Compile Data Set for Download or QSAR
Report error Found 39 Enz. Inhib. hit(s) with all data for entry = 2111
Target3-phosphoinositide-dependent protein kinase 1(Human)
Berlex Biosciences

LigandPNGBDBM17048([(3Z)-2-oxo-3-[1-(1H-pyrrol-2-yl)propylidene]-2,3-...)
Affinity DataIC50: 3nMAssay Description:The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2007
Entry Details Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Berlex Biosciences

LigandPNGBDBM17004([(3Z)-2-oxo-3-[1-(1H-pyrrol-2-yl)ethylidene]-2,3-d...)
Affinity DataIC50: 5nMAssay Description:The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2007
Entry Details Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Berlex Biosciences

LigandPNGBDBM17004([(3Z)-2-oxo-3-[1-(1H-pyrrol-2-yl)ethylidene]-2,3-d...)
Affinity DataIC50: 6nMAssay Description:PDK1 inhibitory activity is measured directly using PDK1, a peptide substrate, 33PATP, and compound followed by capture on P81 phospho-cellulose pape...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2007
Entry Details Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Berlex Biosciences

LigandPNGBDBM17049([(3Z)-3-[(3-aminophenyl)(1H-pyrrol-2-yl)methyliden...)
Affinity DataIC50: 9nMAssay Description:The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2007
Entry Details Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Berlex Biosciences

LigandPNGBDBM17050([(3Z)-2-oxo-3-[pyridin-4-yl(1H-pyrrol-2-yl)methyli...)
Affinity DataIC50: 10nMAssay Description:The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2007
Entry Details Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Berlex Biosciences

LigandPNGBDBM17041((3Z)-2-oxo-3-[1-(1H-pyrrol-2-yl)propylidene]-2,3-d...)
Affinity DataIC50: 14nMAssay Description:The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2007
Entry Details Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Berlex Biosciences

LigandPNGBDBM16981(indolinone based inhibitor, 3l | [(3Z)-2-oxo-3-(1H...)
Affinity DataIC50: 18nMAssay Description:The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2007
Entry Details Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Berlex Biosciences

LigandPNGBDBM17042((3Z)-2-oxo-3-[phenyl(1H-pyrrol-2-yl)methylidene]-2...)
Affinity DataIC50: 29nMAssay Description:The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2007
Entry Details Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Berlex Biosciences

LigandPNGBDBM17043(ethyl 2-[(3E)-2-oxo-5-sulfamoyl-2,3-dihydro-1H-ind...)
Affinity DataIC50: 34nMAssay Description:The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2007
Entry Details Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Berlex Biosciences

LigandPNGBDBM17039(N-[(3Z)-2-oxo-3-(1H-pyrrol-2-ylmethylidene)-2,3-di...)
Affinity DataIC50: 55nMAssay Description:The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2007
Entry Details Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Berlex Biosciences

LigandPNGBDBM17040((3Z)-2-oxo-3-[1-(1H-pyrrol-2-yl)ethylidene]-2,3-di...)
Affinity DataIC50: 67nMAssay Description:The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2007
Entry Details Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Berlex Biosciences

LigandPNGBDBM17023((3Z)-5-hydroxy-3-[1-(1H-pyrrol-2-yl)ethylidene]-2,...)
Affinity DataIC50: 80nMpH: 7.2 T: 2°CAssay Description:The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2007
Entry Details Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Berlex Biosciences

LigandPNGBDBM17033((3Z)-2-oxo-3-(1H-pyrrol-2-ylmethylidene)-2,3-dihyd...)
Affinity DataIC50: 120nMpH: 7.2 T: 2°CAssay Description:The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2007
Entry Details Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Berlex Biosciences

LigandPNGBDBM17034((3Z)-3-(1H-pyrrol-2-ylmethylidene)-5-(1H-1,2,3,4-t...)
Affinity DataIC50: 200nMpH: 7.2 T: 2°CAssay Description:The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2007
Entry Details Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Berlex Biosciences

LigandPNGBDBM17032(CHEMBL107225 | (3Z)-2-oxo-3-(1H-pyrrol-2-ylmethyli...)
Affinity DataIC50: 260nMpH: 7.2 T: 2°CAssay Description:The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2007
Entry Details Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Berlex Biosciences

LigandPNGBDBM17024((3Z)-5-hydroxy-3-[(3-methyl-1H-pyrrol-2-yl)methyli...)
Affinity DataIC50: 280nMpH: 7.2 T: 2°CAssay Description:The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2007
Entry Details Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Berlex Biosciences

LigandPNGBDBM17025((3Z)-5-hydroxy-3-[(4-methyl-1H-pyrrol-2-yl)methyli...)
Affinity DataIC50: 280nMpH: 7.2 T: 2°CAssay Description:The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2007
Entry Details Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Berlex Biosciences

LigandPNGBDBM17030((3Z)-2-oxo-3-(1H-pyrrol-2-ylmethylidene)-2,3-dihyd...)
Affinity DataIC50: 290nMpH: 7.2 T: 2°CAssay Description:The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2007
Entry Details Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Berlex Biosciences

LigandPNGBDBM17020((3Z)-5-hydroxy-3-(1H-pyrrol-2-ylmethylidene)-2,3-d...)
Affinity DataIC50: 340nMpH: 7.2 T: 2°CAssay Description:The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2007
Entry Details Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Berlex Biosciences

