Compile Data Set for Download or QSAR
Report error Found 57 Enz. Inhib. hit(s) with all data for entry = 50021019
TargetCytochrome P450 3A4(Human)
Astrazeneca Discovery

Curated by ChEMBL
LigandPNGBDBM50220023((5R)-3-{3-fluoro-4-[6-(1H-imidazol-1-ylacetyl)pyri...)
Affinity DataIC50: 300nMAssay Description:Inhibition of human recombinant CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Astrazeneca Discovery

Curated by ChEMBL
LigandPNGBDBM50220012((5R)-3-(3-fluoro-4-pyridin-3-ylphenyl)-5-(1H-1,2,3...)
Affinity DataIC50: 6.60E+3nMAssay Description:Inhibition of human recombinant CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Astrazeneca Discovery

Curated by ChEMBL
LigandPNGBDBM50220012((5R)-3-(3-fluoro-4-pyridin-3-ylphenyl)-5-(1H-1,2,3...)
Affinity DataIC50: 6.80E+3nMAssay Description:Inhibition of human recombinant CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Astrazeneca Discovery

Curated by ChEMBL
LigandPNGBDBM50220023((5R)-3-{3-fluoro-4-[6-(1H-imidazol-1-ylacetyl)pyri...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of human recombinant CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Astrazeneca Discovery

Curated by ChEMBL
LigandPNGBDBM50220019((5R)-3-(4-{6-[(2,5-dimethyl-1H-imidazol-1-yl)acety...)
Affinity DataIC50: 1.07E+4nMAssay Description:Inhibition of human recombinant CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Astrazeneca Discovery

Curated by ChEMBL
LigandPNGBDBM50220026((5R)-3-(3-fluoro-4-{6-[(2-methyl-1H-imidazol-1-yl)...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Astrazeneca Discovery

Curated by ChEMBL
LigandPNGBDBM50220012((5R)-3-(3-fluoro-4-pyridin-3-ylphenyl)-5-(1H-1,2,3...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Astrazeneca Discovery

Curated by ChEMBL
LigandPNGBDBM50220015((5R)-3-{3-fluoro-4-[6-(hydroxymethyl)pyridin-3-yl]...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Astrazeneca Discovery

Curated by ChEMBL
LigandPNGBDBM50220019((5R)-3-(4-{6-[(2,5-dimethyl-1H-imidazol-1-yl)acety...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Astrazeneca Discovery

Curated by ChEMBL
LigandPNGBDBM50220026((5R)-3-(3-fluoro-4-{6-[(2-methyl-1H-imidazol-1-yl)...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Astrazeneca Discovery

Curated by ChEMBL
LigandPNGBDBM50220015((5R)-3-{3-fluoro-4-[6-(hydroxymethyl)pyridin-3-yl]...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Astrazeneca Discovery

Curated by ChEMBL
LigandPNGBDBM50220023((5R)-3-{3-fluoro-4-[6-(1H-imidazol-1-ylacetyl)pyri...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Astrazeneca Discovery

Curated by ChEMBL
LigandPNGBDBM50220019((5R)-3-(4-{6-[(2,5-dimethyl-1H-imidazol-1-yl)acety...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Astrazeneca Discovery

Curated by ChEMBL
LigandPNGBDBM50220019((5R)-3-(4-{6-[(2,5-dimethyl-1H-imidazol-1-yl)acety...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Astrazeneca Discovery

Curated by ChEMBL
LigandPNGBDBM50220015((5R)-3-{3-fluoro-4-[6-(hydroxymethyl)pyridin-3-yl]...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Astrazeneca Discovery

Curated by ChEMBL
LigandPNGBDBM50220023((5R)-3-{3-fluoro-4-[6-(1H-imidazol-1-ylacetyl)pyri...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Astrazeneca Discovery

Curated by ChEMBL
LigandPNGBDBM50220026((5R)-3-(3-fluoro-4-{6-[(2-methyl-1H-imidazol-1-yl)...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Astrazeneca Discovery

Curated by ChEMBL
LigandPNGBDBM50220017((5R)-3-(3-fluoro-4-{6-[(4-methyl-1H-imidazol-1-yl)...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Astrazeneca Discovery

Curated by ChEMBL
LigandPNGBDBM50220017((5R)-3-(3-fluoro-4-{6-[(4-methyl-1H-imidazol-1-yl)...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Astrazeneca Discovery

Curated by ChEMBL
LigandPNGBDBM50220017((5R)-3-(3-fluoro-4-{6-[(4-methyl-1H-imidazol-1-yl)...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Astrazeneca Discovery

Curated by ChEMBL
LigandPNGBDBM50220015((5R)-3-{3-fluoro-4-[6-(hydroxymethyl)pyridin-3-yl]...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Astrazeneca Discovery

Curated by ChEMBL
LigandPNGBDBM50220017((5R)-3-(3-fluoro-4-{6-[(4-methyl-1H-imidazol-1-yl)...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Astrazeneca Discovery

Curated by ChEMBL
LigandPNGBDBM50220026((5R)-3-(3-fluoro-4-{6-[(2-methyl-1H-imidazol-1-yl)...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Astrazeneca Discovery

Curated by ChEMBL
LigandPNGBDBM50220026((5R)-3-(3-fluoro-4-{6-[(2-methyl-1H-imidazol-1-yl)...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Astrazeneca Discovery

Curated by ChEMBL
LigandPNGBDBM50220019((5R)-3-(4-{6-[(2,5-dimethyl-1H-imidazol-1-yl)acety...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Astrazeneca Discovery

Curated by ChEMBL
LigandPNGBDBM50220017((5R)-3-(3-fluoro-4-{6-[(4-methyl-1H-imidazol-1-yl)...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Astrazeneca Discovery

Curated by ChEMBL
LigandPNGBDBM50220012((5R)-3-(3-fluoro-4-pyridin-3-ylphenyl)-5-(1H-1,2,3...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Astrazeneca Discovery

Curated by ChEMBL
LigandPNGBDBM50220023((5R)-3-{3-fluoro-4-[6-(1H-imidazol-1-ylacetyl)pyri...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Astrazeneca Discovery

Curated by ChEMBL
LigandPNGBDBM50220012((5R)-3-(3-fluoro-4-pyridin-3-ylphenyl)-5-(1H-1,2,3...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Astrazeneca Discovery

Curated by ChEMBL
LigandPNGBDBM50220015((5R)-3-{3-fluoro-4-[6-(hydroxymethyl)pyridin-3-yl]...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Astrazeneca Discovery

Curated by ChEMBL
LigandPNGBDBM50220018((5R)-3-[4-(6-acetylpyridin-3-yl)-3-fluorophenyl]-5...)
Affinity DataKi:  700nMAssay Description:Inhibition of human liver MAOA expressed in yeastMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Astrazeneca Discovery

Curated by ChEMBL
LigandPNGBDBM50220036((5R)-3-{3-fluoro-4-[6-(methoxymethyl)pyridin-3-yl]...)
Affinity DataKi:  1.70E+3nMAssay Description:Inhibition of human liver MAOA expressed in yeastMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Astrazeneca Discovery

Curated by ChEMBL
LigandPNGBDBM50220028((5R)-3-(3-fluoro-4-{6-[(1S)-1-methoxyethyl]pyridin...)
Affinity DataKi:  2.50E+3nMAssay Description:Inhibition of human liver MAOA expressed in yeastMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Astrazeneca Discovery

Curated by ChEMBL
LigandPNGBDBM50220033((5R)-3-(3-fluoro-4-{6-[(1R)-1-methoxyethyl]pyridin...)
Affinity DataKi:  3.00E+3nMAssay Description:Inhibition of human liver MAOA expressed in yeastMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Astrazeneca Discovery

Curated by ChEMBL
LigandPNGBDBM50220029((5R)-3-(3-fluoro-4-{6-[(1R)-1-hydroxyethyl]pyridin...)
Affinity DataKi:  4.30E+3nMAssay Description:Inhibition of human liver MAOA expressed in yeastMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Astrazeneca Discovery

Curated by ChEMBL
LigandPNGBDBM50220034((5R)-3-{4-[6-(azetidin-3-ylcarbonyl)pyridin-3-yl]-...)
Affinity DataKi:  4.50E+3nMAssay Description:Inhibition of human liver MAOA expressed in yeastMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Astrazeneca Discovery

Curated by ChEMBL
LigandPNGBDBM50220015((5R)-3-{3-fluoro-4-[6-(hydroxymethyl)pyridin-3-yl]...)
Affinity DataKi:  4.80E+3nMAssay Description:Inhibition of human liver MAOA expressed in yeastMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Astrazeneca Discovery

Curated by ChEMBL
LigandPNGBDBM50220017((5R)-3-(3-fluoro-4-{6-[(4-methyl-1H-imidazol-1-yl)...)
Affinity DataKi: >5.60E+3nMAssay Description:Inhibition of human liver MAOA expressed in yeastMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Astrazeneca Discovery

Curated by ChEMBL
LigandPNGBDBM50220032((5R)-3-(3-fluoro-4-{6-[(1S)-1-hydroxyethyl]pyridin...)
Affinity DataKi:  5.90E+3nMAssay Description:Inhibition of human liver MAOA expressed in yeastMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Astrazeneca Discovery

Curated by ChEMBL
LigandPNGBDBM50220021((5R)-3-{3-fluoro-4-[6-(1-hydroxy-1-methylethyl)pyr...)
Affinity DataKi:  6.00E+3nMAssay Description:Inhibition of human liver MAOA expressed in yeastMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Astrazeneca Discovery

Curated by ChEMBL
LigandPNGBDBM50220035((5R)-3-(3-fluoro-4-{6-[4-(4-methylpiperazin-1-yl)b...)
Affinity DataKi:  1.05E+4nMAssay Description:Inhibition of human liver MAOA expressed in yeastMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Astrazeneca Discovery

Curated by ChEMBL
LigandPNGBDBM50220027((5R)-3-(4-{6-[(2,4-dimethyl-1H-imidazol-1-yl)acety...)
Affinity DataKi: >1.10E+4nMAssay Description:Inhibition of human liver MAOA expressed in yeastMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Astrazeneca Discovery

Curated by ChEMBL
LigandPNGBDBM50220022((5R)-3-{3-fluoro-4-[6-(1-hydroxy-2-methylpropyl)py...)
Affinity DataKi:  1.13E+4nMAssay Description:Inhibition of human liver MAOA expressed in yeastMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Astrazeneca Discovery

Curated by ChEMBL
LigandPNGBDBM50220023((5R)-3-{3-fluoro-4-[6-(1H-imidazol-1-ylacetyl)pyri...)
Affinity DataKi: >1.20E+4nMAssay Description:Inhibition of human liver MAOA expressed in yeastMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Astrazeneca Discovery

Curated by ChEMBL
LigandPNGBDBM50220038((5R)-3-{3-fluoro-4-[6-(4-morpholin-4-ylbutanoyl)py...)
Affinity DataKi:  1.50E+4nMAssay Description:Inhibition of human liver MAOA expressed in yeastMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Astrazeneca Discovery

Curated by ChEMBL
LigandPNGBDBM50220019((5R)-3-(4-{6-[(2,5-dimethyl-1H-imidazol-1-yl)acety...)
Affinity DataKi:  1.90E+4nMAssay Description:Inhibition of human liver MAOA expressed in yeastMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Astrazeneca Discovery

Curated by ChEMBL
LigandPNGBDBM50220013((5R)-3-{3-fluoro-4-[6-(piperidin-4-ylacetyl)pyridi...)
Affinity DataKi:  2.80E+4nMAssay Description:Inhibition of human liver MAOA expressed in yeastMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Astrazeneca Discovery

Curated by ChEMBL
LigandPNGBDBM50220039((5R)-3-(3-fluoro-4-{6-[1-hydroxy-4-(4-methylpipera...)
Affinity DataKi:  4.10E+4nMAssay Description:Inhibition of human liver MAOA expressed in yeastMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Astrazeneca Discovery

Curated by ChEMBL
LigandPNGBDBM50220024((5R)-3-{3-fluoro-4-[6-(piperidin-4-ylcarbonyl)pyri...)
Affinity DataKi: >4.40E+4nMAssay Description:Inhibition of human liver MAOA expressed in yeastMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Astrazeneca Discovery

Curated by ChEMBL
LigandPNGBDBM50220016((5R)-3-(4-{6-[(2-ethyl-1H-imidazol-1-yl)acetyl]pyr...)
Affinity DataKi: >4.40E+4nMAssay Description:Inhibition of human liver MAOA expressed in yeastMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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