethylcoumarin substrate after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50209510((S) N-(2-((1-(3,4-dimethoxyphenethyl)pyrrolidin-2-...)
Affinity DataEC50:  329nMAssay Description:Reversal of P-gp-mediated multidrug resistance to vinblastine in human CEM/VLB500 cells after 3 days by resazurin assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50209508(N-(2-(4-(4-(3,4-dimethoxybenzyl)piperazin-1-yl)phe...)
Affinity DataIC50: 393nMAssay Description:Inhibition of human CYP2C19 expressed in insect microsome after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50209507((R) N-(2-((1-(3,4-dimethoxyphenethyl)pyrrolidin-2-...)
Affinity DataEC50:  482nMAssay Description:Reversal of P-gp-mediated multidrug resistance to vinblastine in human CEM/VLB500 cells after 3 days by resazurin assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50209509(rac-cis-N-(2-(2-(4-phenylpiperazin-1-yl)cyclohexyl...)
Affinity DataEC50:  648nMAssay Description:Reversal of P-gp-mediated multidrug resistance to vinblastine in human CEM/VLB500 cells after 3 days by resazurin assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Université

Curated by ChEMBL
LigandPNGBDBM81939(NSC_62969 | VERAPAMIL | CAS_52-53-9)
Affinity DataEC50:  1.04E+3nMAssay Description:Reversal of P-gp-mediated multidrug resistance to vinblastine in human CEM/VLB500 cells after 3 days by resazurin assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50209508(N-(2-(4-(4-(3,4-dimethoxybenzyl)piperazin-1-yl)phe...)
Affinity DataIC50: 1.08E+3nMAssay Description:Inhibition of human CYP2C8 expressed in insect microsome after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50209505(N-(2-((2-((3,4-dimethoxyphenethyl)(methyl)amino)et...)
Affinity DataIC50: 1.62E+3nMAssay Description:Inhibition of human CYP3A4 expressed in insect microsome using 7-benzyloxy-4-trifluoromethylcoumarin substrate after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50209505(N-(2-((2-((3,4-dimethoxyphenethyl)(methyl)amino)et...)
Affinity DataIC50: 2.08E+3nMAssay Description:Inhibition of human CYP2C9 expressed in insect microsome after 45 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50209508(N-(2-(4-(4-(3,4-dimethoxybenzyl)piperazin-1-yl)phe...)
Affinity DataIC50: 2.48E+3nMAssay Description:Inhibition of human CYP2E1 expressed in insect microsome using 7-benzyloxyquinoline substrate after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50209506(N-(2-(4-(4-(3,4-dimethoxybenzyl)piperazin-1-yl)phe...)
Affinity DataIC50: 3.58E+3nMAssay Description:Inhibition of human CYP2E1 expressed in insect microsome using 7-benzyloxyquinoline substrate after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50209505(N-(2-((2-((3,4-dimethoxyphenethyl)(methyl)amino)et...)
Affinity DataIC50: 5.82E+3nMAssay Description:Inhibition of human CYP2C8 expressed in insect microsome after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50209508(N-(2-(4-(4-(3,4-dimethoxybenzyl)piperazin-1-yl)phe...)
Affinity DataIC50: 6.68E+3nMAssay Description:Inhibition of human CYP1A2 expressed in insect microsome after 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50075373(CHEMBL348475 | 1N-{4-[2-(6,7-dimethoxy-1,2,3,4-tet...)
Affinity DataIC50: 7.10E+3nMAssay Description:Inhibition of human CYP2C9 expressed in insect microsome after 45 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50209505(N-(2-((2-((3,4-dimethoxyphenethyl)(methyl)amino)et...)
Affinity DataIC50: 7.75E+3nMAssay Description:Inhibition of human CYP2E1 expressed in insect microsome using 7-benzyloxyquinoline substrate after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50075373(CHEMBL348475 | 1N-{4-[2-(6,7-dimethoxy-1,2,3,4-tet...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP2C19 expressed in insect microsome after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50209506(N-(2-(4-(4-(3,4-dimethoxybenzyl)piperazin-1-yl)phe...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP2C9 expressed in insect microsome after 45 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50209506(N-(2-(4-(4-(3,4-dimethoxybenzyl)piperazin-1-yl)phe...)
Affinity DataIC50: 1.33E+4nMAssay Description:Inhibition of human CYP2C8 expressed in insect microsome after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50209505(N-(2-((2-((3,4-dimethoxyphenethyl)(methyl)amino)et...)
Affinity DataIC50: 1.47E+4nMAssay Description:Inhibition of human CYP2C19 expressed in insect microsome after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50209508(N-(2-(4-(4-(3,4-dimethoxybenzyl)piperazin-1-yl)phe...)
Affinity DataIC50: 1.73E+4nMAssay Description:Inhibition of human CYP2D6 expressed in insect microsome after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50209506(N-(2-(4-(4-(3,4-dimethoxybenzyl)piperazin-1-yl)phe...)
Affinity DataIC50: 2.02E+4nMAssay Description:Inhibition of human CYP3A4 expressed in insect microsome using 7-benzyloxy-4-trifluoromethylcoumarin substrate after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50209506(N-(2-(4-(4-(3,4-dimethoxybenzyl)piperazin-1-yl)phe...)
Affinity DataIC50: 2.30E+4nMAssay Description:Inhibition of human CYP2C19 expressed in insect microsome after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50075373(CHEMBL348475 | 1N-{4-[2-(6,7-dimethoxy-1,2,3,4-tet...)
Affinity DataIC50: 2.72E+4nMAssay Description:Inhibition of human CYP1A2 expressed in insect microsome after 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50075373(CHEMBL348475 | 1N-{4-[2-(6,7-dimethoxy-1,2,3,4-tet...)
Affinity DataIC50: 4.53E+4nMAssay Description:Inhibition of human CYP2C8 expressed in insect microsome after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50075373(CHEMBL348475 | 1N-{4-[2-(6,7-dimethoxy-1,2,3,4-tet...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human CYP3A4 expressed in insect microsome using 7-benzyloxy-4-trifluoromethylcoumarin substrate after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2A6(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50209506(N-(2-(4-(4-(3,4-dimethoxybenzyl)piperazin-1-yl)phe...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human CYP2A6 expressed in insect microsome after 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2E1(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50209505(N-(2-((2-((3,4-dimethoxyphenethyl)(methyl)amino)et...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human CYP2E1 expressed in insect microsome after 45 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50075373(CHEMBL348475 | 1N-{4-[2-(6,7-dimethoxy-1,2,3,4-tet...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human CYP2E1 expressed in insect microsome using 7-benzyloxyquinoline substrate after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50209506(N-(2-(4-(4-(3,4-dimethoxybenzyl)piperazin-1-yl)phe...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human CYP2D6 expressed in insect microsome after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2A6(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50075373(CHEMBL348475 | 1N-{4-[2-(6,7-dimethoxy-1,2,3,4-tet...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human CYP2A6 expressed in insect microsome after 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50209508(N-(2-(4-(4-(3,4-dimethoxybenzyl)piperazin-1-yl)phe...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human CYP2B6 expressed in insect microsome after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50209506(N-(2-(4-(4-(3,4-dimethoxybenzyl)piperazin-1-yl)phe...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human CYP2B6 expressed in insect microsome after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2A6(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50209505(N-(2-((2-((3,4-dimethoxyphenethyl)(methyl)amino)et...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human CYP2A6 expressed in insect microsome after 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50209506(N-(2-(4-(4-(3,4-dimethoxybenzyl)piperazin-1-yl)phe...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human CYP1A2 expressed in insect microsome after 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50075373(CHEMBL348475 | 1N-{4-[2-(6,7-dimethoxy-1,2,3,4-tet...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human CYP2D6 expressed in insect microsome after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2E1(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50209506(N-(2-(4-(4-(3,4-dimethoxybenzyl)piperazin-1-yl)phe...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human CYP2E1 expressed in insect microsome after 45 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50075373(CHEMBL348475 | 1N-{4-[2-(6,7-dimethoxy-1,2,3,4-tet...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human CYP2B6 expressed in insect microsome after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50209505(N-(2-((2-((3,4-dimethoxyphenethyl)(methyl)amino)et...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human CYP1A2 expressed in insect microsome after 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2E1(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50075373(CHEMBL348475 | 1N-{4-[2-(6,7-dimethoxy-1,2,3,4-tet...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human CYP2E1 expressed in insect microsome after 45 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50209505(N-(2-((2-((3,4-dimethoxyphenethyl)(methyl)amino)et...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human CYP2D6 expressed in insect microsome after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50209505(N-(2-((2-((3,4-dimethoxyphenethyl)(methyl)amino)et...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human CYP2B6 expressed in insect microsome after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed