Compile Data Set for Download or QSAR
Report error Found 80 Enz. Inhib. hit(s) with all data for entry = 50038081
TargetCathepsin K(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50255753(MK-0822 | Odanacatib | CHEMBL481611)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human cathepsin KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetCathepsin K(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50233032((S)-4,4-difluoro-2-[(S)-2,2,2-trifluoro-1-(4'-meth...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetCathepsin K(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50255753(MK-0822 | Odanacatib | CHEMBL481611)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetCathepsin K(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM19489((2S)-N-(cyanomethyl)-4-methyl-2-[[(1S)-2,2,2-trifl...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetCathepsin K(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM19489((2S)-N-(cyanomethyl)-4-methyl-2-[[(1S)-2,2,2-trifl...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human cathepsin KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetCathepsin K(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50233039((S)-4-methyl-2-[(S)-2,2,2-trifluoro-1-(4'-methanes...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetCathepsin K(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50233036((2S,4S)-5,5,5-trifluoro-4-methyl-2-[(S)-2,2,2-trif...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetCathepsin K(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50233034((2S,4R)-5,5,5-trifluoro-4-methyl-2-[(S)-2,2,2-trif...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetCathepsin K(Rabbit)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM19778((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of rabbit cathepsin KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetCathepsin K(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM19778((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetCathepsin K(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM19855(N-[1-(cyanomethylcarbamoyl)cyclohexyl]-4-(4-propyl...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human cathepsin KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetCathepsin K(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50214542((S)-4-methyl-2-[(S)-2,2,2-trifluoro-1-(4'-methanes...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetCathepsin K(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50233030((S)-4-methyl-2-[(S)-2,2,2-trifluoro-1-(4'-methanes...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetCathepsin K(Rabbit)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM19489((2S)-N-(cyanomethyl)-4-methyl-2-[[(1S)-2,2,2-trifl...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of rabbit cathepsin KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetCathepsin K(Rabbit)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50255753(MK-0822 | Odanacatib | CHEMBL481611)
Affinity DataIC50: 1nMAssay Description:Inhibition of rabbit cathepsin KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetCathepsin K(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50214540((S)-4-methyl-2-[(S)-2,2,2-trifluoro-1-(4'-methanes...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetCathepsin K(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50233031((S)-n-(cyano-dicyclopropyl-methyl)-4,4,4-trifluoro...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM19778((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)
Affinity DataIC50: 2nMAssay Description:Inhibition of cathepsin L in human HepG2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetCathepsin K(Rabbit)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM19855(N-[1-(cyanomethylcarbamoyl)cyclohexyl]-4-(4-propyl...)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of rabbit cathepsin KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetCathepsin K(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50233035((S)-4-methyl-2-[(S)-2,2,2-trifluoro-1-(4'-methanes...)
Affinity DataIC50: 4nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetCathepsin K(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50233040((S)-4-methyl-2-[(S)-2,2,2-trifluoro-1-(4'-methanes...)
Affinity DataIC50: 5.10nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetCathepsin S(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM19778((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)
Affinity DataIC50: 8nMAssay Description:Inhibition of cathepsin S in human ramos cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetDipeptidyl peptidase 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50255753(MK-0822 | Odanacatib | CHEMBL481611)
Affinity DataIC50: 10nMAssay Description:Inhibition of cathepsin CMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetCathepsin Z(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50255753(MK-0822 | Odanacatib | CHEMBL481611)
Affinity DataIC50: 10nMAssay Description:Inhibition of cathepsin ZMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetPro-cathepsin H(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50255753(MK-0822 | Odanacatib | CHEMBL481611)
Affinity DataIC50: 10nMAssay Description:Inhibition of cathepsin HMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetCathepsin B(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM19778((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)
Affinity DataIC50: 14nMAssay Description:Inhibition of cathepsin B in human HepG2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetCathepsin S(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50233038((S)-4,4-dichloro-N-(cyano-dicyclopropyl-methyl)-2-...)
Affinity DataIC50: 15nMAssay Description:Inhibition of cathepsin SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetCathepsin K(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50233037((S)-4-methyl-2-[(S)-2,2,2-trifluoro-1-(4'-methanes...)
Affinity DataIC50: 16nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetCathepsin S(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50233032((S)-4,4-difluoro-2-[(S)-2,2,2-trifluoro-1-(4'-meth...)
Affinity DataIC50: 17nMAssay Description:Inhibition of cathepsin SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetCathepsin S(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50214542((S)-4-methyl-2-[(S)-2,2,2-trifluoro-1-(4'-methanes...)
Affinity DataIC50: 38nMAssay Description:Inhibition of cathepsin SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetCathepsin S(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50255753(MK-0822 | Odanacatib | CHEMBL481611)
Affinity DataIC50: 45nMAssay Description:Inhibition of cathepsin S in human ramos cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM19855(N-[1-(cyanomethylcarbamoyl)cyclohexyl]-4-(4-propyl...)
Affinity DataIC50: 48nMAssay Description:Inhibition of cathepsin L in human HepG2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetCathepsin S(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50233036((2S,4S)-5,5,5-trifluoro-4-methyl-2-[(S)-2,2,2-trif...)
Affinity DataIC50: 56nMAssay Description:Inhibition of cathepsin SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetCathepsin S(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50255753(MK-0822 | Odanacatib | CHEMBL481611)
Affinity DataIC50: 60nMAssay Description:Inhibition of cathepsin SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetCathepsin B(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM19855(N-[1-(cyanomethylcarbamoyl)cyclohexyl]-4-(4-propyl...)
Affinity DataIC50: 61nMAssay Description:Inhibition of cathepsin B in human HepG2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50214542((S)-4-methyl-2-[(S)-2,2,2-trifluoro-1-(4'-methanes...)
Affinity DataIC50: 67nMAssay Description:Inhibition of cathepsin LMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetCathepsin S(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50233031((S)-n-(cyano-dicyclopropyl-methyl)-4,4,4-trifluoro...)
Affinity DataIC50: 89nMAssay Description:Inhibition of cathepsin SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetCathepsin S(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM19489((2S)-N-(cyanomethyl)-4-methyl-2-[[(1S)-2,2,2-trifl...)
Affinity DataIC50: 95nMAssay Description:Inhibition of cathepsin S in human ramos cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetCathepsin B(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50233032((S)-4,4-difluoro-2-[(S)-2,2,2-trifluoro-1-(4'-meth...)
Affinity DataIC50: 100nMAssay Description:Inhibition of cathepsin BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50233038((S)-4,4-dichloro-N-(cyano-dicyclopropyl-methyl)-2-...)
Affinity DataIC50: 110nMAssay Description:Inhibition of cathepsin LMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetCathepsin S(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50233034((2S,4R)-5,5,5-trifluoro-4-methyl-2-[(S)-2,2,2-trif...)
Affinity DataIC50: 170nMAssay Description:Inhibition of cathepsin SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetCathepsin S(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM19489((2S)-N-(cyanomethyl)-4-methyl-2-[[(1S)-2,2,2-trifl...)
Affinity DataIC50: 178nMAssay Description:Inhibition of cathepsin SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetCathepsin S(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50233030((S)-4-methyl-2-[(S)-2,2,2-trifluoro-1-(4'-methanes...)
Affinity DataIC50: 217nMAssay Description:Inhibition of cathepsin SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50233036((2S,4S)-5,5,5-trifluoro-4-methyl-2-[(S)-2,2,2-trif...)
Affinity DataIC50: 262nMAssay Description:Inhibition of cathepsin LMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM19489((2S)-N-(cyanomethyl)-4-methyl-2-[[(1S)-2,2,2-trifl...)
Affinity DataIC50: 264nMAssay Description:Inhibition of cathepsin LMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetCathepsin S(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50233039((S)-4-methyl-2-[(S)-2,2,2-trifluoro-1-(4'-methanes...)
Affinity DataIC50: 266nMAssay Description:Inhibition of cathepsin SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetCathepsin B(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50233031((S)-n-(cyano-dicyclopropyl-methyl)-4,4,4-trifluoro...)
Affinity DataIC50: 434nMAssay Description:Inhibition of cathepsin BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50233039((S)-4-methyl-2-[(S)-2,2,2-trifluoro-1-(4'-methanes...)
Affinity DataIC50: 456nMAssay Description:Inhibition of cathepsin LMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50233032((S)-4,4-difluoro-2-[(S)-2,2,2-trifluoro-1-(4'-meth...)
Affinity DataIC50: 472nMAssay Description:Inhibition of cathepsin LMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50233030((S)-4-methyl-2-[(S)-2,2,2-trifluoro-1-(4'-methanes...)
Affinity DataIC50: 667nMAssay Description:Inhibition of cathepsin LMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
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