LigandPNGBDBM17016(CHEMBL85403 | (3Z)-4-methyl-3-(1H-pyrrol-2-ylmethy...)
Affinity DataIC50: 510nMpH: 7.2 T: 2°CAssay Description:The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2007
Entry Details Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Berlex Biosciences

LigandPNGBDBM17038(N-[(3Z)-2-oxo-3-(1H-pyrrol-2-ylmethylidene)-2,3-di...)
Affinity DataIC50: 530nMAssay Description:The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2007
Entry Details Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Berlex Biosciences

LigandPNGBDBM17035((3Z)-5-amino-3-(1H-pyrrol-2-ylmethylidene)-2,3-dih...)
Affinity DataIC50: 580nMpH: 7.2 T: 2°CAssay Description:The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2007
Entry Details Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Berlex Biosciences

LigandPNGBDBM17029((3Z)-5-methoxy-3-(1H-pyrrol-2-ylmethylidene)-2,3-d...)
Affinity DataIC50: 580nMpH: 7.2 T: 2°CAssay Description:The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2007
Entry Details Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Berlex Biosciences

LigandPNGBDBM17031(methyl (3Z)-2-oxo-3-(1H-pyrrol-2-ylmethylidene)-2,...)
Affinity DataIC50: 670nMpH: 7.2 T: 2°CAssay Description:The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2007
Entry Details Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Berlex Biosciences

LigandPNGBDBM17026((3Z)-5-hydroxy-3-[(5-methyl-1H-pyrrol-2-yl)methyli...)
Affinity DataIC50: 680nMpH: 7.2 T: 2°CAssay Description:The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2007
Entry Details Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Berlex Biosciences

LigandPNGBDBM17021((3Z)-6-hydroxy-3-(1H-pyrrol-2-ylmethylidene)-2,3-d...)
Affinity DataIC50: 900nMpH: 7.2 T: 2°CAssay Description:The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2007
Entry Details Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Berlex Biosciences

LigandPNGBDBM17036((3Z)-2-oxo-3-(1H-pyrrol-2-ylmethylidene)-2,3-dihyd...)
Affinity DataIC50: 990nMpH: 7.2 T: 2°CAssay Description:The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2007
Entry Details Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Berlex Biosciences

LigandPNGBDBM17037((3Z)-5-(aminomethyl)-3-(1H-pyrrol-2-ylmethylidene)...)
Affinity DataIC50: 1.00E+3nMAssay Description:The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2007
Entry Details Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Berlex Biosciences

LigandPNGBDBM17019((3Z)-4-hydroxy-3-(1H-pyrrol-2-ylmethylidene)-2,3-d...)
Affinity DataIC50: 1.00E+3nMpH: 7.2 T: 2°CAssay Description:The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2007
Entry Details Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Berlex Biosciences

LigandPNGBDBM17028(CHEMBL426078 | (3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-y...)
Affinity DataIC50: 1.10E+3nMpH: 7.2 T: 2°CAssay Description:The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2007
Entry Details Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Berlex Biosciences

LigandPNGBDBM17015(CHEMBL86755 | Indolinone based inhibitor, 1 | (3Z)...)
Affinity DataIC50: 1.80E+3nMpH: 7.2 T: 2°CAssay Description:The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2007
Entry Details Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Berlex Biosciences

LigandPNGBDBM17027((3Z)-3-[(5-ethyl-1H-pyrrol-2-yl)methylidene]-5-hyd...)
Affinity DataIC50: 2.30E+3nMpH: 7.2 T: 2°CAssay Description:The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2007
Entry Details Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Berlex Biosciences

LigandPNGBDBM17017((3Z)-5-methyl-3-(1H-pyrrol-2-ylmethylidene)-2,3-di...)
Affinity DataIC50: 2.70E+3nMpH: 7.2 T: 2°CAssay Description:The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2007
Entry Details Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Berlex Biosciences

LigandPNGBDBM17045(2-[(3E)-2-oxo-5-sulfamoyl-2,3-dihydro-1H-indol-3-y...)
Affinity DataIC50: 3.90E+3nMAssay Description:The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2007
Entry Details Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Berlex Biosciences

LigandPNGBDBM17044(2-[(3E)-2-oxo-5-sulfamoyl-2,3-dihydro-1H-indol-3-y...)
Affinity DataIC50: 4.20E+3nMAssay Description:The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2007
Entry Details Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Berlex Biosciences

LigandPNGBDBM17047(N,N-diethyl-2-[(3E)-2-oxo-5-sulfamoyl-2,3-dihydro-...)
Affinity DataIC50: 5.40E+3nMAssay Description:The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2007
Entry Details Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Berlex Biosciences

LigandPNGBDBM17046(N-ethyl-2-[(3E)-2-oxo-5-sulfamoyl-2,3-dihydro-1H-i...)
Affinity DataIC50: 6.10E+3nMAssay Description:The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2007
Entry Details Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Berlex Biosciences

LigandPNGBDBM17022((3Z)-7-hydroxy-3-(1H-pyrrol-2-ylmethylidene)-2,3-d...)
Affinity DataIC50: 2.60E+4nMpH: 7.2 T: 2°CAssay Description:The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2007
Entry Details Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Berlex Biosciences

LigandPNGBDBM17018((3Z)-7-methyl-3-(1H-pyrrol-2-ylmethylidene)-2,3-di...)
Affinity DataIC50: 2.60E+4nMpH: 7.2 T: 2°CAssay Description:The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2007
Entry Details Article
PubMed