Compile Data Set for Download or QSAR
Report error Found 26 Enz. Inhib. hit(s) with all data for entry = 2401
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM20079(5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...)
Affinity DataKi:  1.30nM ΔG°:  -52.8kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM20061(6-chloro-5-(cyclopent-1-en-1-yl)-1,2,3,4-tetrahydr...)
Affinity DataKi:  200nM ΔG°:  -39.8kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM20069(6-chloro-5-(thiophen-2-yl)-1,2,3,4-tetrahydropyrim...)
Affinity DataKi:  280nM ΔG°:  -38.9kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM20065(6-chloro-5-phenyl-1,2,3,4-tetrahydropyrimidine-2,4...)
Affinity DataKi:  400nM ΔG°:  -38.0kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM20073(6-chloro-5-[(1E)-pent-1-en-1-yl]-1,2,3,4-tetrahydr...)
Affinity DataKi:  410nM ΔG°:  -37.9kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM20062(6-chloro-5-(cyclohex-1-en-1-yl)-1,2,3,4-tetrahydro...)
Affinity DataKi:  420nM ΔG°:  -37.9kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM20064(6-chloro-5-[(2E)-pent-2-en-3-yl]-1,2,3,4-tetrahydr...)
Affinity DataKi:  490nM ΔG°:  -37.5kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM20075(6-fluoro-5-phenyl-1,2,3,4-tetrahydropyrimidine-2,4...)
Affinity DataKi:  500nM ΔG°:  -37.4kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM20072(5-[(1E)-but-1-en-1-yl]-6-chloro-1,2,3,4-tetrahydro...)
Affinity DataKi:  630nM ΔG°:  -36.8kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM20068(6-chloro-5-(4-fluorophenyl)-1,2,3,4-tetrahydropyri...)
Affinity DataKi:  710nM ΔG°:  -36.5kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM20056(5-butyl-6-chloro-1,2,3,4-tetrahydropyrimidine-2,4-...)
Affinity DataKi:  1.03E+3nM ΔG°:  -35.5kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM20059(6-chloro-5-heptyl-1,2,3,4-tetrahydropyrimidine-2,4...)
Affinity DataKi:  1.06E+3nM ΔG°:  -35.5kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM20071(6-chloro-5-[(1E)-prop-1-en-1-yl]-1,2,3,4-tetrahydr...)
Affinity DataKi:  1.17E+3nM ΔG°:  -35.2kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM20076(6-bromo-5-phenyl-1,2,3,4-tetrahydropyrimidine-2,4-...)
Affinity DataKi:  1.21E+3nM ΔG°:  -35.1kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM20066(6-chloro-5-(3,5-dimethylphenyl)-1,2,3,4-tetrahydro...)
Affinity DataKi:  1.74E+3nM ΔG°:  -34.2kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM20058(6-chloro-5-hexyl-1,2,3,4-tetrahydropyrimidine-2,4-...)
Affinity DataKi:  1.83E+3nM ΔG°:  -34.1kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM20070(6-chloro-5-(pyridin-3-yl)-1,2,3,4-tetrahydropyrimi...)
Affinity DataKi:  3.01E+3nM ΔG°:  -32.8kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM20063(6-chloro-5-(prop-1-en-2-yl)-1,2,3,4-tetrahydropyri...)
Affinity DataKi:  3.34E+3nM ΔG°:  -32.5kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM20057(6-chloro-5-pentyl-1,2,3,4-tetrahydropyrimidine-2,4...)
Affinity DataKi:  3.67E+3nM ΔG°:  -32.3kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM20067(6-chloro-5-(naphthalen-1-yl)-1,2,3,4-tetrahydropyr...)
Affinity DataKi:  4.59E+3nM ΔG°:  -31.7kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM20060(5-benzyl-6-chloro-1,2,3,4-tetrahydropyrimidine-2,4...)
Affinity DataKi:  4.65E+3nM ΔG°:  -31.7kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM20055(6-chloro-5-propyl-1,2,3,4-tetrahydropyrimidine-2,4...)
Affinity DataKi:  5.81E+3nM ΔG°:  -31.1kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM20077(5-phenyl-6-(pyrrolidin-1-yl)-1,2,3,4-tetrahydropyr...)
Affinity DataKi: >2.00E+4nM ΔG°: >-27.9kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM20078(6-[(2-aminoethyl)amino]-5-phenyl-1,2,3,4-tetrahydr...)
Affinity DataKi: >2.00E+4nM ΔG°: >-27.9kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM20054(6-chloro-5-ethyl-1,2,3,4-tetrahydropyrimidine-2,4-...)
Affinity DataKi: >2.00E+4nM ΔG°: >-27.9kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM20074(6-methyl-5-phenyl-1,2,3,4-tetrahydropyrimidine-2,4...)
Affinity DataKi: >2.00E+4nM ΔG°: >-27.9kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed