Compile Data Set for Download or QSAR
Report error Found 19 Enz. Inhib. hit(s) with all data for entry = 3520
TargetCannabinoid receptor 1(Human)
Astrazeneca

LigandPNGBDBM35870(5,6-bis-(4-bromo-phenyl)-pyrazine-2-carboxylicacid...)
Affinity DataIC50: 1nMpH: 7.4 T: 2°CAssay Description:A GTP-gamma-S CB1 functional assay was used to assess the potency of the pyrazine derivatives. [35S]GTP-gamma-S binding assays were performed at 30 d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2009
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Astrazeneca

LigandPNGBDBM21278(SR141716 | 5-(4-chlorophenyl)-1-(2,4-dichloropheny...)
Affinity DataIC50: 3nMpH: 7.4 T: 2°CAssay Description:A GTP-gamma-S CB1 functional assay was used to assess the potency of the pyrazine derivatives. [35S]GTP-gamma-S binding assays were performed at 30 d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2009
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Astrazeneca

LigandPNGBDBM35873(5,6-bis-(4-chloro-phenyl)-pyrazine-2-carboxylic ac...)
Affinity DataIC50: 4nMpH: 7.4 T: 2°CAssay Description:A GTP-gamma-S CB1 functional assay was used to assess the potency of the pyrazine derivatives. [35S]GTP-gamma-S binding assays were performed at 30 d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2009
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Astrazeneca

LigandPNGBDBM35871(N-(piperidin-1-yl)-5,6-dip-tolylpyrazine-2-carboxa...)
Affinity DataIC50: 6nMpH: 7.4 T: 2°CAssay Description:A GTP-gamma-S CB1 functional assay was used to assess the potency of the pyrazine derivatives. [35S]GTP-gamma-S binding assays were performed at 30 d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2009
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Astrazeneca

LigandPNGBDBM35877(N-cyclohexyl-5,6-bis(4-methoxyphenyl)pyrazine-2-ca...)
Affinity DataIC50: 8nMpH: 7.4 T: 2°CAssay Description:A GTP-gamma-S CB1 functional assay was used to assess the potency of the pyrazine derivatives. [35S]GTP-gamma-S binding assays were performed at 30 d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2009
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Astrazeneca

LigandPNGBDBM35868(CHEMBL226111 | 6-(4-chloro-phenyl)-5-(2,4-dichloro...)
Affinity DataIC50: 10nMpH: 7.4 T: 2°CAssay Description:A GTP-gamma-S CB1 functional assay was used to assess the potency of the pyrazine derivatives. [35S]GTP-gamma-S binding assays were performed at 30 d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2009
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Astrazeneca

LigandPNGBDBM35875(5,6-bis-(4-bromo-phenyl)-pyrazine-2-carboxylicacid...)
Affinity DataIC50: 11nMpH: 7.4 T: 2°CAssay Description:A GTP-gamma-S CB1 functional assay was used to assess the potency of the pyrazine derivatives. [35S]GTP-gamma-S binding assays were performed at 30 d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2009
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Astrazeneca

LigandPNGBDBM35876(CHEMBL375960 | 5,6-di-p-tolyl-pyrazine-2-carboxyli...)
Affinity DataIC50: 13nMpH: 7.4 T: 2°CAssay Description:A GTP-gamma-S CB1 functional assay was used to assess the potency of the pyrazine derivatives. [35S]GTP-gamma-S binding assays were performed at 30 d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2009
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Astrazeneca

LigandPNGBDBM35878(5,6-bis(4-chlorophenyl)-N-cyclohexylpyrazine-2-car...)
Affinity DataIC50: 19nMpH: 7.4 T: 2°CAssay Description:A GTP-gamma-S CB1 functional assay was used to assess the potency of the pyrazine derivatives. [35S]GTP-gamma-S binding assays were performed at 30 d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2009
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Astrazeneca

LigandPNGBDBM35872(CHEMBL226273 | 5,6-bis(4-methoxyphenyl)-N-(piperid...)
Affinity DataIC50: 21nMpH: 7.4 T: 2°CAssay Description:A GTP-gamma-S CB1 functional assay was used to assess the potency of the pyrazine derivatives. [35S]GTP-gamma-S binding assays were performed at 30 d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2009
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Astrazeneca

LigandPNGBDBM35883(CHEMBL376828 | 5,6-bis-(4-chloro-phenyl)-pyrazine-...)
Affinity DataIC50: 80nMpH: 7.4 T: 2°CAssay Description:A GTP-gamma-S CB1 functional assay was used to assess the potency of the pyrazine derivatives. [35S]GTP-gamma-S binding assays were performed at 30 d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2009
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Astrazeneca

LigandPNGBDBM35867(CHEMBL226110 | 5-(4-chloro-phenyl)-6-(2,4-dichloro...)
Affinity DataIC50: 114nMpH: 7.4 T: 2°CAssay Description:A GTP-gamma-S CB1 functional assay was used to assess the potency of the pyrazine derivatives. [35S]GTP-gamma-S binding assays were performed at 30 d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2009
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Astrazeneca

LigandPNGBDBM35882(5,6-bis(4-methoxyphenyl)-N-phenylpyrazine-2-carbox...)
Affinity DataIC50: 119nMpH: 7.4 T: 2°CAssay Description:A GTP-gamma-S CB1 functional assay was used to assess the potency of the pyrazine derivatives. [35S]GTP-gamma-S binding assays were performed at 30 d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2009
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Astrazeneca

LigandPNGBDBM35874(5,6-bis(2-chlorophenyl)-N-(piperidin-1-yl)pyrazine...)
Affinity DataIC50: 174nMpH: 7.4 T: 2°CAssay Description:A GTP-gamma-S CB1 functional assay was used to assess the potency of the pyrazine derivatives. [35S]GTP-gamma-S binding assays were performed at 30 d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2009
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Astrazeneca

LigandPNGBDBM35881(N-phenyl-5,6-dip-tolylpyrazine-2-carboxamide | 5,6...)
Affinity DataIC50: 326nMpH: 7.4 T: 2°CAssay Description:A GTP-gamma-S CB1 functional assay was used to assess the potency of the pyrazine derivatives. [35S]GTP-gamma-S binding assays were performed at 30 d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2009
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Astrazeneca

LigandPNGBDBM35884(5,6-bis-(2-chloro-phenyl)-pyrazine-2-carboxylicaci...)
Affinity DataIC50: 763nMpH: 7.4 T: 2°CAssay Description:A GTP-gamma-S CB1 functional assay was used to assess the potency of the pyrazine derivatives. [35S]GTP-gamma-S binding assays were performed at 30 d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2009
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Astrazeneca

LigandPNGBDBM35869(5,6-diphenyl-N-(piperidin-1-yl)pyrazine-2-carboxam...)
Affinity DataIC50: 766nMpH: 7.4 T: 2°CAssay Description:A GTP-gamma-S CB1 functional assay was used to assess the potency of the pyrazine derivatives. [35S]GTP-gamma-S binding assays were performed at 30 d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2009
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Astrazeneca

LigandPNGBDBM35879(5,6-bis-(2-chloro-phenyl)-pyrazine-2-carboxylicaci...)
Affinity DataIC50: 1.58E+3nMpH: 7.4 T: 2°CAssay Description:A GTP-gamma-S CB1 functional assay was used to assess the potency of the pyrazine derivatives. [35S]GTP-gamma-S binding assays were performed at 30 d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2009
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Astrazeneca

LigandPNGBDBM35880(N,5,6-triphenylpyrazine-2-carboxamide | 5,6-diphen...)
Affinity DataIC50: 2.79E+3nMpH: 7.4 T: 2°CAssay Description:A GTP-gamma-S CB1 functional assay was used to assess the potency of the pyrazine derivatives. [35S]GTP-gamma-S binding assays were performed at 30 d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2009
Entry Details Article
PubMed