Compile Data Set for Download or QSAR
Report error Found 32 Enz. Inhib. hit(s) with all data for entry = 2458
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

LigandPNGBDBM15359(17AAG | Tanespimycin | GLD-36 | (4E,6Z,8S,9S,10E,1...)
Affinity DataEC50:  7nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

LigandPNGBDBM20808(6-chloro-9-[(4-iodo-3,5-dimethylpyridin-2-yl)methy...)
Affinity DataEC50:  9nMAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

LigandPNGBDBM20807(9-[(4-bromo-3,5-dimethylpyridin-2-yl)methyl]-6-chl...)
Affinity DataEC50:  15nMAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

LigandPNGBDBM20799(CHEMBL468781 | 6-chloro-9-[(5-methoxy-4,6-dimethyl...)
Affinity DataEC50:  20nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

LigandPNGBDBM20813(6-chloro-9-{[3,5-dimethyl-4-(methylsulfanyl)pyridi...)
Affinity DataEC50:  27nMAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

LigandPNGBDBM20800(CHEMBL467399 | 6-chloro-9-[(4-methoxy-3,5-dimethyl...)
Affinity DataEC50:  30nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2008
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

LigandPNGBDBM20806(6-chloro-9-[(4-chloro-3,5-dimethylpyridin-2-yl)met...)
Affinity DataEC50:  38nMAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

LigandPNGBDBM20812(6-chloro-9-[(3,4,5-trimethylpyridin-2-yl)methyl]-9...)
Affinity DataEC50:  42nMAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

LigandPNGBDBM20789(6-chloro-9-[(2-chloro-3,4,5-trimethoxyphenyl)methy...)
Affinity DataEC50:  50nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

LigandPNGBDBM20792(6-bromo-9-[(2-bromo-3,4,5-trimethoxyphenyl)methyl]...)
Affinity DataEC50:  55nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

LigandPNGBDBM20790(9-[(2-bromo-3,4,5-trimethoxyphenyl)methyl]-6-chlor...)
Affinity DataEC50:  70nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

LigandPNGBDBM20804(2-[(2-amino-6-chloro-9H-purin-9-yl)methyl]-4-metho...)
Affinity DataEC50:  80nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

LigandPNGBDBM20805(6-chloro-9-[(6-chloro-4-methoxy-3,5-dimethylpyridi...)
Affinity DataEC50:  90nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

LigandPNGBDBM20753(9-{2-[(2,2-dimethylpropyl)amino]ethyl}-8-[(2-iodo-...)
Affinity DataEC50:  90nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

LigandPNGBDBM20791(6-chloro-9-[(2-iodo-3,4,5-trimethoxyphenyl)methyl]...)
Affinity DataEC50:  340nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

LigandPNGBDBM20795(2-amino-9-[(2-chloro-3,4,5-trimethoxyphenyl)methyl...)
Affinity DataEC50:  700nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

LigandPNGBDBM20811(2-[(2-amino-6-chloro-9H-purin-9-yl)methyl]-3,5-dim...)
Affinity DataEC50:  990nMAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

LigandPNGBDBM20809(6-chloro-9-[(3,5-dimethyl-4-nitropyridin-2-yl)meth...)
Affinity DataEC50:  1.00E+3nMAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

LigandPNGBDBM20802(6-chloro-9-[(4-ethoxy-3,5-dimethylpyridin-2-yl)met...)
Affinity DataEC50:  1.50E+3nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

LigandPNGBDBM20803(6-chloro-9-{[3,5-dimethyl-4-(propan-2-yloxy)pyridi...)
Affinity DataEC50:  1.50E+3nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

LigandPNGBDBM15381(8-[(2-chloro-3,4,5-trimethoxyphenyl)methyl]-2-fluo...)
Affinity DataEC50:  1.70E+3nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2008
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

LigandPNGBDBM20798(9-[(2-chloro-3,4,5-trimethoxyphenyl)methyl]-6-meth...)
Affinity DataEC50:  1.80E+3nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

LigandPNGBDBM20788(6-chloro-9-[(3,4,5-trimethoxyphenyl)methyl]-9H-pur...)
Affinity DataEC50:  2.00E+3nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

LigandPNGBDBM20787(6-chloro-9-[(2,5-dimethoxyphenyl)methyl]-9H-purin-...)
Affinity DataEC50:  3.00E+3nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

LigandPNGBDBM20810(9-[(4-amino-3,5-dimethylpyridin-2-yl)methyl]-6-chl...)
Affinity DataEC50:  5.80E+3nMAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

LigandPNGBDBM20815(6-chloro-9-[(3,5-dimethylpyridin-2-yl)methyl]-9H-p...)
Affinity DataEC50:  7.50E+3nMAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

LigandPNGBDBM20814(6-chloro-9-[(4-methanesulfinyl-3,5-dimethylpyridin...)
Affinity DataEC50: >1.00E+4nMAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

LigandPNGBDBM20793(9-[(2-bromo-3,4,5-trimethoxyphenyl)methyl]-9H-puri...)
Affinity DataEC50:  1.70E+4nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

LigandPNGBDBM20794(9-[(2-bromo-3,4,5-trimethoxyphenyl)methyl]-6-metho...)
Affinity DataEC50:  4.50E+4nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

LigandPNGBDBM20797(9-[(2-bromo-3,4,5-trimethoxyphenyl)methyl]-9H-puri...)
Affinity DataEC50:  5.00E+4nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

LigandPNGBDBM20801(2-[(2-amino-6-chloro-9H-purin-9-yl)methyl]-3,5-dim...)
Affinity DataEC50:  1.00E+5nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2008
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

LigandPNGBDBM20796(2-amino-9-[(2-bromo-3,4,5-trimethoxyphenyl)methyl]...)
Affinity DataEC50:  1.00E+5nMpH: 7.2 T: 2°CAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2008
Entry Details Article
PubMed