Compile Data Set for Download or QSAR
Report error Found 46 Enz. Inhib. hit(s) with all data for entry = 50020697
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216643(tert-butyl (R)-3-(3-fluorophenyl)-1-((R)-1-isoprop...)
Affinity DataIC50: 9nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216672(tert-butyl (R)-3-(2,6-difluorophenyl)-1-((R)-1-iso...)
Affinity DataIC50: 14nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216659(tert-butyl (R)-3-(2,5-difluorophenyl)-1-((R)-1-iso...)
Affinity DataIC50: 23nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216675(tert-butyl (R)-3-(2-fluoro-6-(trifluoromethyl)phen...)
Affinity DataIC50: 32nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216642(tert-butyl (R)-1-((S)-1-isopropyl-2-oxo-2,3,4,5-te...)
Affinity DataIC50: 32nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216671(tert-butyl (R)-1-((R)-1-isopropyl-2-oxo-2,3,4,5-te...)
Affinity DataIC50: 35nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216644(tert-butyl (R)-3-(2-fluorophenyl)-1-((R)-1-isoprop...)
Affinity DataIC50: 44nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216657(tert-butyl (R)-1-((R)-1-isopropyl-2-oxo-2,3,4,5-te...)
Affinity DataIC50: 45nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216661(tert-butyl (R)-3-(3-fluoro-2-(trifluoromethyl)phen...)
Affinity DataIC50: 65nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216668(tert-butyl (R)-3-(4-fluorophenyl)-1-((R)-1-methyl-...)
Affinity DataIC50: 71nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216640(tert-butyl (R)-1-((R)-1-(cyclopropylmethyl)-2-oxo-...)
Affinity DataIC50: 78nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216651(tert-butyl (R)-3-(2-fluorophenyl)-1-((R)-1-methyl-...)
Affinity DataIC50: 87nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216666(tert-butyl (R)-3-(4-fluorophenyl)-1-((R)-1-isoprop...)
Affinity DataIC50: 98nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216677(tert-butyl (R)-1-((R)-1-methyl-2-oxo-5-phenyl-2,3-...)
Affinity DataIC50: 125nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216645(tert-butyl (R)-1-((R)-1-isopropyl-2-oxo-2,3,4,5-te...)
Affinity DataIC50: 137nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216639(tert-butyl (R)-1-oxo-3-phenyl-1-((R)-1-(2,2,2-trif...)
Affinity DataIC50: 145nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216655(tert-butyl (R)-1-oxo-1-((R)-2-oxo-1-(2,2,2-trifluo...)
Affinity DataIC50: 150nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216670(benzyl (R)-1-((R)-1-methyl-2-oxo-5-phenyl-2,3-dihy...)
Affinity DataIC50: 150nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216664(tert-butyl (R)-1-((R)-1-methyl-2-oxo-2,3,4,5-tetra...)
Affinity DataIC50: 192nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216662(tert-butyl (S)-1-((R)-1-isopropyl-2-oxo-2,3,4,5-te...)
Affinity DataIC50: 214nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216673(tert-butyl (R)-1-((R)-1-methyl-2-oxo-5-phenyl-2,3-...)
Affinity DataIC50: 238nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216658(tert-butyl (R)-1-((R)-1-isopropyl-2-oxo-2,3,4,5-te...)
Affinity DataIC50: 295nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216646(tert-butyl (R)-2-((R)-1-methyl-2-oxo-5-phenyl-2,3-...)
Affinity DataIC50: 375nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216669(2,2-dimethyl-N-[(R)-1-((R)-1-methyl-2-oxo-5-phenyl...)
Affinity DataIC50: 380nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216656(adamantane-1-carboxylic acid [(R)-1-((R)-1-methyl-...)
Affinity DataIC50: 420nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216653(tert-butyl (R)-1-((R)-1-methyl-2-oxo-5-phenyl-2,3-...)
Affinity DataIC50: 684nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216654(tert-butyl (R)-1-((R)-2-oxo-1-(2,2,2-trifluoroethy...)
Affinity DataIC50: 885nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216667(tert-butyl (R)-1-((R)-1-methyl-2-oxo-5-phenyl-2,3-...)
Affinity DataIC50: 978nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216649(tert-butyl methyl((R)-1-((R)-1-methyl-2-oxo-5-phen...)
Affinity DataIC50: 1.00E+3nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216652(tert-butyl (R)-1-((R)-1-methyl-2-oxo-5-phenyl-2,3-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216648(tert-butyl (R)-1-((R)-1-methyl-2-oxoazepan-3-ylami...)
Affinity DataIC50: 1.00E+3nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216663((R)-N-((R)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216647(tert-butyl (R)-3-(1H-imidazol-4-yl)-1-((R)-1-methy...)
Affinity DataIC50: 1.00E+3nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216674((R)-N-((R)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216660(tert-butyl (R)-1-((R)-1-methyl-2,3,4,5-tetrahydro-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216637((R)-N-((R)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216650((R)-2-(3,3-dimethylbutylamino)-N-((R)-1-methyl-2-o...)
Affinity DataIC50: 1.00E+3nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216641(tert-butyl (R)-1-((R)-1-isopropyl-2-oxo-2,3,4,5-te...)
Affinity DataIC50: 1.00E+3nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50061212((R)-N-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benz...)
Affinity DataIC50: 1.00E+3nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216665(N-((R)-1-((R)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216638(tert-butyl (R)-3-cyclohexyl-1-((R)-1-methyl-2-oxo-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50019192((R)-2-amino-N-((R)-1-methyl-2-oxo-5-phenyl-2,3-dih...)
Affinity DataIC50: 1.00E+3nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216676(methyl (R)-1-((R)-1-methyl-2-oxo-5-phenyl-2,3-dihy...)
Affinity DataIC50: 1.00E+3nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216642(tert-butyl (R)-1-((S)-1-isopropyl-2-oxo-2,3,4,5-te...)
Affinity DataIC50: 1.73E+3nMAssay Description:Displacement of [3H]diltiazem from human Cav1.2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216671(tert-butyl (R)-1-((R)-1-isopropyl-2-oxo-2,3,4,5-te...)
Affinity DataIC50: 3.50E+3nMAssay Description:Displacement of [3H]diltiazem from human Cav1.2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216671(tert-butyl (R)-1-((R)-1-isopropyl-2-oxo-2,3,4,5-te...)
Affinity DataKi:  40nMAssay Description:Binding affinity at human inactive state Nav1.7 by whole cell electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed