Compile Data Set for Download or QSAR
Report error Found 12 Enz. Inhib. hit(s) with all data for entry = 2245
TargetALK tyrosine kinase receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Affinity DataIC50: 2nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18161(DHT | Dihydrotestosterone | [3H]DHT | (5alpha,17be...)
Affinity DataKi:  0.200nM ΔG°:  -57.6kJ/mole EC50:  5.10nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18522(6-[(2R,5R)-2-methyl-5-[(1R)-2,2,2-trifluoro-1-hydr...)
Affinity DataKi:  1.5nM ΔG°:  -52.4kJ/mole EC50:  7.10nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18524(6-[bis(2,2,2-trifluoroethyl)amino]-4-(trifluoromet...)
Affinity DataKi:  4.60nM ΔG°:  -49.5kJ/mole EC50:  0.200nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18523(6-[(2R,5R)-2-methyl-5-[(1S)-2,2,2-trifluoro-1-hydr...)
Affinity DataKi:  7.60nM ΔG°:  -48.2kJ/mole EC50:  8.40nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18521(6-[(2R,5R)-2-(chloromethyl)-5-methylpyrrolidin-1-y...)
Affinity DataKi:  10nM ΔG°:  -47.5kJ/mole EC50:  12nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18518(6-[(2R,5S)-2,5-dimethylpyrrolidin-1-yl]-4-(trifluo...)
Affinity DataKi:  19nM ΔG°:  -45.8kJ/mole EC50:  2.60nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18519(6-[(2R,5R)-2,5-dimethylpyrrolidin-1-yl]-4-(trifluo...)
Affinity DataKi:  43nM ΔG°:  -43.7kJ/mole EC50:  48nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18520(6-[(2R,5R)-2-(hydroxymethyl)-5-methylpyrrolidin-1-...)
Affinity DataKi:  70nM ΔG°:  -42.5kJ/mole EC50:  21nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18525(N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluoro...)
Affinity DataKi:  70nM ΔG°:  -42.5kJ/mole IC50: 128nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18517(6-(2-methylpyrrolidin-1-yl)-4-(trifluoromethyl)-1,...)
Affinity DataKi:  72nM ΔG°:  -42.4kJ/mole EC50:  13nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18516(6-(pyrrolidin-1-yl)-4-(trifluoromethyl)-1,2-dihydr...)
Affinity DataKi:  1.70E+3nM ΔG°:  -34.3kJ/mole IC50: 25nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMed