Compile Data Set for Download or QSAR
Report error Found 34 Enz. Inhib. hit(s) with all data for entry = 50037984
TargetSerine/threonine-protein kinase Chk1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50222917(4'-[5-(6-piperidin-1-ylmethyl-pyridin-3-ylamino)-1...)
Affinity DataEC50:  150nMAssay Description:Activity at human CHK1 in CA46 cells by histone H3 ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50222916(4'-{5-[4-(dimethylamino-methyl)-phenylamino]-2H-py...)
Affinity DataEC50:  58nMAssay Description:Activity at human CHK1 in CA46 cells by histone H3 ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50222914(4'-[5-(4-cyclopropylaminomethyl-phenylamino)-2H-py...)
Affinity DataEC50:  60nMAssay Description:Activity at human CHK1 in CA46 cells by histone H3 ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50222919(4'-(5-{6-[(cyclopropylmethyl-amino)-methyl]-pyridi...)
Affinity DataEC50:  165nMAssay Description:Activity at human CHK1 in CA46 cells by histone H3 ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50222921(3-(1H-benzo[d]imidazol-2-yl)-N-(2,4-dihydroxypheny...)
Affinity DataEC50:  550nMAssay Description:Activity at human CHK1 in CA46 cells by histone H3 ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50222920(4'-{5-[6-(sec-butylamino-methyl)-pyridin-3-ylamino...)
Affinity DataEC50:  230nMAssay Description:Activity at human CHK1 in CA46 cells by histone H3 ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50222913(4'-{5-[4-(isopropylamino-methyl)-phenylamino]-2H-p...)
Affinity DataEC50:  70nMAssay Description:Activity at human CHK1 in CA46 cells by histone H3 ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50222915(4'-[5-(4-pyrrolidin-1-ylmethyl-phenylamino)-1H-pyr...)
Affinity DataEC50:  41nMAssay Description:Activity at human CHK1 in CA46 cells by histone H3 ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50222918(4'-(5-phenylamino-2H-pyrazol-3-yl)-biphenyl-2,4-di...)
Affinity DataEC50:  500nMAssay Description:Activity at human CHK1 in CA46 cells by histone H3 ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Sgk1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50222913(4'-{5-[4-(isopropylamino-methyl)-phenylamino]-2H-p...)
Affinity DataIC50: 290nMAssay Description:Inhibition of human SGKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Nek2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50222913(4'-{5-[4-(isopropylamino-methyl)-phenylamino]-2H-p...)
Affinity DataIC50: 1.04E+3nMAssay Description:Inhibition of NEK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50222913(4'-{5-[4-(isopropylamino-methyl)-phenylamino]-2H-p...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of ABLMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50222913(4'-{5-[4-(isopropylamino-methyl)-phenylamino]-2H-p...)
Affinity DataIC50: 1.72E+3nMAssay Description:Inhibition of PIM2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase 26(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50222913(4'-{5-[4-(isopropylamino-methyl)-phenylamino]-2H-p...)
Affinity DataIC50: 1.85E+3nMAssay Description:Inhibition of MASKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
LigandPNGBDBM50222913(4'-{5-[4-(isopropylamino-methyl)-phenylamino]-2H-p...)
Affinity DataIC50: 2.13E+3nMAssay Description:Inhibition of CAMK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50222913(4'-{5-[4-(isopropylamino-methyl)-phenylamino]-2H-p...)
Affinity DataIC50: 2.55E+3nMAssay Description:Inhibition of human LCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50222913(4'-{5-[4-(isopropylamino-methyl)-phenylamino]-2H-p...)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of CDK1 expressed in Sf21 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetCasein kinase I isoform delta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50222913(4'-{5-[4-(isopropylamino-methyl)-phenylamino]-2H-p...)
Affinity DataIC50: 6.34E+3nMAssay Description:Inhibition of CK1deltaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50222913(4'-{5-[4-(isopropylamino-methyl)-phenylamino]-2H-p...)
Affinity DataIC50: 1.01E+4nMAssay Description:Inhibition of Aurora AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50222913(4'-{5-[4-(isopropylamino-methyl)-phenylamino]-2H-p...)
Affinity DataIC50: 1.44E+4nMAssay Description:Inhibition of PAK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
LigandPNGBDBM50222913(4'-{5-[4-(isopropylamino-methyl)-phenylamino]-2H-p...)
Affinity DataIC50: 2.69E+4nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50222913(4'-{5-[4-(isopropylamino-methyl)-phenylamino]-2H-p...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of INSRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50222913(4'-{5-[4-(isopropylamino-methyl)-phenylamino]-2H-p...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase beta-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50222913(4'-{5-[4-(isopropylamino-methyl)-phenylamino]-2H-p...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of p70S6KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50222915(4'-[5-(4-pyrrolidin-1-ylmethyl-phenylamino)-1H-pyr...)
Affinity DataKi:  0.180nMAssay Description:Inhibition of human CHK1 expressed in baculovirus/insect cell systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50222916(4'-{5-[4-(dimethylamino-methyl)-phenylamino]-2H-py...)
Affinity DataKi:  0.190nMAssay Description:Inhibition of human CHK1 expressed in baculovirus/insect cell systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50222920(4'-{5-[6-(sec-butylamino-methyl)-pyridin-3-ylamino...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of human CHK1 expressed in baculovirus/insect cell systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50222917(4'-[5-(6-piperidin-1-ylmethyl-pyridin-3-ylamino)-1...)
Affinity DataKi:  0.300nMAssay Description:Inhibition of human CHK1 expressed in baculovirus/insect cell systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50222913(4'-{5-[4-(isopropylamino-methyl)-phenylamino]-2H-p...)
Affinity DataKi:  0.360nMAssay Description:Inhibition of human CHK1 expressed in baculovirus/insect cell systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50222914(4'-[5-(4-cyclopropylaminomethyl-phenylamino)-2H-py...)
Affinity DataKi:  0.380nMAssay Description:Inhibition of human CHK1 expressed in baculovirus/insect cell systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50222921(3-(1H-benzo[d]imidazol-2-yl)-N-(2,4-dihydroxypheny...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of human CHK1 expressed in baculovirus/insect cell systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50222919(4'-(5-{6-[(cyclopropylmethyl-amino)-methyl]-pyridi...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of human CHK1 expressed in baculovirus/insect cell systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50222918(4'-(5-phenylamino-2H-pyrazol-3-yl)-biphenyl-2,4-di...)
Affinity DataKi:  1.20nMAssay Description:Inhibition of human CHK1 expressed in baculovirus/insect cell systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50222922(3-(1H-benzo[d]imidazol-2-yl)-N-(4-hydroxyphenyl)-1...)
Affinity DataKi:  301nMAssay Description:Inhibition of human CHK1 expressed in baculovirus/insect cell systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed