Compile Data Set for Download or QSAR
Report error Found 24 Enz. Inhib. hit(s) with all data for entry = 50021442
TargetUrotensin-2 receptor(Rat)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50224715(tert-butyl 4-(2-(5-chloro-2-(1-(2-(3-oxo-2,3-dihyd...)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at rat UT receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetUrotensin-2 receptor(Rat)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50224718(N-((1-(benzylsulfonyl)piperidin-4-yl)methyl)-5-chl...)
Affinity DataIC50: 53nMAssay Description:Antagonist activity at rat UT receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetUrotensin-2 receptor(Rat)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50224721(tert-butyl 4-(2-(5-chloro-2-(1-(2-(3-oxo-2,3-dihyd...)
Affinity DataIC50: 100nMAssay Description:Antagonist activity at rat UT receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetUrotensin-2 receptor(Rat)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50224727(N-benzyl-4-((5-chloro-2-(1-(2-(3-oxo-2,3-dihydrobe...)
Affinity DataIC50: 210nMAssay Description:Antagonist activity at rat UT receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetUrotensin-2 receptor(Rat)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50224717(5-chloro-N-((1-(3,3-dimethylbutanoyl)piperidin-4-y...)
Affinity DataIC50: 330nMAssay Description:Antagonist activity at rat UT receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetUrotensin-2 receptor(Rat)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50224719(benzyl 4-((5-chloro-2-(1-(2-(3-oxo-2,3-dihydrobenz...)
Affinity DataIC50: 400nMAssay Description:Antagonist activity at rat UT receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetUrotensin-2 receptor(Rat)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50224716(N-((1-benzoylpiperidin-4-yl)methyl)-5-chloro-2-(1-...)
Affinity DataIC50: 520nMAssay Description:Antagonist activity at rat UT receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetUrotensin-2 receptor(Rat)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50224724(tert-butyl 4-((5-chloro-2-(1-(2-(3-oxo-2,3-dihydro...)
Affinity DataIC50: 600nMAssay Description:Antagonist activity at rat UT receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetUrotensin-2 receptor(Rat)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50224728(5-chloro-2-(1-(2-(3-oxo-2,3-dihydrobenzo[b][1,4]ox...)
Affinity DataIC50: 1.90E+3nMAssay Description:Antagonist activity at rat UT receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetUrotensin-2 receptor(Rat)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50224722(tert-butyl 4-((2-(1-(2-(3-oxo-2,3-dihydrobenzo[b][...)
Affinity DataIC50: 2.50E+3nMAssay Description:Antagonist activity at rat UT receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetUrotensin-2 receptor(Rat)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50224729(4-(4-chlorophenyl)-N,N-dimethyl-1-(2-(3-oxo-2,3-di...)
Affinity DataIC50: 7.10E+3nMAssay Description:Antagonist activity at rat UT receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetUrotensin-2 receptor(Rat)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50224725(N-methyl-1-(2-(3-oxo-2,3-dihydrobenzo[b][1,4]oxazi...)
Affinity DataIC50: 9.10E+3nMAssay Description:Antagonist activity at rat UT receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetUrotensin-2 receptor(Rat)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50224720(N-methyl-1-(2-(3-oxo-2,3-dihydrobenzo[b][1,4]oxazi...)
Affinity DataIC50: 1.20E+4nMAssay Description:Antagonist activity at rat UT receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetUrotensin-2 receptor(Rat)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50224723(N,N-dimethyl-1-(2-(3-oxo-2,3-dihydrobenzo[b][1,4]o...)
Affinity DataIC50: 2.40E+4nMAssay Description:Antagonist activity at rat UT receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetUrotensin-2 receptor(Rat)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50224726(N-benzyl-1-(2-(3-oxo-2,3-dihydrobenzo[b][1,4]oxazi...)
Affinity DataIC50: 4.30E+4nMAssay Description:Antagonist activity at rat UT receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetUrotensin-2 receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50224717(5-chloro-N-((1-(3,3-dimethylbutanoyl)piperidin-4-y...)
Affinity DataKi:  27nMAssay Description:Displacement of [125I]U2 from human UT receptor in RMS13 cells after 2.5 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetUrotensin-2 receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50224718(N-((1-(benzylsulfonyl)piperidin-4-yl)methyl)-5-chl...)
Affinity DataKi:  30nMAssay Description:Displacement of [125I]U2 from human UT receptor in RMS13 cells after 2.5 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetUrotensin-2 receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50224727(N-benzyl-4-((5-chloro-2-(1-(2-(3-oxo-2,3-dihydrobe...)
Affinity DataKi:  30nMAssay Description:Displacement of [125I]U2 from human UT receptor in RMS13 cells after 2.5 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetUrotensin-2 receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50224719(benzyl 4-((5-chloro-2-(1-(2-(3-oxo-2,3-dihydrobenz...)
Affinity DataKi:  54nMAssay Description:Displacement of [125I]U2 from human UT receptor in RMS13 cells after 2.5 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetUrotensin-2 receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50224715(tert-butyl 4-(2-(5-chloro-2-(1-(2-(3-oxo-2,3-dihyd...)
Affinity DataKi:  65nMAssay Description:Displacement of [125I]U2 from human UT receptor in RMS13 cells after 2.5 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetUrotensin-2 receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50224721(tert-butyl 4-(2-(5-chloro-2-(1-(2-(3-oxo-2,3-dihyd...)
Affinity DataKi:  77nMAssay Description:Displacement of [125I]U2 from human UT receptor in RMS13 cells after 2.5 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetUrotensin-2 receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50224724(tert-butyl 4-((5-chloro-2-(1-(2-(3-oxo-2,3-dihydro...)
Affinity DataKi:  140nMAssay Description:Displacement of [125I]U2 from human UT receptor in RMS13 cells after 2.5 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetUrotensin-2 receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50224716(N-((1-benzoylpiperidin-4-yl)methyl)-5-chloro-2-(1-...)
Affinity DataKi:  160nMAssay Description:Displacement of [125I]U2 from human UT receptor in RMS13 cells after 2.5 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetUrotensin-2 receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50224722(tert-butyl 4-((2-(1-(2-(3-oxo-2,3-dihydrobenzo[b][...)
Affinity DataKi:  430nMAssay Description:Displacement of [125I]U2 from human UT receptor in RMS13 cells after 2.5 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed